Výsledky vyhledávání - "Judith Baumeister"

Akademický článek

Pre-Clinical Intravenous Serum Pharmacokinetics of Albumin Binding and Non-Half-Life Extended Nanobodies®

Autor: Sven Hoefman, Ingrid Ottevaere, Judith Baumeister, Maria Laura Sargentini-Maier

Publikováno v: Antibodies, Vol 4, Iss 3, Pp 141-156 (2015)

Nanobodies are antigen-binding, single variable domain proteins derived from naturally-occurring, heavy chain only antibodies. They are highly soluble, stable, and can be linked to build multi-specific formats. Several Nanobodies are currently in cli

Externí odkaz: https://doaj.org/article/7f0967633ca64b7baa626d48f6ecc982

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Repeated-Dose Toxicity, Biodistribution, and Shedding Assessments With a ChAd155 Respiratory Syncytial Virus Vaccine Candidate Evaluated in Rabbits and Rats

Autor: Alan H. Stokes, Camille Planty, Johanne Pion, Philippe Ancian, Alexandra Rogue, Carine Bansard, Jérémy Silvano, Dominique Papineau, Nawel Ben Abdeljelil, Giulietta Maruggi, Haifeng Song, Catherine Spickler, Karine Blouin, Guillaume Dubois, Luis-Alexander Rodriguez, Judith Baumeister, Ann-Muriel Steff, Eric Destexhe

Publikováno v: INTERNATIONAL JOURNAL OF TOXICOLOGY, 41, 263-275

Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections (LRTI) in infants, and toddlers and vaccines are not yet available. A pediatric RSV vaccine (ChAd155-RSV) is being developed to protect infants against R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d41451c502ad2fec400cba9956b9ee
http://hdl.handle.net/20.500.12470/2779

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Repeated Dose Toxicity Study and Developmental and Reproductive Toxicology Studies of a Respiratory Syncytial Virus Candidate Vaccine in Rabbits and Rats

Autor: Ornella Binazon, Marie-Noëlle Donner, Alan H. Stokes, Vimala Vemireddi, Luis-Alexander Rodriguez, Daniel E Fisher, Lorraine M. Posobiec, Jeffrey H. Charlap, Mary K. Ziejewski, Niraj Tripathi, Ritankar Majumdar, Payal Khanna Weiss, Judith Baumeister, Kelle Franklin, Badiaa Bouzya, Michael Alan Ringenberg

Publikováno v: International journal of toxicology. 40(2)

Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections, and vaccines are needed to treat young children and older adults. One of GSK’s candidate vaccines for RSV contains recombinant RSVPreF3 protein mainta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8028a8759cd0d0e4c2dbe99fc2241c0
https://pubmed.ncbi.nlm.nih.gov/33517807

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Chimeric hemagglutinin supra-seasonal universal influenza vaccine candidates administered sequentially by the intramuscular route are locally and systemically well-tolerated in rabbits

Autor: Catherine Thirion-Delalande, Corey P. Mallett, Badiaa Bouzya, Ronan N. Rouxel, Eric Destexhe, Emilie Grosdidier, Adèle Bouhraoua, Judith Baumeister

Publikováno v: Regulatory Toxicology and Pharmacology. 113:104625

Sequential intramuscular immunization with chimeric hemagglutinins (cHA) composed of the same conserved HA stalk domain and distinct HA heads is a proposed strategy to produce a supra-seasonal universal influenza vaccine. To evaluate the local tolera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d7c69819fd8fdca29997cb531c1731
https://doi.org/10.1016/j.yrtph.2020.104625

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In Vitro and In Vivo Activities of the Novel Anticytomegalovirus Compound AIC246

Autor: Holger Zimmermann, Thomas Goldner, Daniela Paulsen, Tobias Wunberg, Judith Baumeister, Peter Lischka, Guy Hewlett, Helga Ruebsamen-Schaeff

Publikováno v: Antimicrobial Agents and Chemotherapy. 54:1290-1297

Human cytomegalovirus (HCMV) remains a serious threat for immunocompromised individuals, including transplant recipients and newborns. To date, all drugs licensed for the treatment of HCMV infection and disease target the viral DNA polymerase. Althou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0152783584c1c80055bade5015fcd36
https://doi.org/10.1128/aac.01596-09

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Superior Efficacy of Helicase-Primase Inhibitor BAY 57–1293 for Herpes Infection and Latency in the Guinea Pig Model of Human Genital Herpes Disease

Autor: Judith Baumeister, Peter Eckenberg, Kerstin Henninger, Ruediger Fischer, Helga Ruebsamen-Waigmann, Gerald Kleymann

Publikováno v: Antiviral Chemistry and Chemotherapy. 18:35-48

The efficacy of BAY 57–1293, a novel non-nucleosidic inhibitor of herpes simplex virus 1 and 2 (HSV-1 and HSV-2), bovine herpesvirus and pseudorabies virus, was studied in the guinea pig model of genital herpes in comparison with the licensed drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385d126ee7e7bee8a23f3792602c40c7
https://doi.org/10.1177/095632020701800104

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The preclinical pharmacology of the high affinity anti-IL-6R Nanobody (R) ALX-0061 supports its clinical development in rheumatoid arthritis

Autor: Judith Baumeister, Sandy Jacobs, Cedric Jozef Neotere Ververken, Joost Alexander Kolkman, Bert A. 't Hart, Hans Ulrichts, Michel P.M. Vierboom, Sofie Poelmans, Elia Breedveld, Maarten Van Roy, Sven Hoefman, Els Beirnaert, Lieselot Bontinck, Alex Hemeryck

Publikováno v: Arthritis Research and Therapy, 17:135. BioMed Central Ltd.
Arthritis Research & Therapy

Introduction The pleiotropic cytokine interleukin-6 (IL-6) plays an important role in the pathogenesis of different diseases, including rheumatoid arthritis (RA). ALX-0061 is a bispecific Nanobody® with a high affinity and potency for IL-6 receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f3ced2bf086f329611dd16a039053c
https://doi.org/10.1186/s13075-015-0651-0

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New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease

Publikováno v: Nature Medicine. 8:392-398

The vast majority of the world population is infected with at least one member of the human herpesvirus family. Herpes simplex virus (HSV) infections are the cause of cold sores and genital herpes as well as life-threatening or sight-impairing diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9178826b59e6a74c1a82bf9a9f9e4b22
https://doi.org/10.1038/nm0402-392

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Pseudorabies virus glycoprotein gK is a virion structural component involved in virus release but is not required for entry

Autor: Barbara G. Klupp, Harald Granzow, Judith Baumeister, Thomas C. Mettenleiter, Petra Dietz

Publikováno v: Journal of virology. 72(3)

The pseudorabies virus (PrV) gene homologous to herpes simplex virus type 1 (HSV-1) UL53, which encodes HSV-1 glycoprotein K (gK), has recently been sequenced (J. Baumeister, B. G. Klupp, and T. C. Mettenleiter, J. Virol. 69:5560–5567, 1995). To id

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5290b5a1f3cc580441066f770f0c6f
https://pubmed.ncbi.nlm.nih.gov/9499048

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