Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Judit Laszy"'
Autor:
Attila Sándor Halász, Amrita Ágnes Bobok, Zoltán Szakács, István Greiner, Zoltán Orgován, Mónika Vastag, Sándor Kolok, Zoltán Béni, Gábor Wágner, Mónika L. Mikó-Bakk, Zsolt Szombathelyi, Attila Bielik, Krisztina Gál, Katalin Nogradi, György M. Keserű, Ottilia Balázs, Katalin Saghy, János Kóti, György T. Balogh, Judit Laszy, Mikhail Krasavin, György Domány, Janos Galambos
Publikováno v:
Journal of Medicinal Chemistry. 60:2470-2484
Negative allosteric modulators (NAM) of metabotropic glutamate receptor 5 (mGluR5) have been implicated as a potential pharmacotherapy for a number of psychiatric diseases, including anxiety and depression. Most of the mGluR5 NAM clinical candidates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3dc984e3e83f573a4bc24f797febd2
https://doi.org/10.1021/acs.jmedchem.6b01858
https://doi.org/10.1021/acs.jmedchem.6b01858
Autor:
Balázs Lendvai, Anna E. Káncz, Pál Tapolcsányi, Zoltán Béni, János Kóti, Marta Than, Éva Bozó, János Éles, István Greiner, Judit Laszy, Zsolt Némethy, Sándor Mahó, András Visegrády, Márton Vass, Gyula Bugovits, György Lévay, István Ledneczki, Anikó Pocsai, Balázs Krámos, Ágota Szájli, Mónika Vastag, Patrik Holm, Sándor Kolok, Eszter Gábor, Ottilia Balázs, Anita Horváth, József Nagy
Publikováno v:
European Journal of Medicinal Chemistry. 214:113189
The paper focuses on the scaffold hopping-based discovery and characterization of novel nicotinic alpha 7 receptor positive modulator (α7 nAChR PAM) ligands around the reference molecule (A-867744). First, substantial efforts were carried out to ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ad9ffda37f8a3d089c88187d8a3c0f
https://doi.org/10.1016/j.ejmech.2021.113189
https://doi.org/10.1016/j.ejmech.2021.113189
Autor:
Pál Kocsis, Zsófia Pozsgay, Judit Laszy, Károly Tihanyi, Istvan Gyertyan, Nikolett Hegedűs, Szabolcs David, Dávid Gajári, Levente Deli
Publikováno v:
Journal of Psychopharmacology. 29:447-455
There is a huge unmet need to understand and treat pathological cognitive impairment. The development of disease modifying cognitive enhancers is hindered by the lack of correct pathomechanism and suitable animal models. Most animal models to study c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c77ab1b2e12bf66795e9c4a16ae77a
https://doi.org/10.1177/0269881114565652
https://doi.org/10.1177/0269881114565652
Autor:
Gábor Szabó, Izabella Obál, Mária A. Deli, László Fábián, Szilvia Veszelka, Csongor S. Ábrahám, Zoltán Urbányi, Judit Laszy, Tamas Pazmany, Laszlo Nemeth
Publikováno v:
European Journal of Microbiology and Immunology. 3:281-289
Serum amyloid P component (SAP), a member of the innate immune system, does not penetrate the brain in physiological conditions; however, SAP is a stabilizing component of the amyloid plaques in neurodegenerative diseases. We investigated the cerebro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5720a20063a2ac49ee8974286368c59
https://doi.org/10.1556/eujmi.3.2013.4.8
https://doi.org/10.1556/eujmi.3.2013.4.8
Autor:
Mária Zájer-Balázs, Károly Tihanyi, Katalin Saghy, Mónika Vastag, Katalin Nogradi, Istvan Vago, Bela Kiss, Margit Kapás, István Greiner, Larisza Gémesi, Zsolt Szombathelyi, György M. Keserű, Éva Ágai-Csongor, Janos Galambos, Eva Schmidt, Istvan Gyertyan, György Domány, Judit Laszy, Aniko Gere, István Laszlovszky
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3437-3440
Medicinal chemistry optimization of an impurity isolated during the scale-up synthesis of a pyridylsulfonamide type dopamine D3/D2 compound (1) led to a series of new piperazine derivatives having affinity to both dopamine D3 and D2 receptors. Severa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b1e35c4f2a245e7be871e82a9552b3
https://doi.org/10.1016/j.bmcl.2012.03.104
https://doi.org/10.1016/j.bmcl.2012.03.104
Autor:
Istvan Gyertyan, Bela Kiss, György Szabó, Mónika Vastag, Eva Hegyi, Dóra Payer-Lengyel, Krisztina Vukics, Attila Szemzö, Judit Szikra, Judit Laszy, Janos Fischer, Peter Erdelyi, Balázs Varga
Publikováno v:
Journal of Medicinal Chemistry. 52:4329-4337
Obesity is a major clinical problem in the western world, and many molecular targets have been explored in the search for effective therapeutic agents. One of these, antagonism of the cannabinoid 1 (CB1) receptor, rose to prominence following reports
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdada94417ac61829f01e55ec7a7ef54
https://doi.org/10.1021/jm900179y
https://doi.org/10.1021/jm900179y
Autor:
András Nemes, László Czibula, Csaba Szántay, Jr., Anikó Gere, Béla Kiss, Judit Laszy, István Gyertyán, Zsolt Szombathelyi, Csaba Szántay
Publikováno v:
Journal of Medicinal Chemistry. 51:479-486
A series of trans-2'-hydroxyethyl and 2'-acyloxyethyl apovincaminates 4b- f and 7b- f has been synthesized and evaluated for their antioxidant and antiamnesic effects. The new esters were prepared from 4a and 7a ethyl esters or from the corresponding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85310b52d8716f0190137ed1ffb6c130
https://doi.org/10.1021/jm070618k
https://doi.org/10.1021/jm070618k
Autor:
Istvan Laszlovszky, Ildikó Magdó, Eva Schmidt, György M. Keserü, Györgyi Ignacz-Szendrei, Katalin Nogradi, Judit Laszy, Larisza Gémesi, Attila Bielik, István Greiner, Éva Ágai-Csongor, György Domány, Mária Zájer-Balázs, Janos Galambos, Istvan Vago, Istvan Gyertyan, Bela Kiss, Katalin Saghy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5340-5344
A novel series of arylsulfonamides was prepared either by automated parallel or by traditional solution-phase synthesis. Several members of this compound library were identified as high-affinity dopamine D3 and D2 receptor ligands. The most interesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6050a05a57420e300744aed9be2987ff
https://doi.org/10.1016/j.bmcl.2007.08.015
https://doi.org/10.1016/j.bmcl.2007.08.015
Autor:
János Éles, Istvan Gyertyan, Károly Tihanyi, Pál Kocsis, Nikolett Hegedüs, Zsófia Pozsgay, Szabolcs David, Judit Laszy, Levente Deli, Dávid Gajári
Concordant results of functional magnetic resonance imaging (fMRI) and behavioral tests prove that some non-blood-brain barrier-penetrating drugs produce robust central nervous system (CNS) effects. The anticholinergic scopolamine interferes with lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b85dea4c1438c5c8e221db0ea526828
https://europepmc.org/articles/PMC4050244/
https://europepmc.org/articles/PMC4050244/
Autor:
Károly Tihanyi, Zsolt Szombathelyi, Tamás Szabados, Margit Kapás, Eva Csongor, Mária Zájer-Balázs, Istvan Gyertyan, Katalin Saghy, Judit Laszy, Bela Kiss, György Domány, Gabriella Pásztor, Larisza Gémesi, Györgyi Szabó
Publikováno v:
Neurochemistry international. 59(6)
We investigated the in vivo effects of orally administered cariprazine (RGH-188; trans-N-{4-[2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl]-cyclohexyl}-N',N'-dimethyl-urea), a D(3)/D(2) dopamine receptor partial agonist with ∼10-fold preference f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7925cf6fbe99719646deff89a09cdd88
https://pubmed.ncbi.nlm.nih.gov/21767587
https://pubmed.ncbi.nlm.nih.gov/21767587