Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Judith Altarejos"'
Autor:
Parsa Akbari, Olukayode A. Sosina, Jonas Bovijn, Karl Landheer, Jonas B. Nielsen, Minhee Kim, Senem Aykul, Tanima De, Mary E. Haas, George Hindy, Nan Lin, Ian R. Dinsmore, Jonathan Z. Luo, Stefanie Hectors, Benjamin Geraghty, Mary Germino, Lampros Panagis, Prodromos Parasoglou, Johnathon R. Walls, Gabor Halasz, Gurinder S. Atwal, Regeneron Genetics Center, DiscovEHR Collaboration, Marcus Jones, Michelle G. LeBlanc, Christopher D. Still, David J. Carey, Alice Giontella, Marju Orho-Melander, Jaime Berumen, Pablo Kuri-Morales, Jesus Alegre-Díaz, Jason M. Torres, Jonathan R. Emberson, Rory Collins, Daniel J. Rader, Brian Zambrowicz, Andrew J. Murphy, Suganthi Balasubramanian, John D. Overton, Jeffrey G. Reid, Alan R. Shuldiner, Michael Cantor, Goncalo R. Abecasis, Manuel A. R. Ferreira, Mark W. Sleeman, Viktoria Gusarova, Judith Altarejos, Charles Harris, Aris N. Economides, Vincent Idone, Katia Karalis, Giusy Della Gatta, Tooraj Mirshahi, George D. Yancopoulos, Olle Melander, Jonathan Marchini, Roberto Tapia-Conyer, Adam E. Locke, Aris Baras, Niek Verweij, Luca A. Lotta
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Fat distribution is associated with cardiometabolic disease, although it has been less well studied than overall obesity. In a multiancestry exome-sequencing study, the authors identified predicted loss-of-function mutations in INHBE associated with
Externí odkaz:
https://doaj.org/article/9f24eb7300be4033aaf87fbf13407526
Autor:
Charleen Hunt, Suzanne A. Hartford, Derek White, Evangelos Pefanis, Timothy Hanna, Clarissa Herman, Jarrell Wiley, Heather Brown, Qi Su, Yurong Xin, Dennis Voronin, Hien Nguyen, Judith Altarejos, Keith Crosby, Jeffery Haines, Sarah Cancelarich, Meghan Drummond, Sven Moller-Tank, Ryan Malpass, Jacqueline Buckley, Maria del Pilar Molina-Portela, Gustavo Droguett, David Frendewey, Eric Chiao, Brian Zambrowicz, Guochun Gong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
CRISPR-Cas9 is a gene editing tool that can be used to modulate gene expression. Here, the authors report the generation of a mouse model that express all components of the CRISPR-Cas9 guide directed Synergistic Activation Mediator (SAM), demonstrate
Externí odkaz:
https://doaj.org/article/17fb14b41cbb4fa7890fbff2faf8ff19
Autor:
Marisa Carbonaro, Kehui Wang, Hui Huang, Davor Frleta, Aditi Patel, Alexander Pennington, Mathieu Desclaux, Sven Moller-Tank, Justin Grindley, Judith Altarejos, Jun Zhong, Greg Polites, William Poueymirou, Stephen Jaspers, Christos Kyratsous, Brian Zambrowicz, Andrew Murphy, John C. Lin, Lynn E. Macdonald, Christopher Daly, Mark Sleeman, Gavin Thurston, Zhe Li
Publikováno v:
Science Advances. 9
Liver steatosis is an increasing health issue with few therapeutic options, partly because of a paucity of experimental models. In humanized liver rodent models, abnormal lipid accumulation in transplanted human hepatocytes occurs spontaneously. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::944cb1b84f4b1e58d4f3d83c7e56e4a6
https://doi.org/10.1126/sciadv.adf4490
https://doi.org/10.1126/sciadv.adf4490
Autor:
Jack A. Kosmicki, Charles Paulding, Nan Lin, Andrew J. Murphy, Jerome I. Rotter, Brian Zambrowicz, Niek Verweij, Luca A. Lotta, Michal L. Schwartzman, Giusy Della Gatta, Yii-Der Ida Chen, Alexander H. Li, Suganthi Balasubramanian, Jason M. Torres, Hyun Min Kang, Rory Collins, Parsa Akbari, Michael E. Dunn, Gonçalo R. Abecasis, Christian Benner, David J. Carey, Svati H. Shah, Jonathan Marchini, Giovanni Coppola, Marcus B. Jones, Olle Melander, Christopher D. Still, Yi-Ya Fang, Olukayode A. Sosina, Manuel A. R. Ferreira, Roberto Tapia-Conyer, Michael Cantor, Aris N. Economides, Dylan Sun, Adam E. Locke, Jonathan V. Pascale, Daniel J. Rader, Ankit Gilani, Joelle Mbatchou, Jesus Alegre-Díaz, Mark W. Sleeman, Trikaldarshi Persaud, Jeffrey G. Reid, Pablo Kuri-Morales, Jaime Berumen-Campos, John D. Overton, Aris Baras, Ercument Dirice, Sakib Hossain, Alicia Hawes, George D. Yancopoulos, Jonathan Emberson, Victor Garcia, Judith Altarejos, Lori Khrimian, Katia Karalis, William E. Kraus, Tooraj Mirshahi, Kevin Agostinucci, Alan R. Shuldiner
Publikováno v:
Science
Introduction Obesity accounts for a substantial and growing burden of disease globally. Body adiposity is highly heritable, and human genetic studies can lead to biological and therapeutic insights. Rationale Whole-exome sequencing of hundreds of tho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df724bff85dd4d7320fb650eae3fa2a5
https://doi.org/10.1126/science.abf8683
https://doi.org/10.1126/science.abf8683
Autor:
Jeffery Haines, Derek White, Maria del Pilar Molina-Portela, Brian Zambrowicz, Gustavo Droguett, Jarrell Wiley, Clarissa Herman, Timothy Hanna, Judith Altarejos, Hien Nguyen, Sven Moller-Tank, Qi Su, Heather Brown, Sarah Cancelarich, Dennis Voronin, Jacqueline Buckley, Evangelos Pefanis, Eric Chiao, Suzanne Hartford, David Frendewey, Meghan Drummond, Ryan Malpass, Keith Crosby, Charleen Hunt, Yurong Xin, Guochun Gong
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
CRISPR-based transcriptional activation is a powerful tool for functional gene interrogation; however, delivery difficulties have limited its applications in vivo. Here, we created a mouse model expressing all components of the CRISPR-Cas9 guide RNA-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39debf08c4dc1f37634a7861458d9e2d
https://doi.org/10.1038/s41467-021-22932-4
https://doi.org/10.1038/s41467-021-22932-4
Autor:
David J. Carey, Aris Baras, H. Lester Kirchner, Wenzhen Ge, Ryan Colonie, Jesper Gromada, Jeffrey Staples, Ashish Yadav, Joseph B. Leader, Alan R. Shuldiner, Claudia Gonzaga-Jauregui, Judith Altarejos, Michael F. Murray, Jeffrey G. Reid, Cristopher V. Van Hout, John D. Overton, Omri Gottesman, Steve Gao
Publikováno v:
Diabetes. 69(2)
Lipodystrophies are a group of disorders characterized by absence or loss of adipose tissue and abnormal fat distribution, commonly accompanied by metabolic dysregulation. Although considered rare disorders, their prevalence in the general population
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c0da0c34e57db1b53b49b500d14a504
https://pubmed.ncbi.nlm.nih.gov/31836692
https://pubmed.ncbi.nlm.nih.gov/31836692
Autor:
Youngsup Song, Judith Altarejos, Mark O. Goodarzi, Hiroshi Inoue, Xiuqing Guo, Rebecca Berdeaux, Jeong-Ho Kim, Jason Goode, Motoyuki Igata, Jose C. Paz, Meghan F. Hogan, Pankaj K. Singh, Naomi Goebel, Lili Vera, Nina Miller, Jinrui Cui, Michelle R. Jones, CHARGE Consortium, GIANT Consortium, Yii-Der I. Chen, Kent D. Taylor, Willa A. Hsueh, Jerome I. Rotter, Marc Montminy
Publikováno v:
Nature. 468:933-939
The adipose-derived hormone leptin maintains energy balance in part through central nervous system-mediated increases in sympathetic outflow that enhance fat burning. Triggering of β-adrenergic receptors in adipocytes stimulates energy expenditure b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63ce6fecd72c26709a23d913222b1d52
https://doi.org/10.1038/nature09564
https://doi.org/10.1038/nature09564