Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Judith, Kasir"'
Autor:
Ilona Patursky-Polischuk, Judith Kasir, Rachel Miloslavski, Zvi Hayouka, Mirit Hausner-Hanochi, Miri Stolovich-Rain, Pinchas Tsukerman, Moshe Biton, Rajini Mudhasani, Stephen N Jones, Oded Meyuhas
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109410 (2014)
TOP mRNAs encode components of the translational apparatus, and repression of their translation comprises one mechanism, by which cells encountering amino acid deprivation downregulate the biosynthesis of the protein synthesis machinery. This mode of
Externí odkaz:
https://doaj.org/article/7f434f823d2c4b7eab53b54260856367
Autor:
Igor Ruvinsky, Maximiliano Katz, Avigail Dreazen, Yuval Gielchinsky, Ann Saada, Nanette Freedman, Eyal Mishani, Gabriel Zimmerman, Judith Kasir, Oded Meyuhas
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5618 (2009)
BACKGROUND: Mice, whose ribosomal protein S6 cannot be phosphorylated due to replacement of all five phosphorylatable serine residues by alanines (rpS6(P-/-)), are viable and fertile. However, phenotypic characterization of these mice and embryo fibr
Externí odkaz:
https://doaj.org/article/3f4b80cffa164f35b31eab7280f36765
Autor:
Hannah Rahamimoff, M. Eskin-Shwartz, Chava Kimchi-Sarfaty, Benayahu Elbaz, A. Alperovich, Michael M. Gottesman, Judith Kasir, Y. Lichtenstein
Publikováno v:
Annals of the New York Academy of Sciences. 1099:204-214
Cyclosporin A (CsA) is an immunosuppressive drug commonly given to transplant patients. Its application is accompanied by severe side effects related to calcium, among them hypertension and nephrotoxicity. The Na + /Ca 2+ exchanger (NCX) is a major c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ff77af51e8deee126c8011b2994f31
https://doi.org/10.1196/annals.1387.046
https://doi.org/10.1196/annals.1387.046
Publikováno v:
Bone Marrow Transplantation. 38:359-364
Although the use of non-myeloablative stem cell transplantation (NST) reduces the severity of graft-versus-host disease (GVHD), GVHD remains a major complication following allogeneic transplantation. Since following NST in comparison with myeloablati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52798addc0ef74449e54ea54fea504cb
https://doi.org/10.1038/sj.bmt.1705449
https://doi.org/10.1038/sj.bmt.1705449
Publikováno v:
Annals of the New York Academy of Sciences. 976:176-186
The rat Na(+)/Ca(2+) exchanger isoforms of the NCX1 gene have 14 cysteine residues. Each of these cysteines can be mutated individually to alanine or serine without loss of functional expression in transfected HEK293 cells. Yet sequential exchange st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ea600598e4faa8010ad440ded0fcda5
https://doi.org/10.1111/j.1749-6632.2002.tb04739.x
https://doi.org/10.1111/j.1749-6632.2002.tb04739.x
Autor:
Lola Weiss, Michael Y. Shapira, Shimon Slavin, Ester Hirshfeld, Judith Kasir, Reuven Or, Igor B. Resnick, Michael Zeira
Publikováno v:
Cancer Immunology, Immunotherapy. 54:383-388
Background: Graft-versus-leukemia (GVL) effect is an essential component in the course of allogeneic stem cell transplantation (SCT). However, both prevention and treatment of established graft-versus-host disease (GVHD), including with drugs such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a1d42f43c105ccf961f707dcac2926
https://doi.org/10.1007/s00262-004-0614-9
https://doi.org/10.1007/s00262-004-0614-9
Publikováno v:
Journal of Biological Chemistry. 277:2505-2510
Cyclosporin A (CsA) treatment of HEK 293 cells expressing the rat heart RHE-1 (NCX1.1, EMBL accession number ) or the rat brain RBE-2 (NCX1.5, GenBank(TM) accession number ) Na(+)-Ca(2+) exchanger inhibited their transport activity in a concentration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10126f764d19f82966edc961a7be6cf7
https://doi.org/10.1074/jbc.m109154200
https://doi.org/10.1074/jbc.m109154200
Autor:
Stephen N. Jones, Yifat Iluz, Elad Cohen, Judith Kasir, Rajini Mudhasani, Ola Larsson, Markus A. Rüegg, Oded Meyuhas, Arjuna Rajakumar, Ivan Topisirovic, Nadine Cybulski, Rachel Miloslavski, Zvi Hayouka, Valentina Gandin, Adam Avraham
Cells encountering hypoxic stress conserve resources and energy by downregulating the protein synthesis. Here we demonstrate that one mechanism in this response is the translational repression of TOP mRNAs that encode components of the translational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e173921ccfbab996340cc012a4f0c49a
https://europepmc.org/articles/PMC4034726/
https://europepmc.org/articles/PMC4034726/
Publikováno v:
Journal of Biological Chemistry. 276:9572-9579
Membrane permeable N-ethylmaleimide (NEM) and (2-aminoethyl)methanethiosulfonatehydrobromide (MTSEA) inhibited the rat brain Na(+)-Ca(2+) exchanger RBE-2 (NCX1.5) expressed in HEK 293 cells in a dose dependent manner. 50% inhibition was obtained at 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827254bbe2179756599f71ed3c8a1c65
https://doi.org/10.1074/jbc.m007823200
https://doi.org/10.1074/jbc.m007823200
Publikováno v:
Journal of Biological Chemistry. 274:24873-24880
The C terminus of the rat brain Na(+)-Ca(2+) exchanger (RBE-1; NCX1. 4) (amino acids 875-903) is modeled to contain the last transmembrane alpha helix (amino acids 875-894) and an intracellular extramembraneous tail of 9 amino acids (895-903). Trunca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e73b8da02ad7c64b51c49115317875f0
https://doi.org/10.1074/jbc.274.35.24873
https://doi.org/10.1074/jbc.274.35.24873