Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Judith A. Kapp"'
Publikováno v:
Cell Transplantation, Vol 11 (2002)
Our goal is to develop effective islet xenografts for treating human diabetes. We have studied microencapsulated neonatal porcine islet cell clusters (ICCs) transplanted intraperitoneally in spontaneously diabetic NOD mice, where they function to mai
Externí odkaz:
https://doaj.org/article/6256905fedb8417ea3850ec06d682e7a
Autor:
Collin J. Weber M.D., D.M.Sci, Mary K. Hagler, John T. Chryssochoos, Judith A. Kapp, Gregory S. Korbutt, Ray V. Rajotte, Peter S. Linsley
Publikováno v:
Cell Transplantation, Vol 6 (1997)
Externí odkaz:
https://doaj.org/article/69f5b67b7188472db7fb55f8f2ecac09
Autor:
Judith A. Kapp, R. Pat Bucy
Publikováno v:
Human Immunology. 69:715-720
This review focuses on the role of antigen-specific T cells that mediate active inhibition of immune responses over the past 35 years since their initial description. The field has experienced several changes in the accepted paradigm of such suppress
Publikováno v:
Journal of Neuroimmunology. 164:66-75
In this report, we provide evidence that muscarinic receptors play a role in the generation of CD8 + cytolytic T lymphocytes. Analysis of mice with targeted deletions of each of the known muscarinic receptors (M 1 –M 5 ) showed that CD8 + T cells f
Autor:
Susan A. Safley, Carol Tucker-Burden, Judith A. Kapp, Linda M. Kapp, Collin J. Weber, Bernhard J. Hering
Publikováno v:
Transplantation. 79:409-418
Background Transplantation of human islets has been successful clinically. Since human islets are scarce, we are studying microencapsulated porcine islet xenografts in nonobese diabetic (NOD) mice. We have evaluated the cellular immune response in NO
Publikováno v:
Ocular Immunology and Inflammation. 13:149-157
Purpose: We tested whether antigen administration via the anterior chamber (a.c.) was equivalent to intravenous (i.v.) or mucosal administration of antigen. Methods: Ovalbumin (OVA)-specific CD8+ T cells (OT-I) were enumerated in lymphoid tissues of
Publikováno v:
American Journal of Transplantation. 4:1762-1768
Understanding the mechanisms of rejection of organs transplanted between unrelated individuals is confounded by the complexity of the alloantigens and the diversity of T cells responding to these alloantigens. To circumvent these problems, we develop
Publikováno v:
Cellular Immunology. 230:44-55
T cells from TCR transgenic mice, expressing receptors specific for an allogeneic MHC class I peptide, were used to track T cell activation and migration in normal adoptive recipients that were subsequently transplanted with heterotopic hearts that w
Publikováno v:
Immunology. 111:155-164
Oral administration of antigen induces a state of tolerance that is associated with activation of CD8+ T cells that can transfer unresponsiveness to naïve syngeneic hosts. These T cells are not lytic, but they inhibit development of antibody, CD4+ T