Sigma-1 Receptor Activation Is Protective against TGFβ2-Induced Extracellular Matrix Changes in Human Trabecular Meshwork Cells

Autor: Minh Ngoc Tran, Timea Medveczki, Balazs Besztercei, Gyorgy Torok, Attila J. Szabo, Xavier Gasull, Illes Kovacs, Andrea Fekete, Judit Hodrea

Publikováno v: Life, Vol 13, Iss 7, p 1581 (2023)

The trabecular meshwork (TM) route is the principal outflow egress of the aqueous humor. Actin cytoskeletal remodeling in the TM and extracellular matrix (ECM) deposition increase TM stiffness, outflow resistance, and elevate intraocular pressure (IO

Externí odkaz: https://doaj.org/article/f96803de5c6442e6ba0c523f26f6b606

Autologous apoptotic neutrophils inhibit inflammatory cytokine secretion by human dendritic cells, but enhance Th1 responses

Autor: Gyöngyike Emese Majai, Péter Gogolák, Márta Tóth, Judit Hodrea, Dorottya Horváth, László Fésüs, Éva Rajnavölgyi, Attila Bácsi

Publikováno v: FEBS Open Bio, Vol 10, Iss 8, Pp 1492-1502 (2020)

Neutrophils represent the most abundant cell type in peripheral blood and exhibit a remarkably brief (6–8 h) half‐life in circulation. The fundamental role of these professional phagocytes has been established in acute inflammation, based on thei

Externí odkaz: https://doaj.org/article/4fd08a48923d4aad8a000eb57479bf22

Sigma − 1 receptor activation as a new option for the treatment of glaucoma in preclinical models

Autor: Andrea Fekete, Minh N. Tran, Balazs Besztercei, Gyorgy Torok, Timea Medveczki, Anna Takácsi‐Nagy, Xavier Gasull, Attila J. Szabo, Illes Kovacs, Judit Hodrea

Publikováno v: Acta Ophthalmologica. 100

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5276ffb4e4b72e3af1d10699b91c2e7b
https://doi.org/10.1111/j.1755-3768.2022.15344

MO1019: Sigma-1 Receptor Agonists are Protective in a Rat Model of Kidney Transplantation

Autor: Tamas Lakat, Akos Roland Toth, Judit Hodrea, Laszlo Wagner, Attila Szabo, Andrea Fekete, Adam Hosszu

Publikováno v: Nephrology Dialysis Transplantation. 37

BACKGROUND AND AIMS End-stage renal disease affects nearly 2 million people worldwide. The disease is associated with an irreversible deterioration in renal function and can only be treated by dialysis or kidney transplantation (KTx). KTx is associat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f1f232d34c65ebb41e933354b09e57a
https://doi.org/10.1093/ndt/gfac088.021

Reduced O-GlcNAcylation and tubular hypoxia contribute to the antifibrotic effect of SGLT2 inhibitor dapagliflozin in the diabetic kidney

Autor: Federica Genovese, Dora Balogh, Sandor Koszegi, Attila J. Szabo, Lilla Lenart, Adam Hosszu, Judit Hodrea, Nadja Sparding, Andrea Fekete, László Wagner, Balázs Besztercei

Publikováno v: Hodrea, J, Balogh, D B, Hosszu, A, Lenart, L, Besztercei, B, Koszegi, S, Sparding, N, Genovese, F, Wagner, L J, Szabo, A J & Fekete, A 2020, ' Reduced O-GlcNAcylation and tubular hypoxia contribute to the antifibrotic effect of SGLT2 inhibitor dapagliflozin in the diabetic kidney ', American journal of physiology. Renal physiology, vol. 318, no. 4, pp. F1017-F1029 . https://doi.org/10.1152/ajprenal.00021.2020
American Journal of Physiology-Renal Physiology

Diabetic kidney disease is a worldwide epidemic, and therapies are incomplete. Clinical data suggest that improved renal outcomes by Na+-glucose cotransporter 2 inhibitor (SGLT2i) are partly beyond their antihyperglycemic effects; however, the mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031baa841634475b1012573f5554f7bf
https://doi.org/10.1152/ajprenal.00021.2020