Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Judith A. Varner"'
Autor:
Claudia Curcio, Gianluca Mucciolo, Cecilia Roux, Silvia Brugiapaglia, Alessandro Scagliotti, Giorgia Guadagnin, Laura Conti, Dario Longo, Demis Grosso, Mauro Giulio Papotti, Emilio Hirsch, Paola Cappello, Judith A. Varner, Francesco Novelli
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-13 (2024)
Abstract Phosphoinositide-3-kinase γ (PI3Kγ) plays a critical role in pancreatic ductal adenocarcinoma (PDA) by driving the recruitment of myeloid-derived suppressor cells (MDSC) into tumor tissues, leading to tumor growth and metastasis. MDSC also
Externí odkaz:
https://doaj.org/article/bb1468ffdb6c4868987a0ce661e0f623
Autor:
Michael C. Schmid, Sang Won Kang, Hui Chen, Marc Paradise, Anghesom Ghebremedhin, Megan M. Kaneda, Shao-Ming Chin, Anh Do, D. Martin Watterson, Judith A. Varner
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Myeloid cell recruitment during tumor inflammation depends on the VCAM-1 receptor integrin α4β1. Here the authors show that a high molecular weight form of myosin light chain kinase, MLCK210, is required for myeloid cell integrin α4β1 activation
Externí odkaz:
https://doaj.org/article/b6c618803fc74a3887178594aab67db6
Autor:
Michael C. Schmid, Samia Q. Khan, Megan M. Kaneda, Paulina Pathria, Ryan Shepard, Tiani L. Louis, Sudarshan Anand, Gyunghwi Woo, Chris Leem, M. Hafeez Faridi, Terese Geraghty, Anugraha Rajagopalan, Seema Gupta, Mansoor Ahmed, Roberto I. Vazquez-Padron, David A. Cheresh, Vineet Gupta, Judith A. Varner
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Recruitment of myeloid cells can be regulated by integrin CD11b. Here the authors show that in the tumor microenvironment, CD11b is not essential for recruitment of myeloid cells but rather induces macrophage anti-tumorigenic polarization via stimula
Externí odkaz:
https://doaj.org/article/fa609fba06764331883a98cafef892a0
Autor:
Judith A. Varner, Emilio Hirsch, Francesco Novelli, Roman Sasik, Mark A. Valasek, Andrew M. Lowy, Michael Bouvet, Evangeline Mose, Ping Sun, Michael C. Schmid, Philippe Foubert, Chanae R. Hardamon, Natacha Ralainirina, Abraham V. Nguyen, Paola Cappello, Megan M. Kaneda
Immune checkpoint characterization of PDAC tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d42df2b54edf2580411cad7d160071d
https://doi.org/10.1158/2159-8290.22531068.v1
https://doi.org/10.1158/2159-8290.22531068.v1
Autor:
Judith A. Varner, Emilio Hirsch, Francesco Novelli, Roman Sasik, Mark A. Valasek, Andrew M. Lowy, Michael Bouvet, Evangeline Mose, Ping Sun, Michael C. Schmid, Philippe Foubert, Chanae R. Hardamon, Natacha Ralainirina, Abraham V. Nguyen, Paola Cappello, Megan M. Kaneda
Effect of PI3Kγ inhibitors on PDAC growth and survival.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a06bad5e52ea69b31a2f869169b76a
https://doi.org/10.1158/2159-8290.22531074
https://doi.org/10.1158/2159-8290.22531074
Autor:
Lisa M. Coussens, Judith A. Varner, Betty Y. Chang, Bryan Irving, Brett Sheppard, Margaret A. Tempero, Douglas Hanahan, Grace Kim, Peter Olson, Morgan Truitt, Shannon M. Liudahl, Sara Gorjestani, Brian Ruffell, Nesrine I. Affara, Abraham V. Nguyen, Takahiro Tsujikawa, Megan M. Kaneda, Andrew J. Gunderson
Supplementary Methods and Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d345d677af53ec94a76c7929e9ef7a6
https://doi.org/10.1158/2159-8290.22530962.v1
https://doi.org/10.1158/2159-8290.22530962.v1
Autor:
Judith A. Varner, Emilio Hirsch, Francesco Novelli, Roman Sasik, Mark A. Valasek, Andrew M. Lowy, Michael Bouvet, Evangeline Mose, Ping Sun, Michael C. Schmid, Philippe Foubert, Chanae R. Hardamon, Natacha Ralainirina, Abraham V. Nguyen, Paola Cappello, Megan M. Kaneda
Effect of PI3Kγ inhibition on immune cell populations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1198a0fddfa790cf000189079d3f61de
https://doi.org/10.1158/2159-8290.22531080
https://doi.org/10.1158/2159-8290.22531080
Autor:
Judith A. Varner, Emilio Hirsch, Francesco Novelli, Roman Sasik, Mark A. Valasek, Andrew M. Lowy, Michael Bouvet, Evangeline Mose, Ping Sun, Michael C. Schmid, Philippe Foubert, Chanae R. Hardamon, Natacha Ralainirina, Abraham V. Nguyen, Paola Cappello, Megan M. Kaneda
Intravital imaging of orthotopic PDAC growth and spread.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9e4d6c6756832525fb6396c37f339dc
https://doi.org/10.1158/2159-8290.22531077
https://doi.org/10.1158/2159-8290.22531077
Immunosuppressive myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) accumulate in tumors where they inhibit T cell–mediated antitumor immune responses and promote tumor progression. Myeloid cell PI3Kγ plays a role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47cb4795fccd44e1ec9372cd8c992ed7
https://doi.org/10.1158/2326-6066.c.6548029.v1
https://doi.org/10.1158/2326-6066.c.6548029.v1