IFNγ and IL-12 Restrict Th2 Responses during Helminth/Plasmodium Co-Infection and Promote IFNγ from Th2 Cells

Autor: Alexandre J. Potocnik, Judit Biro, Isobel S. Okoye, Stephanie M. Coomes, Lewis J. Entwistle, Nikolay Nikolov, Jimena Perez-Lloret, Yashaswini Kannan, Jean Langhorne, Victoria S. Pelly, Mark S. Wilson, Stephanie Czieso

Publikováno v: PLoS Pathogens, Vol 11, Iss 7, p e1004994 (2015)
Coomes, S M, Pelly, V S, Kannan, Y, Okoye, I S, Czieso, S, Entwistle, L J, Perez-Lloret, J, Nikolov, N, Potocnik, A J, Biró, J, Langhorne, J & Wilson, M S 2015, ' IFNγ and IL-12 restrict Th2 responses during Helminth/Plasmodium co-infection and promote IFNγ from Th2 cells ', PLoS Pathogens, vol. 11, no. 7, pp. e1004994 . https://doi.org/10.1371/journal.ppat.1004994
PLoS Pathogens

Parasitic helminths establish chronic infections in mammalian hosts. Helminth/Plasmodium co-infections occur frequently in endemic areas. However, it is unclear whether Plasmodium infections compromise anti-helminth immunity, contributing to the chro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0863e8f9d583e2b92b95c003ab672916
http://europepmc.org/articles/PMC4493106?pdf=render

Reduced Generation but Efficient TCRβ-Chain Selection of CD4+8+ Double-Positive Thymocytes in Mice with Compromised CD3 Complex Signaling

Autor: Andreas Würch, Judit Biro, Ingrid Falk, Horst Mossmann, Klaus Eichmann

Publikováno v: The Journal of Immunology. 162:2741-2747

Maturation to the CD4+8+ double-positive (DP) stage of thymocyte development is restricted to cells that have passed TCRβ selection, an important checkpoint at which immature CD4−8− double-negative (DN) cells that express TCRβ polypeptide chain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33e32de5a16ce1891c71d6b39e041475
https://doi.org/10.4049/jimmunol.162.5.2741

Extramedullary Myelopoiesis in Malaria Depends on Mobilization of Myeloid-Restricted Progenitors by IFN-γ Induced Chemokines

Autor: Jean Langhorne, Nikolai N. Belyaev, Alexandre J. Potocnik, Judit Biro

Publikováno v: PLoS Pathogens, Vol 9, Iss 6, p e1003406 (2013)
Belyaev, N N, Biró, J, Langhorne, J & Potocnik, A J 2013, ' Extramedullary Myelopoiesis in Malaria Depends on Mobilization of Myeloid-Restricted Progenitors by IFN-γ Induced Chemokines ', PLoS Pathogens, vol. 9, no. 6, e1003406 . https://doi.org/10.1371/journal.ppat.1003406
PLoS Pathogens

Resolution of a variety of acute bacterial and parasitic infections critically relies on the stimulation of myelopoiesis leading in cases to extramedullary hematopoiesis. Here, we report the isolation of the earliest myeloid-restricted progenitors in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb3e8e7da909ccf3bade1ae357210c06
https://doi.org/10.1371/journal.ppat.1003406

Proliferation kinetics associated with T cell receptor-beta chain selection of fetal murine thymocytes

Autor: Ingrid Falk, Klaus Eichmann, Judit Biro, Hubertus Kohler

Publikováno v: The Journal of Experimental Medicine

After productive rearrangement of a TCR beta chain gene, CD4-8- double negative (DN) thymocytes express TCR beta polypeptide chains on the cell surface together with pre-T alpha and the CD3 complex forming the pre-TCR. Signals transmitted through the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5edfbe60a21696517073b6f110176186
https://pubmed.ncbi.nlm.nih.gov/8976187

Global transcriptional analysis of primitive thymocytes reveals accelerated dynamics of T cell specification in fetal stages

Autor: Alexandre J. Potocnik, Judit Biro, Delmiro Fernandez-Reyes, Nikolai N. Belyaev, Dimitrios Athanasakis

Publikováno v: Immunogenetics

T cell development constitutes a multistage process allowing the dissection of events resulting in cellular commitment and functional specification in a specialized microenvironment. This process is guided by the appropriate expression of regulatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47475e5ce3f0718602554c7f88ef476a