Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Judith A, Pratt"'
Autor:
Rebecca L. Openshaw, David M. Thomson, Greg C. Bristow, Emma J. Mitchell, Judith A. Pratt, Brian J. Morris, Neil Dawson
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Autism spectrum disorders are more common in males, and have a substantial genetic component. Chromosomal 16p11.2 deletions in particular carry strong genetic risk for autism, yet their neurobiological impact is poorly characterised, particu
Externí odkaz:
https://doaj.org/article/a9c33b7142af4f94937b2541091f6e9d
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 3 (2022)
In schizophrenia, subjects show reduced ability to evaluate and update risk/reward contingencies, showing correspondingly suboptimal performance in the Iowa gambling task. JNK signalling gene variants are associated with schizophrenia risk, and JNK m
Externí odkaz:
https://doaj.org/article/9a76da6a05ce411aafb7551f75a0602d
Autor:
Rebecca L. Openshaw, Jaedeok Kwon, Alison McColl, Josef M. Penninger, Jonathan Cavanagh, Judith A. Pratt, Brian J. Morris
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-11 (2019)
Abstract Background Important insight into the mechanisms through which gene-environmental interactions cause schizophrenia can be achieved through preclinical studies combining prenatal immune stimuli with disease-related genetic risk modifications.
Externí odkaz:
https://doaj.org/article/e4491777a70e43c38bdab2c69e8264c6
Autor:
Greg C. Bristow, David M. Thomson, Rebecca L. Openshaw, Emma J. Mitchell, Judith A. Pratt, Neil Dawson, Brian J. Morris
Publikováno v:
Cell Reports, Vol 31, Iss 3, Pp - (2020)
Summary: Chromosome 16p11.2 duplications dramatically increase risk for schizophrenia, but the mechanisms remain largely unknown. Here, we show that mice with an equivalent genetic mutation (16p11.2 duplication mice) exhibit impaired hippocampal-orbi
Externí odkaz:
https://doaj.org/article/7728d8dbc8bd473aafcc7b7820bf4f24
Publikováno v:
Journal of psychopharmacology (Oxford, England). 36(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8cc1303c3735d2aec363b60e0661cdc
https://pubmed.ncbi.nlm.nih.gov/35686684
https://pubmed.ncbi.nlm.nih.gov/35686684
Perineuronal nets (PNNs) are specialised extracellular matrix structures which preferentially enwrap fast-spiking (FS) parvalbumin interneurons and have diverse roles in the cortex. PNN maturation coincides with closure of the critical period of cort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906cc428893e26f96fbc0dfc8c7c0e28
https://strathprints.strath.ac.uk/79924/1/Willis_etal_MN_2022_Enzymatic_degradation_of_cortical_perineuronal_nets.pdf
https://strathprints.strath.ac.uk/79924/1/Willis_etal_MN_2022_Enzymatic_degradation_of_cortical_perineuronal_nets.pdf
Publikováno v:
Journal of Psychopharmacology (Oxford, England)
Background: Aside from regulating circadian rhythms, melatonin also affects cognitive processes, such as alertness, and modulates the brain circuitry underlying psychiatric diseases, such as depression, schizophrenia and bipolar disorder, via mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0563bec884aa0ca1d392956c7429c798
https://pubmed.ncbi.nlm.nih.gov/34304635
https://pubmed.ncbi.nlm.nih.gov/34304635
Autor:
Greer S Kirshenbaum, Neil Dawson, Jonathan G L Mullins, Tom H Johnston, Mark J Drinkhill, Ian J Edwards, Susan H Fox, Judith A Pratt, Jonathan M Brotchie, John C Roder, Steven J Clapcote
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e60141 (2013)
Missense mutations in ATP1A3 encoding Na(+),K(+)-ATPase α3 have been identified as the primary cause of alternating hemiplegia of childhood (AHC), a motor disorder with onset typically before the age of 6 months. Affected children tend to be of shor
Externí odkaz:
https://doaj.org/article/f77497bbfa82468199347510a9502a64
Autor:
David M. Thomson, Clotilde Mannoury la Cour, Marianna Kouskou, Judith A. Pratt, Rebecca L. Openshaw, Millan Mark, Emma J Mitchell, Brian J. Morris
Publikováno v:
Genes, Brain and Behavior. 20
The GPR88 orphan G protein-coupled receptor is expressed throughout the striatum, being preferentially localised in medium spiny neurons. It is also present in lower densities in frontal cortex and thalamus. Rare mutations in humans suggest a role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9772bb71c17fb72c5733c3738c1a3ccf
https://doi.org/10.1111/gbb.12710
https://doi.org/10.1111/gbb.12710