Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Judit, Villén"'
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The dorsolateral prefrontal cortex (DLPFC) has a crucial role in cognitive functioning and negative symptoms in schizophrenia. However, limited information of altered protein networks is available in this region in schizophrenia. We performed a prote
Externí odkaz:
https://doaj.org/article/569da3b3d74842a8ad5bc4d295e06fb4
A novel mistranslating tRNA model in Drosophila melanogaster has diverse, sexually dimorphic effects
Autor:
Joshua R Isaacson, Matthew D Berg, Brendan Charles, Jessica Jagiello, Judit Villén, Christopher J Brandl, Amanda J Moehring
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 12, Iss 5 (2022)
AbstractTransfer RNAs (tRNAs) are the adaptor molecules required for reading the genetic code and producing proteins. Transfer RNA variants can lead to genome-wide mistranslation, the misincorporation of amino acids not specified by the standard gene
Externí odkaz:
https://doaj.org/article/c5092e296afa4677aef185dc2768b57d
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 12, Pp 1-20 (2019)
Abstract Recent developments in proteomics have enabled signaling studies where > 10,000 phosphosites can be routinely identified and quantified. Yet, current analyses are limited in throughput, reproducibility, and robustness, hampering experiments
Externí odkaz:
https://doaj.org/article/769fc20035dd49389b6a18593a0dccab
Autor:
Matthew D Berg, Yanrui Zhu, Bianca Y Ruiz, Raphaël Loll-Krippleber, Joshua Isaacson, Bryan-Joseph San Luis, Julie Genereaux, Charles Boone, Judit Villén, Grant W Brown, Christopher J Brandl
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 10 (2021)
AbstractMistranslation, the misincorporation of an amino acid not specified by the “standard” genetic code, occurs in all organisms. tRNA variants that increase mistranslation arise spontaneously and engineered tRNAs can achieve mistranslation fr
Externí odkaz:
https://doaj.org/article/a5fac9d3f9104a5caee2480e40639006
Autor:
Brian C. Searle, Lindsay K. Pino, Jarrett D. Egertson, Ying S. Ting, Robert T. Lawrence, Brendan X. MacLean, Judit Villén, Michael J. MacCoss
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Data-independent acquisition (DIA)-based proteomics often relies on mass spectrum libraries from data-dependent acquisition experiments. Here, the authors present a method to generate DIA-based chromatogram libraries, enabling DIA-only workflows and
Externí odkaz:
https://doaj.org/article/71667bdd5c6f47bf95aa8da07df2ca8c
Autor:
Francisco Vidal-Domènech, Gemma Riquelme, Raquel Pinacho, Ricard Rodriguez-Mias, América Vera, Alfonso Monje, Isidre Ferrer, Luis F Callado, J Javier Meana, Judit Villén, Belén Ramos
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0230400 (2020)
Alterations in the cortico-cerebellar-thalamic-cortical circuit might underlie the diversity of symptoms in schizophrenia. However, molecular changes in cerebellar neuronal circuits, part of this network, have not yet been fully determined. Using LC-
Externí odkaz:
https://doaj.org/article/ce178c5d51644d6685af9a32c2fdbf40
Autor:
Ian R. Smith, Jimmy K. Eng, Anthony S. Barente, Alexander Hogrebe, Ariadna Llovet, Ricard A. Rodriguez-Mias, Judit Villén
Publikováno v:
Analytical Chemistry. 94:15198-15206
SILAC-based metabolic labeling is a widely adopted proteomics approach that enables quantitative comparisons among a variety of experimental conditions. Despite its quantitative capacity, SILAC experiments analyzed with data dependent acquisition (DD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c59d9c3c6063eee2b624882d029831
https://doi.org/10.1021/acs.analchem.2c01711
https://doi.org/10.1021/acs.analchem.2c01711
Autor:
David Ochoa, Mindaugas Jonikas, Robert T Lawrence, Bachir El Debs, Joel Selkrig, Athanasios Typas, Judit Villén, Silvia DM Santos, Pedro Beltrao
Publikováno v:
Molecular Systems Biology, Vol 12, Iss 12, Pp 1-14 (2016)
Abstract The coordinated regulation of protein kinases is a rapid mechanism that integrates diverse cues and swiftly determines appropriate cellular responses. However, our understanding of cellular decision‐making has been limited by the small num
Externí odkaz:
https://doaj.org/article/09d2095df86741d5b9f0ad18fe144ab0
Publikováno v:
bioRxiv
Phosphotyrosine (pY) enrichment is critical for expanding fundamental and clinical understanding of cellular signaling by mass spectrometry-based proteomics. However, current pY enrichment methods exhibit a high cost per sample and limited reproducib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55f899d0ec3bee02d836903806c9d8a2
https://europepmc.org/articles/PMC9881991/
https://europepmc.org/articles/PMC9881991/
Autor:
Robert T. Lawrence, Elizabeth M. Perez, Daniel Hernández, Chris P. Miller, Kelsey M. Haas, Hanna Y. Irie, Su-In Lee, C. Anthony Blau, Judit Villén
Publikováno v:
Cell Reports, Vol 11, Iss 4, Pp 630-644 (2015)
Triple-negative breast cancer is a heterogeneous disease characterized by poor clinical outcomes and a shortage of targeted treatment options. To discover molecular features of triple-negative breast cancer, we performed quantitative proteomics analy
Externí odkaz:
https://doaj.org/article/b77b8a1f878c45758aa622ed53bbe73c