Výsledky vyhledávání - "Judith A. Elias"

Supplementary Figure 4 from Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia

Autor: Eric Eldering, Marinus H.J. van Oers, Tim Beaumont, Arnon P. Kater, Dieuwertje M. Luijks, Jacoline van Laar, Judith A. Elias, Esther C.W. Breij, Christian R. Geest, Jacqueline M. Tromp

PDF file - 732K, A. CLL cells were stimulated with CD40L for 72 hrs. After detachment, cells were incubated with 0.1 �M of ABT-737. Protein lysates were probed for Mcl-1, Bfl-1, Noxa and �-actin. B. Densitometric analysis of Mcl-1/ �-actin leve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77e2fa7bd328fc37344c0fd46b8fa443
https://doi.org/10.1158/1078-0432.22444197

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Data from Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia

Autor: Eric Eldering, Marinus H.J. van Oers, Tim Beaumont, Arnon P. Kater, Dieuwertje M. Luijks, Jacoline van Laar, Judith A. Elias, Esther C.W. Breij, Christian R. Geest, Jacqueline M. Tromp

Purpose: Chronic lymphocytic leukemia (CLL) cells in lymph nodes (LN), from which relapses are postulated to originate, display an antiapoptotic profile in contrast to CLL cells from peripheral blood (PB). The BH3 mimetic ABT-737 antagonizes the anti

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https://doi.org/10.1158/1078-0432.c.6520092

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Supplementary Figure 5 from Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia

Autor: Eric Eldering, Marinus H.J. van Oers, Tim Beaumont, Arnon P. Kater, Dieuwertje M. Luijks, Jacoline van Laar, Judith A. Elias, Esther C.W. Breij, Christian R. Geest, Jacqueline M. Tromp

PDF file - 866K, CLL cells were stimulated with CD40L for 48 hrs. After detachment, cells were incubated with 10 �M or 100 �M fludarabine � Q-VD (12,5 �M), � NAC (5mM). Protein lysates were probed for Noxa, Mcl-1 and �-actin.

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https://doi.org/10.1158/1078-0432.22444194.v1

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Supplementary Figure 1 from Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia

Autor: Eric Eldering, Marinus H.J. van Oers, Tim Beaumont, Arnon P. Kater, Dieuwertje M. Luijks, Jacoline van Laar, Judith A. Elias, Esther C.W. Breij, Christian R. Geest, Jacqueline M. Tromp

PDF file - 986K, A. ABT-737 resistant CLL cells were stimulated with CD40L for 72 hours (n=4). The black line shows apoptosis levels from CLL cells detached from the feeder layer and subsequently treated with different concentrations of ABT-737 (0.00

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https://doi.org/10.1158/1078-0432.22444206

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Supplementary Figure 2 from Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia

Autor: Eric Eldering, Marinus H.J. van Oers, Tim Beaumont, Arnon P. Kater, Dieuwertje M. Luijks, Jacoline van Laar, Judith A. Elias, Esther C.W. Breij, Christian R. Geest, Jacqueline M. Tromp

PDF file - 620K, CLL cells were stimulated with CD40L for the indicated time (24, 48 and 72 hrs). Western blots of Bfl-1 were quantified with Odyssey software in both ABT-737 sensitive (n=4) and ABT-737 resistant (n=4) CD40-stimulated CLL cells. Bars

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5eb35417fc9c7b9022dcebd19a5987
https://doi.org/10.1158/1078-0432.22444203.v1

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Supplementary Figure 3 from Tipping the Noxa/Mcl-1 Balance Overcomes ABT-737 Resistance in Chronic Lymphocytic Leukemia

Autor: Eric Eldering, Marinus H.J. van Oers, Tim Beaumont, Arnon P. Kater, Dieuwertje M. Luijks, Jacoline van Laar, Judith A. Elias, Esther C.W. Breij, Christian R. Geest, Jacqueline M. Tromp

PDF file - 793K, Nucleofection with Noxa siRNA or control siRNA was performed on CLL cells in the presence or absence of the proteasoom inhibitor GSI. Protein lysates were probed for Mcl-1, Noxa and �-actin. As a control, lysates of untransfected C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::490a5dc6e16ab554cc08efba89221045
https://doi.org/10.1158/1078-0432.22444200.v1

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Akademický článek

The small GTPase RhoB regulates TNFα signaling in endothelial cells.

Autor: Jeffrey Kroon, Simon Tol, Sven van Amstel, Judith A Elias, Mar Fernandez-Borja

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e75031 (2013)

The inflammatory response of endothelial cells triggered by cytokines such as TNFα and IL1β plays a pivotal role in innate immunity. Upon pro-inflammatory cytokine stimulation, endothelial cells produce chemokines and cytokines that attract and act

Externí odkaz: https://doaj.org/article/0a4b0bdddf6f4a459b3d51ceb8b0557c