Výsledky vyhledávání - "Judith A. Varner"

Akademický článek

PI3Kγ inhibition combined with DNA vaccination unleashes a B-cell-dependent antitumor immunity that hampers pancreatic cancer

Autor: Claudia Curcio, Gianluca Mucciolo, Cecilia Roux, Silvia Brugiapaglia, Alessandro Scagliotti, Giorgia Guadagnin, Laura Conti, Dario Longo, Demis Grosso, Mauro Giulio Papotti, Emilio Hirsch, Paola Cappello, Judith A. Varner, Francesco Novelli

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-13 (2024)

Abstract Phosphoinositide-3-kinase γ (PI3Kγ) plays a critical role in pancreatic ductal adenocarcinoma (PDA) by driving the recruitment of myeloid-derived suppressor cells (MDSC) into tumor tissues, leading to tumor growth and metastasis. MDSC also

Externí odkaz: https://doaj.org/article/bb1468ffdb6c4868987a0ce661e0f623

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Akademický článek

PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation

Autor: Michael C. Schmid, Sang Won Kang, Hui Chen, Marc Paradise, Anghesom Ghebremedhin, Megan M. Kaneda, Shao-Ming Chin, Anh Do, D. Martin Watterson, Judith A. Varner

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Myeloid cell recruitment during tumor inflammation depends on the VCAM-1 receptor integrin α4β1. Here the authors show that a high molecular weight form of myosin light chain kinase, MLCK210, is required for myeloid cell integrin α4β1 activation

Externí odkaz: https://doaj.org/article/b6c618803fc74a3887178594aab67db6

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Akademický článek

Integrin CD11b activation drives anti-tumor innate immunity

Autor: Michael C. Schmid, Samia Q. Khan, Megan M. Kaneda, Paulina Pathria, Ryan Shepard, Tiani L. Louis, Sudarshan Anand, Gyunghwi Woo, Chris Leem, M. Hafeez Faridi, Terese Geraghty, Anugraha Rajagopalan, Seema Gupta, Mansoor Ahmed, Roberto I. Vazquez-Padron, David A. Cheresh, Vineet Gupta, Judith A. Varner

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Recruitment of myeloid cells can be regulated by integrin CD11b. Here the authors show that in the tumor microenvironment, CD11b is not essential for recruitment of myeloid cells but rather induces macrophage anti-tumorigenic polarization via stimula

Externí odkaz: https://doaj.org/article/fa609fba06764331883a98cafef892a0

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