Zobrazeno 1 - 10
of 280
pro vyhledávání: '"Judith A Shizuru"'
Autor:
Surbhi Sidana, Andriyana K. Bankova, Hitomi Hosoya, Shaji K. Kumar, Tyson H. Holmes, John Tamaresis, Anne Le, Lori S. Muffly, Sofia Maysel-Auslender, Laura Johnston, Sally Arai, Robert Lowsky, Everett Meyer, Andrew Rezvani, Wen-Kai Weng, Matthew J. Frank, Parveen Shiraz, Holden T. Maecker, Ying Lu, David B. Miklos, Judith A. Shizuru
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract MGTA-145 or GROβT, a CXCR2 agonist, has shown promising activity for hematopoietic stem cell (HSC) mobilization with plerixafor in pre-clinical studies and healthy volunteers. Twenty-five patients with multiple myeloma enrolled in a phase 2
Externí odkaz:
https://doaj.org/article/c4ea76784f8e439895fbf960f62bde47
Autor:
Chiara F. Magnani, Renier Myburgh, Silvan Brunn, Morgane Chambovey, Marianna Ponzo, Laura Volta, Francesco Manfredi, Christian Pellegrino, Steve Pascolo, Csaba Miskey, Zoltán Ivics, Judith A. Shizuru, Dario Neri, Markus G. Manz
Publikováno v:
Molecular Therapy: Oncolytics, Vol 30, Iss , Pp 56-71 (2023)
Discrimination between hematopoietic stem cells and leukemic stem cells remains a major challenge for acute myeloid leukemia immunotherapy. CAR T cells specific for the CD117 antigen can deplete malignant and healthy hematopoietic stem cells before c
Externí odkaz:
https://doaj.org/article/fb577a1a841d43ec95f8517deb5c459e
Autor:
Michael A. Spinner, Vanessa E. Kennedy, John S. Tamaresis, Philip W. Lavori, Sally Arai, Laura J. Johnston, Everett H. Meyer, David B. Miklos, Lori S. Muffly, Robert S. Negrin, Andrew R. Rezvani, Judith A. Shizuru, Wen-Kai Weng, Richard T. Hoppe, Samuel Strober, Robert Lowsky
Publikováno v:
Blood Advances, Vol 3, Iss 16, Pp 2454-2464 (2019)
Abstract: Nonmyeloablative total lymphoid irradiation and antithymocyte globulin (TLI-ATG) conditioning is protective against graft-versus-host disease (GVHD), while retaining graft-versus-tumor activity across various hematologic malignancies. We re
Externí odkaz:
https://doaj.org/article/43899d6eaf0e47758cc194b59604146d
Autor:
Agnieszka Czechowicz, Rahul Palchaudhuri, Amelia Scheck, Yu Hu, Jonathan Hoggatt, Borja Saez, Wendy W. Pang, Michael K. Mansour, Tiffany A. Tate, Yan Yi Chan, Emily Walck, Gerlinde Wernig, Judith A. Shizuru, Florian Winau, David T. Scadden, Derrick J. Rossi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Hematopoietic stem cell (HSC) transplantation is a desirable treatment for many non-malignant and malignant diseases, but its use requires preconditioning of recipients with irradiation or chemotherapy that often induces high toxicity. Here the autho
Externí odkaz:
https://doaj.org/article/9ffac621975f4bccb6eaeafd10b5ba55
Autor:
Michael A. Spinner, Marcelo Fernández-Viña, Lisa E. Creary, Olivia Quinn, Linda Elder, Sally Arai, Laura J. Johnston, Everett H. Meyer, David B. Miklos, Lori S. Muffly, Robert S. Negrin, Judith A. Shizuru, Wen-Kai Weng, Ginna G. Laport, Samuel Strober, Robert Lowsky, Andrew R. Rezvani
Publikováno v:
Blood Advances, Vol 1, Iss 17, Pp 1347-1357 (2017)
Abstract: Many patients lack a fully HLA-matched donor for hematopoietic cell transplantation (HCT), and HLA mismatch is typically associated with inferior outcomes. Total lymphoid irradiation and antithymocyte globulin (TLI-ATG) is a nonmyeloablativ
Externí odkaz:
https://doaj.org/article/67a43573dd224658960f49adfc9ca942
Autor:
Antonio Pierini, Hidekazu Nishikii, Jeanette Baker, Takaharu Kimura, Hye-Sook Kwon, Yuqiong Pan, Yan Chen, Maite Alvarez, William Strober, Andrea Velardi, Judith A. Shizuru, Joy Y. Wu, Shigeru Chiba, Robert S. Negrin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Treg cells suppress peripheral immune responses, but their function in haematopoiesis is unclear. Here the authors show they modulate the bone marrow microenvironment to sustain haematopoietic stem cell-driven generation of mature B cells.
Externí odkaz:
https://doaj.org/article/d29f840a46334d1d870fa58393c51f4b
Autor:
Enrico Maffini, Barry E. Storer, Brenda M. Sandmaier, Benedetto Bruno, Firoozeh Sahebi, Judith A. Shizuru, Thomas R. Chauncey, Parameswaran Hari, Thoralf Lange, Michael A. Pulsipher, Peter A. McSweeney, Leona Holmberg, Pamela S. Becker, Damian J. Green, Marco Mielcarek, David G. Maloney, Rainer Storb
Publikováno v:
Haematologica, Vol 104, Iss 2 (2019)
We previously reported initial results in 102 multiple myeloma (MM) patients treated with sequential high-dose melphalan and autologous hematopoietic cell transplantation followed by 200 cGy total body irradiation with or without fludarabine 90 mg/m2
Externí odkaz:
https://doaj.org/article/16ae65b124174a7db168e63d44d26e82
Autor:
Samuel Strober, Edgar G. Engleman, Robert N. Negrin, Judith A. Shizuru, Sussan Dejbakhsh-Jones, Kent Jensen, Holbrook Kohrt, Nigel Zhang, Suparna Dutt, G-One Ahn, Justin Kenkel, Antonia M.S. Mueller, Jeanette Baker, Alexander Filatenkov
Supplementary Figures 1-4. Supplementary Figure 1. In vitro suppressive function of tumor-infiltrating MDSC 3 days after LTI, and analysis of CD8+CD11+ dendritic cell tumor infiltration after LTI. Supplementary Figure 2. PDL-1 and CD62L expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102d71174f740652bc7679ee11b40dbc
https://doi.org/10.1158/1078-0432.22456569
https://doi.org/10.1158/1078-0432.22456569
Autor:
Samuel Strober, Edgar G. Engleman, Robert N. Negrin, Judith A. Shizuru, Sussan Dejbakhsh-Jones, Kent Jensen, Holbrook Kohrt, Nigel Zhang, Suparna Dutt, G-One Ahn, Justin Kenkel, Antonia M.S. Mueller, Jeanette Baker, Alexander Filatenkov
Purpose: The goals of the study were to elucidate the immune mechanisms that contribute to desirable complete remissions of murine colon tumors treated with single radiation dose of 30 Gy. This dose is at the upper end of the ablative range used clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b50f8ac4d8fe37fffed567dbb948986b
https://doi.org/10.1158/1078-0432.c.6523350.v1
https://doi.org/10.1158/1078-0432.c.6523350.v1
Autor:
Samuel Strober, Edgar G. Engleman, Robert N. Negrin, Judith A. Shizuru, Sussan Dejbakhsh-Jones, Kent Jensen, Holbrook Kohrt, Nigel Zhang, Suparna Dutt, G-One Ahn, Justin Kenkel, Antonia M.S. Mueller, Jeanette Baker, Alexander Filatenkov
Figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f612b1ad519e3903f19956e44f30aac
https://doi.org/10.1158/1078-0432.22456572
https://doi.org/10.1158/1078-0432.22456572