Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Judit Remenyi"'
Autor:
Judit Remenyi, Rangeetha Jayaprakash Naik, Jinhua Wang, Momchil Razsolkov, Alyssa Verano, Quan Cai, Li Tan, Rachel Toth, Samantha Raggett, Carla Baillie, Ryan Traynor, C. James Hastie, Nathanael S. Gray, J. Simon C. Arthur
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Janus Kinases (JAKs) have emerged as an important drug target for the treatment of a number of immune disorders due to the central role that they play in cytokine signalling. 4 isoforms of JAKs exist in mammalian cells and the ideal isoform
Externí odkaz:
https://doaj.org/article/66b7f58af7964f179690d10510378958
Autor:
Manikandan Periyasamy, Hetal Patel, Chun-Fui Lai, Van T.M. Nguyen, Ekaterina Nevedomskaya, Alison Harrod, Roslin Russell, Judit Remenyi, Anna Maria Ochocka, Ross S. Thomas, Frances Fuller-Pace, Balázs Győrffy, Carlos Caldas, Naveenan Navaratnam, Jason S. Carroll, Wilbert Zwart, R. Charles Coombes, Luca Magnani, Laki Buluwela, Simak Ali
Publikováno v:
Cell Reports, Vol 13, Iss 1, Pp 108-121 (2015)
Estrogen receptor α (ERα) is the key transcriptional driver in a large proportion of breast cancers. We report that APOBEC3B (A3B) is required for regulation of gene expression by ER and acts by causing C-to-U deamination at ER binding regions. We
Externí odkaz:
https://doaj.org/article/0888c564b94245ac837fe1a7d55a9dc2
Autor:
Gilles Gadea, Nikola Arsic, Kenneth Fernandes, Alexandra Diot, Sébastien M Joruiz, Samer Abdallah, Valerie Meuray, Stéphanie Vinot, Christelle Anguille, Judit Remenyi, Marie P Khoury, Philip R Quinlan, Colin A Purdie, Lee B Jordan, Frances V Fuller-Pace, Marion de Toledo, Maïlys Cren, Alastair M Thompson, Jean-Christophe Bourdon, Pierre Roux
Publikováno v:
eLife, Vol 5 (2016)
TP53 is conventionally thought to prevent cancer formation and progression to metastasis, while mutant TP53 has transforming activities. However, in the clinic, TP53 mutation status does not accurately predict cancer progression. Here we report, base
Externí odkaz:
https://doaj.org/article/f581c63f2c83491e9dc7660202f2310e
Autor:
Judit Remenyi, Mirjam W M van den Bosch, Oleg Palygin, Rajen B Mistry, Colin McKenzie, Andrew Macdonald, Gyorgy Hutvagner, J Simon C Arthur, Bruno G Frenguelli, Yuriy Pankratov
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62509 (2013)
miR-132 and miR-212 are two closely related miRNAs encoded in the same intron of a small non-coding gene, which have been suggested to play roles in both immune and neuronal function. We describe here the generation and initial characterisation of a
Externí odkaz:
https://doaj.org/article/109d47346eba47aea53f44d1ee754789
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33144 (2012)
MiRNAs can regulate gene expression through versatile mechanisms that result in increased or decreased expression of the targeted mRNA and it could effect the expression of thousands of protein in a particular cell. An increasing body of evidence sug
Externí odkaz:
https://doaj.org/article/843924bf49674c7f8e42cc0c71334745
Autor:
Simak Ali, R. Charles Coombes, Ian O. Ellis, Emad A. Rakha, Laki Buluwela, Sami Shousha, Frances Fuller-Pace, Louise J. Jones, Balázs Győrffy, Luca Magnani, Jennifer J. Gomm, Sally Smith, Judit Remenyi, Dena Jerjees, Claudia Busonero, Naina Patel, Jennifer H. Steel, Carolina Gemma, Alison Harrod, Manikandan Periyasamy, Chun-Fui Lai, Rezvan Abduljabbar, Hetal Patel
Supplementary Table 1. Multivariate Cox Regression Analysis for Time to Distant Metastasis (TTDM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de403ba18d48c3e7e197a85a45eed3a
https://doi.org/10.1158/1078-0432.22458171.v1
https://doi.org/10.1158/1078-0432.22458171.v1
Autor:
Simak Ali, R. Charles Coombes, Ian O. Ellis, Emad A. Rakha, Laki Buluwela, Sami Shousha, Frances Fuller-Pace, Louise J. Jones, Balázs Győrffy, Luca Magnani, Jennifer J. Gomm, Sally Smith, Judit Remenyi, Dena Jerjees, Claudia Busonero, Naina Patel, Jennifer H. Steel, Carolina Gemma, Alison Harrod, Manikandan Periyasamy, Chun-Fui Lai, Rezvan Abduljabbar, Hetal Patel
Supplementary Figure 1. Expression of CDK7, cyclin H and MAT1 is elevated in breast cancer. Supplementary Figure 2. Relationship between mRNA levels of CDK7, cyclin H and MAT1 in breast cancer. Supplementary Figure 3. Profiling of CDK7, Cyclin H and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022b0dc1d4bc3716a7cb72ef996390db
https://doi.org/10.1158/1078-0432.22458174.v1
https://doi.org/10.1158/1078-0432.22458174.v1
Autor:
Simak Ali, R. Charles Coombes, Ian O. Ellis, Emad A. Rakha, Laki Buluwela, Sami Shousha, Frances Fuller-Pace, Louise J. Jones, Balázs Győrffy, Luca Magnani, Jennifer J. Gomm, Sally Smith, Judit Remenyi, Dena Jerjees, Claudia Busonero, Naina Patel, Jennifer H. Steel, Carolina Gemma, Alison Harrod, Manikandan Periyasamy, Chun-Fui Lai, Rezvan Abduljabbar, Hetal Patel
Purpose: CDK-activating kinase (CAK) is required for the regulation of the cell cycle and is a trimeric complex consisting of cyclin-dependent kinase 7 (CDK7), Cyclin H, and the accessory protein, MAT1. CDK7 also plays a critical role in regulating t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa678e7db7bda605727ecce058e9bd1
https://doi.org/10.1158/1078-0432.c.6523854.v1
https://doi.org/10.1158/1078-0432.c.6523854.v1
Autor:
Róbert Nagy, Andrea Kun-Nemes, Erzsébet Szőllősi, Piroska Bíróné Molnár, Zoltán Cziáky, Eszter Murányi, Péter Sipos, Judit Remenyik
Publikováno v:
Heliyon, Vol 10, Iss 16, Pp e35807- (2024)
A comprehensive study of sorghum bran and flour was performed to explore the secondary metabolite profiles of differently coloured genotypes and to evaluate the variability in the antioxidant properties based on differences in polarity and solubility
Externí odkaz:
https://doaj.org/article/28564d05a34746f9b4e85d2304dbce22
Autor:
Marek Gierlinski, Sara J. Brown, William V. Nicholson, Angus I. Lamond, Christian Cole, Susan E. Bray, Judit Remenyi, James Abbott, John A. McGrath, Sara ten Have, Sheila C. Wright, Mateusz Glok, Martina S. Elias, Alan R. Prescott, Sharon Edwards, Phillip D. Whitfield, Lavinia Paternoster
Publikováno v:
The Journal of Allergy and Clinical Immunology
Elias, M S, Wright, S C, Remenyi, J, Abbott, J C, Bray, S E, Cole, C, Edwards, S, Gierlinski, M, Glok, M, McGrath, J A, Nicholson, W V, Paternoster, L, Prescott, A R, Have, S T, Whitfield, P D, Lamond, A I & Brown, S J 2019, ' EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis ', Journal of Allergy and Clinical Immunology, vol. 144, no. 2, pp. 470-481 . https://doi.org/10.1016/j.jaci.2019.05.024
Elias, M S, Wright, S C, Remenyi, J, Abbott, J C, Bray, S E, Cole, C, Edwards, S, Gierlinski, M, Glok, M, McGrath, J A, Nicholson, W V, Paternoster, L, Prescott, A R, Have, S T, Whitfield, P D, Lamond, A I & Brown, S J 2019, ' EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis ', Journal of Allergy and Clinical Immunology, vol. 144, no. 2, pp. 470-481 . https://doi.org/10.1016/j.jaci.2019.05.024
Background Atopic dermatitis (AD) is a common, complex, and highly heritable inflammatory skin disease. Genome-wide association studies offer opportunities to identify molecular targets for drug development. A risk locus on chromosome 11q13.5 lies be