Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Judit Kralovánszky"'
Publikováno v:
Magyar onkologia. 61(4)
The present review about the history of anticancer drug research in Hungary intends to call attention to the importance of studies on their mode of action. Several lines of evidence suggest that clinically usable oncopharmacological properties could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8c3977f7b4f667a7b935abb324ff34c4
https://pubmed.ncbi.nlm.nih.gov/29257158
https://pubmed.ncbi.nlm.nih.gov/29257158
Autor:
Vilmos Adleff, István Láng, Milena Gusella, Jon Trærup Andersen, Morten Petersen, Kasper Brødbæk, Barna Budai, Erika Hitre, Shoaib Afzal, Laura Bertolaso, Enikő Orosz, Ulla Vogel, Carmen Barile, Judit Kralovánszky, Henrik E. Poulsen, Ben Vainer, Roberto Padrini, Felice Pasini, Søren Astrup Jensen, Espen Jimenez-Solem
Publikováno v:
Pharmacogenomics. 12:1257-1267
Aim: The purpose of this study was to investigate whether specific combinations of polymorphisms in 5-fluorouracil (5-FU) metabolism-related genes were associated with outcome in 5-FU-based adjuvant treatment of colorectal cancer. Methods: We analyze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3205d812a8fc00d860bf70cc826d3795
https://doi.org/10.2217/pgs.11.83
https://doi.org/10.2217/pgs.11.83
Publikováno v:
Spectrochimica Acta Part B: Atomic Spectroscopy. 63:1480-1484
The elemental content of Cu, Fe and Zn in two human adenocarcinoma cell lines was investigated by total reflection X-ray fluorescence (TXRF) spectrometry. Cancer cells were sedimented directly to the quartz plates using a modified cytospin slide hold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d26745262d41cd4a5e0e11a49b108110
https://doi.org/10.1016/j.sab.2008.10.025
https://doi.org/10.1016/j.sab.2008.10.025
Autor:
Judit Kralovánszky
Publikováno v:
Magyar Onkológia. 52:9-18
Antiproliferative cytotoxic agents, of which several are still in clinical practice nowadays, could be characterized by low selectivity, narrow therapeutic index, medium or serious side effects and rapid formation of resistance. In the limited effica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4dd36407da9e2c07e116c4da5b2bb12
https://doi.org/10.1556/monkol.52.2008.1.3
https://doi.org/10.1556/monkol.52.2008.1.3
Autor:
Alexandra Fullár, Ágnes Márk, Zoltán Hujber, Károly Vékey, Anna Sebestyén, András Jeney, Norbert Szoboszlai, Cs. Kriston, E. Pap, Ilona Kovalszky, Julia Olah, Judit Kralovánszky
Publikováno v:
Cancer Cell International
Europe PubMed Central
Europe PubMed Central
Background Alterations in cellular metabolism are considered as hallmarks of cancers, however, to recognize these alterations and understand their mechanisms appropriate techniques are required. Our hypothesis was to determine whether dominant bioene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d480b570a895fcee9e2413952832b05b
https://pubmed.ncbi.nlm.nih.gov/26869854
https://pubmed.ncbi.nlm.nih.gov/26869854
Autor:
Judit Kralovánszky, Vilmos Adleff, Barna Budai, Miklós Kásler, István Láng, Zsolt Orosz, Fruzsina Gyergyay, Zsolt Horváth, Ferenc Czeglédi, Tibor Kovács, Erika Hitre, József Lövey
Publikováno v:
Pharmacogenetics and Genomics. 15:723-730
The present study aimed to prospectively investigate the influence of thymidylate synthase (TS) polymorphisms (5'-TSER, 3'-TSUTR) on the disease-free survival (DFS) and overall survival (OS) of patients with colorectal cancer (CRC) who were treated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905b6cea043c4e93799b83bc8ecd9978
https://doi.org/10.1097/01.fpc.0000175598.42141.59
https://doi.org/10.1097/01.fpc.0000175598.42141.59
Publikováno v:
International Journal of Cancer. 108:852-856
Thymidylate synthase (TS) gene polymorphisms are important as prognostic factors in cancer chemotherapy, but recent results describe that the TS enhancer region (TSER) polymorphic genotypes may also modulate risk for malignancies. Two functionally im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fed7e8b2374c6e4f882e29b934b9f6f
https://doi.org/10.1002/ijc.11641
https://doi.org/10.1002/ijc.11641
Autor:
Csilla Katona, Erzsébet Pandi, András Jeney, Jean Louis Fischel, Judit Kralovánszky, Ferenc Timár, Gérard Milano
Publikováno v:
Anti-Cancer Drugs. 10:561-568
The purpose of the present study was to clarify the significance of the inhibition of dihydropyrimidine dehydrogenase (DPD) in the modulation of 5-fluorouracil (5-FU) action by 5-ethyl-2'-deoxyuridine (EUdR). Four human cell lines, which differed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3df35df4d4f2933a9fc88ecb5712ee
https://doi.org/10.1097/00001813-199907000-00008
https://doi.org/10.1097/00001813-199907000-00008
Autor:
Vilmos Adleff, Judit Kralovánszky, Éva Pap, István Láng, Viktor Komlósi, Andrea Réti, Erika Hitre, Tünde Nagy, Barna Budai
Publikováno v:
Pharmacogenetics and genomics. 22(1)
The impact of thymidylate synthase (TYMS), methylenetetrahydrofolate reductase (MTHFR), and serine hydroxymethyltransferase 1 (SHMT1) gene polymorphisms and that of dihydropyrimidine dehydrogenase (DPD) enzyme activity, serum total homocysteine level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ed254b3b373fcf66984cdcff0c82fb
https://pubmed.ncbi.nlm.nih.gov/22044939
https://pubmed.ncbi.nlm.nih.gov/22044939
Publikováno v:
Cancer Chemotherapy and Pharmacology. 32:243-248
Selective protection of the normal host tissues from the toxic effects of anticancer agents would allow the use of higher, probably more effective, doses of the drugs. It has been demonstrated that delayed high-dose uridine administration after 5-flu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892b7451c8788419a8089b5bc4dfac6c
https://doi.org/10.1007/bf00685843
https://doi.org/10.1007/bf00685843