Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Judit Grueso"'
Autor:
Marta Palafox, Laia Monserrat, Meritxell Bellet, Guillermo Villacampa, Abel Gonzalez-Perez, Mafalda Oliveira, Fara Brasó-Maristany, Nusaibah Ibrahimi, Srinivasaraghavan Kannan, Leonardo Mina, Maria Teresa Herrera-Abreu, Andreu Òdena, Mònica Sánchez-Guixé, Marta Capelán, Analía Azaro, Alejandra Bruna, Olga Rodríguez, Marta Guzmán, Judit Grueso, Cristina Viaplana, Javier Hernández, Faye Su, Kui Lin, Robert B. Clarke, Carlos Caldas, Joaquín Arribas, Stefan Michiels, Alicia García-Sanz, Nicholas C. Turner, Aleix Prat, Paolo Nuciforo, Rodrigo Dienstmann, Chandra S. Verma, Nuria Lopez-Bigas, Maurizio Scaltriti, Monica Arnedos, Cristina Saura, Violeta Serra
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
CDK4/6 inhibitor resistance is common in breast cancer. Here, the authors show that p16 overexpression may be linked to reduced efficacy of CDK4/6 inhibition, and show that the combination with PI3K inhibitors may increase anti-tumour effects.
Externí odkaz:
https://doaj.org/article/c3a330e420d34dc992aab0ec2b80986a
Autor:
Marta Palafox, Laia Monserrat, Meritxell Bellet, Guillermo Villacampa, Abel Gonzalez-Perez, Mafalda Oliveira, Fara Brasó-Maristany, Nusaibah Ibrahimi, Srinivasaraghavan Kannan, Leonardo Mina, Maria Teresa Herrera-Abreu, Andreu Òdena, Mònica Sánchez-Guixé, Marta Capelán, Analía Azaro, Alejandra Bruna, Olga Rodríguez, Marta Guzmán, Judit Grueso, Cristina Viaplana, Javier Hernández, Faye Su, Kui Lin, Robert B. Clarke, Carlos Caldas, Joaquín Arribas, Stefan Michiels, Alicia García-Sanz, Nicholas C. Turner, Aleix Prat, Paolo Nuciforo, Rodrigo Dienstmann, Chandra S. Verma, Nuria Lopez-Bigas, Maurizio Scaltriti, Monica Arnedos, Cristina Saura, Violeta Serra
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/c47a0b935486445aafab933f5d652620
Autor:
Marta Castroviejo‐Bermejo, Cristina Cruz, Alba Llop‐Guevara, Sara Gutiérrez‐Enríquez, Mandy Ducy, Yasir Hussein Ibrahim, Albert Gris‐Oliver, Benedetta Pellegrino, Alejandra Bruna, Marta Guzmán, Olga Rodríguez, Judit Grueso, Sandra Bonache, Alejandro Moles‐Fernández, Guillermo Villacampa, Cristina Viaplana, Patricia Gómez, Maria Vidal, Vicente Peg, Xavier Serres‐Créixams, Graham Dellaire, Jacques Simard, Paolo Nuciforo, Isabel T Rubio, Rodrigo Dienstmann, J Carl Barrett, Carlos Caldas, José Baselga, Cristina Saura, Javier Cortés, Olivier Déas, Jos Jonkers, Jean‐Yves Masson, Stefano Cairo, Jean‐Gabriel Judde, Mark J O'Connor, Orland Díez, Judith Balmaña, Violeta Serra
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 12, Pp n/a-n/a (2018)
Abstract Poly(ADP‐ribose) polymerase (PARP) inhibitors (PARPi) are effective in cancers with defective homologous recombination DNA repair (HRR), including BRCA1/2‐related cancers. A test to identify additional HRR‐deficient tumors will help to
Externí odkaz:
https://doaj.org/article/338354bc305a441ba1ed0aea5e8d5f0d
Autor:
Rosaura Esteve-Puig, Rosa Gil, Elena González-Sánchez, Joan Josep Bech-Serra, Judit Grueso, Javier Hernández-Losa, Teresa Moliné, Francesc Canals, Berta Ferrer, Javier Cortés, Boris Bastian, Santiago Ramón Y Cajal, Juan Martín-Caballero, Juana Maria Flores, Ana Vivancos, Vicenç García-Patos, Juan Ángel Recio
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004721 (2014)
Exposure to ultraviolet (UV) radiation from sunlight accounts for 90% of the symptoms of premature skin aging and skin cancer. The tumor suppressor serine-threonine kinase LKB1 is mutated in Peutz-Jeghers syndrome and in a spectrum of epithelial canc
Externí odkaz:
https://doaj.org/article/c3b7bb4d05f143a69b77de7cec7fd350
Autor:
Mariano F. Zacarías-Fluck, Daniel Massó-Vallés, Fabio Giuntini, Íñigo González-Larreategui, Jastrinjan Kaur, Sílvia Casacuberta-Serra, Toni Jauset, Sandra Martínez-Martín, Génesis Martín-Fernández, Erika Serrano del Pozo, Laia Foradada, Judit Grueso, Lara Nonell, Marie-Eve Beaulieu, Jonathan R. Whitfield, Laura Soucek
Publikováno v:
Genes & Development. 37:303-320
MYC's key role in oncogenesis and tumor progression has long been established for most human cancers. In melanoma, its deregulated activity by amplification of 8q24 chromosome or by upstream signaling coming from activating mutations in the RAS/RAF/M
Autor:
José Baselga, Maurizio Scaltriti, Leif W. Ellisen, Javier Cortés, Jordi Rodón, José Pérez, Isabel T. Rubio, Orland Díez, Claudia Aura, Maria Teresa Calvo, Olga Rodríguez, Judit Grueso, Marta Guzmán, Patricia Cozar, Pilar Anton, Aleix Prat, Kristine Torres-Lockhart, Lei He, Violeta Serra, Celina García-García, Yasir H. Ibrahim
PDF file - 301K, Combined PIK3CA siRNA and PARP suppression in TNBC cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1acf8bde04b6f5c7a7aa7db637fb27d9
https://doi.org/10.1158/2159-8290.22528632
https://doi.org/10.1158/2159-8290.22528632
Autor:
José Baselga, Maurizio Scaltriti, Leif W. Ellisen, Javier Cortés, Jordi Rodón, José Pérez, Isabel T. Rubio, Orland Díez, Claudia Aura, Maria Teresa Calvo, Olga Rodríguez, Judit Grueso, Marta Guzmán, Patricia Cozar, Pilar Anton, Aleix Prat, Kristine Torres-Lockhart, Lei He, Violeta Serra, Celina García-García, Yasir H. Ibrahim
PDF file - 3.4MB, Concordance in ER, PR, HER2, and PTEN expression between original patient tumors and the derived tumor grafts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d65ff2ca1cfaff2e7b39f67cb5aafb
https://doi.org/10.1158/2159-8290.22528629
https://doi.org/10.1158/2159-8290.22528629
Autor:
José Baselga, Maurizio Scaltriti, Leif W. Ellisen, Javier Cortés, Jordi Rodón, José Pérez, Isabel T. Rubio, Orland Díez, Claudia Aura, Maria Teresa Calvo, Olga Rodríguez, Judit Grueso, Marta Guzmán, Patricia Cozar, Pilar Anton, Aleix Prat, Kristine Torres-Lockhart, Lei He, Violeta Serra, Celina García-García, Yasir H. Ibrahim
PDF file - 195K, PI3K regulates BRCA expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055b35edad6c46bcbf526ce66f02ef78
https://doi.org/10.1158/2159-8290.22528638.v1
https://doi.org/10.1158/2159-8290.22528638.v1
Autor:
José Baselga, Maurizio Scaltriti, Leif W. Ellisen, Javier Cortés, Jordi Rodón, José Pérez, Isabel T. Rubio, Orland Díez, Claudia Aura, Maria Teresa Calvo, Olga Rodríguez, Judit Grueso, Marta Guzmán, Patricia Cozar, Pilar Anton, Aleix Prat, Kristine Torres-Lockhart, Lei He, Violeta Serra, Celina García-García, Yasir H. Ibrahim
PDF file - 208K, PI3K blockade suppresses BRCA1/2 transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a3c5b4823583643e9d6ea63914ad7d
https://doi.org/10.1158/2159-8290.22528635.v1
https://doi.org/10.1158/2159-8290.22528635.v1
Autor:
José Baselga, Maurizio Scaltriti, Leif W. Ellisen, Javier Cortés, Jordi Rodón, José Pérez, Isabel T. Rubio, Orland Díez, Claudia Aura, Maria Teresa Calvo, Olga Rodríguez, Judit Grueso, Marta Guzmán, Patricia Cozar, Pilar Anton, Aleix Prat, Kristine Torres-Lockhart, Lei He, Violeta Serra, Celina García-García, Yasir H. Ibrahim
PDF file - 162K, Western blot of cell lysates from MDA-MB-468 or PDC44 cells treated with 750nM and 500nM BKM120 respectively for 4 days using the indicated antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c39de330ac8309e344dbf2185f6bcc2
https://doi.org/10.1158/2159-8290.22528626
https://doi.org/10.1158/2159-8290.22528626