Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Judit Jimenez-Sainz"'
Autor:
Liana Goehring, Sarah Keegan, Sudipta Lahiri, Wenxin Xia, Michael Kong, Judit Jimenez-Sainz, Dipika Gupta, Ronny Drapkin, Ryan B. Jensen, Duncan J. Smith, Eli Rothenberg, David Fenyö, Tony T. Huang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract BRCA2 is a tumor suppressor protein responsible for safeguarding the cellular genome from replication stress and genotoxicity, but the specific mechanism(s) by which this is achieved to prevent early oncogenesis remains unclear. Here, we pro
Externí odkaz:
https://doaj.org/article/6eae7c91ca5e4e60a5079c4501597601
Autor:
Judit Jimenez-Sainz, Joshua Mathew, Gemma Moore, Sudipta Lahiri, Jennifer Garbarino, Joseph P Eder, Eli Rothenberg, Ryan B Jensen
Publikováno v:
eLife, Vol 11 (2022)
Pathogenic mutations in the BRCA2 tumor suppressor gene predispose to breast, ovarian, pancreatic, prostate, and other cancers. BRCA2 maintains genome stability through homology-directed repair (HDR) of DNA double-strand breaks (DSBs) and replication
Externí odkaz:
https://doaj.org/article/eee52955fae0447b99212376c3441014
Autor:
Jenny Kaur Singh, Sylvie M. Noordermeer, Judit Jimenez-Sainz, David G. Maranon, Matthias Altmeyer
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/2b489b8afe4f48c59963cbb87a2fc068
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
The BRCA2 germline missense variant, R3052W, resides in the DNA binding domain and has been previously classified as a pathogenic allele. In this study, we sought to determine how R3052W alters the cellular functions of BRCA2 in the DNA damage respon
Externí odkaz:
https://doaj.org/article/dcd6e2d5d5b44aa6908028ee563d0219
Autor:
James M. Daley, Judit Jimenez-Sainz, Weibin Wang, Adam S. Miller, Xiaoyu Xue, Kevin A. Nguyen, Ryan B. Jensen, Patrick Sung
Publikováno v:
Cell Reports, Vol 21, Iss 2, Pp 324-332 (2017)
Summary: DNA double-strand break repair by homologous recombination entails the resection of DNA ends to reveal ssDNA tails, which are used to invade a homologous DNA template. CtIP and its yeast ortholog Sae2 regulate the nuclease activity of MRE11
Externí odkaz:
https://doaj.org/article/7adf5d3e429c4767b4e4377fa860671d
Autor:
David Maranon, Judit Jimenez Sainz, Sylvie M. Noordermeer, Matthias Altmeyer, Jenny Kaur Singh
Publikováno v:
Frontiers Research Topics ISBN: 9782832500477
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::302eff2673fb00979b31ec5908ba1de0
https://doi.org/10.3389/978-2-83250-047-7
https://doi.org/10.3389/978-2-83250-047-7
Publikováno v:
STAR protocols. 3(2)
DNA fiber combing is a versatile technique that provides insight into replication fork dynamics at single-molecule resolution. DNA fibers are bound to silanized coverslips and combed, which straightens and aligns the fibers along a single axis. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72488858c5131634d24e6132f4417706
https://pubmed.ncbi.nlm.nih.gov/35573479
https://pubmed.ncbi.nlm.nih.gov/35573479
Autor:
David G. Maranon, Weibin Wang, Xuemei Song, Fengshan Liang, Lucy Lu, Yong Xiong, Eric C. Greene, Xiaoyong Chen, Yanhong Deng, Gary M. Kupfer, Judit Jimenez-Sainz, Patrick Sung, Chen Sheng, Claudia Wiese, Timsi Rao, Chu Jian Ma, Youngho Kwon, Weixing Zhao, Justin B. Steinfeld, Ryan B. Jensen
Publikováno v:
Nature. 550:360-365
The tumour suppressor complex BRCA1-BARD1 functions in the repair of DNA double-stranded breaks by homologous recombination. During this process, BRCA1-BARD1 facilitates the nucleolytic resection of DNA ends to generate a single-stranded template for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01847945b57be45e2790ca9e8eb46f43
https://doi.org/10.1038/nature24060
https://doi.org/10.1038/nature24060
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Homologous Recombination (HR) is a high-fidelity process with a range of biologic functions from generation of genetic diversity to repair of DNA double-strand breaks (DSBs). In mammalian cells, BRCA2 facilitates the polymerization of RAD51 onto ssDN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605b83cd8b55a65723a8a78c8ccec718
http://europepmc.org/articles/PMC6418147
http://europepmc.org/articles/PMC6418147