BRCA1 deficiency specific base substitution mutagenesis is dependent on translesion synthesis and regulated by 53BP1

Autor: Dan Chen, Judit Z. Gervai, Ádám Póti, Eszter Németh, Zoltán Szeltner, Bernadett Szikriszt, Zsolt Gyüre, Judit Zámborszky, Marta Ceccon, Fabrizio d’Adda di Fagagna, Zoltan Szallasi, Andrea L. Richardson, Dávid Szüts

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)

Loss of BRCA1 or BRCA2 results in genomic instability; however most studies have focused on the role of these proteins in double-strand break repair. Here the authors coupled cell line genetics and whole genome sequencing to investigate the formation

Externí odkaz: https://doaj.org/article/4d6fef3434494fd5bb14a0669bb5653f

Loss of BRCA1 or BRCA2 markedly increases the rate of base substitution mutagenesis and has distinct effects on genomic deletions

Autor: Marcin Krzystanek, Judit Zámborszky, Judit Z. Gervai, Charles Swanton, János M. Szalai-Gindl, Andrea L. Richardson, Bernadett Szikriszt, Orsolya Pipek, Zoltan Szallasi, Dezső Ribli, Dávid Szüts, István Csabai, Ádám Póti

Publikováno v: Oncogene
Zamborszky, J, Szikriszt, B, Gervai, J Z, Pipek, O, Poti, A, Krzystanek, M, Ribli, D, Szalai-Gindl, J M, Csabai, I, Szallasi, Z I, Swanton, C, Richardson, A L & Szuets, D 2017, ' Loss of BRCA1 or BRCA2 markedly increases the rate of base substitution mutagenesis and has distinct effects on genomic deletions ', Oncogene, vol. 36, no. 6, pp. 746-755 . https://doi.org/10.1038/onc.2016.243

Loss-of-function mutations in the BRCA1 and BRCA2 genes increase the risk of cancer. Owing to their function in homologous recombination repair, much research has focused on the unstable genomic phenotype of BRCA1/2 mutant cells manifest mainly as la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::618e1240e32b12194169749a0779ba8c
https://pubmed.ncbi.nlm.nih.gov/28650471