Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Judith, Haendeler"'
Autor:
André Nguyen Dietzsch, Hadi Al-Hasani, Joachim Altschmied, Katharina Bottermann, Jana Brendler, Judith Haendeler, Susanne Horn, Isabell Kaczmarek, Antje Körner, Kerstin Krause, Kathrin Landgraf, Diana Le Duc, Laura Lehmann, Stefan Lehr, Stephanie Pick, Albert Ricken, Rene Schnorr, Angela Schulz, Martina Strnadová, Akhil Velluva, Heba Zabri, Torsten Schöneberg, Doreen Thor, Simone Prömel
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide prevalence. Understanding the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological inter
Externí odkaz:
https://doaj.org/article/b3c4ff1f595a49f8b5c14bc0d3761921
Autor:
Dennis Merk, Fiona Frederike Cox, Philipp Jakobs, Simone Prömel, Joachim Altschmied, Judith Haendeler
Publikováno v:
Antioxidants, Vol 13, Iss 4, p 443 (2024)
The endothelium, the innermost cell layer of blood vessels, is not only a physical barrier between the bloodstream and the surrounding tissues but has also essential functions in vascular homeostasis. Therefore, it is not surprising that endothelial
Externí odkaz:
https://doaj.org/article/7d41ff5f850d4b349122e2854d517c0f
Autor:
Dennis Merk, Jan Greulich, Annika Vierkant, Fiona Cox, Olaf Eckermann, Florian von Ameln, Nadine Dyballa-Rukes, Joachim Altschmied, Niloofar Ale-Agha, Philipp Jakobs, Judith Haendeler
Publikováno v:
Antioxidants, Vol 12, Iss 6, p 1244 (2023)
The maintenance of Thioredoxin-1 (Trx-1) levels, and thus of cellular redox homeostasis, is vital for endothelial cells (ECs) to prevent senescence induction. One hallmark of EC functionality, their migratory capacity, which depends on intact mitocho
Externí odkaz:
https://doaj.org/article/b92924c50b2547cd84703aa0bc08e0b4
Autor:
Natascia Ventura, Judith Haendeler
Publikováno v:
Cells, Vol 12, Iss 3, p 404 (2023)
Aging is an intricate and unavoidable phenomenon characterized by progressive accumulation of damage to cellular structural components with consequent decline in physiological functions and development of different pathological conditions, which lead
Externí odkaz:
https://doaj.org/article/7fb231a285624347bf97b085c12ebf75
Autor:
Andrey Bogorodskiy, Ivan Okhrimenko, Ivan Maslov, Nina Maliar, Dmitrii Burkatovskii, Florian von Ameln, Alexey Schulga, Philipp Jakobs, Joachim Altschmied, Judith Haendeler, Alexandros Katranidis, Ivan Sorokin, Alexey Mishin, Valentin Gordeliy, Georg Büldt, Wolfgang Voos, Thomas Gensch, Valentin Borshchevskiy
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Mitochondrial protein biogenesis relies almost exclusively on the expression of nuclear-encoded polypeptides. The current model postulates that most of these proteins have to be delivered to their final mitochondrial destination after their synthesis
Externí odkaz:
https://doaj.org/article/16e2a2506edb4cd58990e060d3ca145f
Autor:
Vanessa Brinkmann, Margherita Romeo, Lucie Larigot, Anne Hemmers, Lisa Tschage, Jennifer Kleinjohann, Alfonso Schiavi, Swantje Steinwachs, Charlotte Esser, Ralph Menzel, Sara Giani Tagliabue, Laura Bonati, Fiona Cox, Niloofar Ale-Agha, Philipp Jakobs, Joachim Altschmied, Judith Haendeler, Xavier Coumoul, Natascia Ventura
Publikováno v:
Antioxidants, Vol 11, Iss 4, p 613 (2022)
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor whose activity can be modulated by polyphenols, such as curcumin. AhR and curcumin have evolutionarily conserved effects on aging. Here, we investigated whether and how th
Externí odkaz:
https://doaj.org/article/fae757d48604452eaa2ef9ce87487b2d
Publikováno v:
Redox Biology, Vol 34, Iss , Pp 101543- (2020)
Telomerase consists of the catalytic subunit Telomerase Reverse Transcriptase (TERT) and the Telomerase RNA Component. Its canonical function is the prevention of telomere erosion. Over the last years it became evident that TERT is also present in ti
Externí odkaz:
https://doaj.org/article/ca38d376c1114e0a8adede24934625e3
Publikováno v:
Frontiers in Physiology, Vol 10 (2020)
Aging is the most important risk factor for the development of major life-threatening diseases such as cardiovascular disorders, cancer, and neurodegenerative disorders. The aging process is characterized by the accumulation of damage to intracellula
Externí odkaz:
https://doaj.org/article/dce95e14aaa04170b7682f8701cfa11e
Autor:
Fiona Frederike Cox, Angelina Misiou, Annika Vierkant, Niloofar Ale-Agha, Maria Grandoch, Judith Haendeler, Joachim Altschmied
Publikováno v:
Cells, Vol 11, Iss 3, p 342 (2022)
Cardiovascular diseases (CVDs) contribute to a large part of worldwide mortality. Similarly, two of the major risk factors for these diseases, aging and obesity, are also global problems. Aging, the gradual decline of body functions, is non-modifiabl
Externí odkaz:
https://doaj.org/article/ce070d1cc6234eab8593a70ef50fc28f
Autor:
Andrey Bogorodskiy, Ivan Okhrimenko, Dmitrii Burkatovskii, Philipp Jakobs, Ivan Maslov, Valentin Gordeliy, Norbert A. Dencher, Thomas Gensch, Wolfgang Voos, Joachim Altschmied, Judith Haendeler, Valentin Borshchevskiy
Publikováno v:
Cells, Vol 10, Iss 12, p 3528 (2021)
Mitochondria play a critical role in providing energy, maintaining cellular metabolism, and regulating cell survival and death. To carry out these crucial functions, mitochondria employ more than 1500 proteins, distributed between two membranes and t
Externí odkaz:
https://doaj.org/article/1466362e77944b6b96de255e8ac14b03