Dissecting the Gene Expression, Localization, Membrane Topology, and Function of the Plasmodium falciparum STEVOR Protein Family

Autor: J. Stephan Wichers, Judith A. M. Scholz, Jan Strauss, Susanne Witt, Andrés Lill, Laura-Isabell Ehnold, Niklas Neupert, Benjamin Liffner, Renke Lühken, Michaela Petter, Stephan Lorenzen, Danny W. Wilson, Christian Löw, Catherine Lavazec, Iris Bruchhaus, Egbert Tannich, Tim W. Gilberger, Anna Bachmann

Publikováno v: mBio, Vol 10, Iss 4 (2019)

ABSTRACT During its intraerythrocytic development, the malaria parasite Plasmodium falciparum exposes variant surface antigens (VSAs) on infected erythrocytes to establish and maintain an infection. One family of small VSAs is the polymorphic STEVOR

Externí odkaz: https://doaj.org/article/517410248da74ba7892762b5ae7fb344

Dissecting the Gene Expression, Localization, Membrane Topology, and Function of the Plasmodium falciparum STEVOR Protein Family

Autor: Benjamin Liffner, Jan Strauss, Danny W. Wilson, Renke Lühken, J. Stephan Wichers, Tim W. Gilberger, Egbert Tannich, Michaela Petter, Christian Löw, Anna Bachmann, Stephan Lorenzen, Susanne Witt, Catherine Lavazec, Judith A. M. Scholz, Laura-Isabell Ehnold, Andrés Lill, Iris Bruchhaus, Niklas Neupert

Publikováno v: mBio, Vol 10, Iss 4 (2019)
mBio, Vol 10, Iss 4, p e01500-19 (2019)
mBio
mBio, American Society for Microbiology, 2019, 10 (4), ⟨10.1128/mBio.01500-19⟩
mBio, 10 (4). Art.Nr. e01500-19.

Malaria claims about half a million lives each year. Plasmodium falciparum, the causative agent of the most severe form of the disease, uses proteins that are translocated to the surface of infected erythrocytes for immune evasion. To circumvent the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd2ae0bdf31f66c3e7cc8f2de545540
https://journals.asm.org/doi/10.1128/mBio.01500-19

Mosquito Passage Dramatically Changes var Gene Expression in Controlled Human Plasmodium falciparum Infections

Autor: Anna, Bachmann, Michaela, Petter, Ralf, Krumkamp, Meral, Esen, Jana, Held, Judith A M, Scholz, Tao, Li, B Kim Lee, Sim, Stephen L, Hoffman, Peter G, Kremsner, Benjamin, Mordmüller, Michael F, Duffy, Egbert, Tannich

Publikováno v: PLoS pathogens, 12(4): e1005538
PLoS Pathogens, Vol 12, Iss 4, p e1005538 (2016)
PLoS Pathogens

Virulence of the most deadly malaria parasite Plasmodium falciparum is linked to the variant surface antigen PfEMP1, which is encoded by about 60 var genes per parasite genome. Although the expression of particular variants has been associated with d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b7154378f6ad8f75e3582c0575541183
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1005538#sec016