Active Aβ immunotherapy CAD106 in Alzheimer's disease

Autor: Philip Scheltens, Raquel Sánchez-Valle, Giovanni Marotta, Ana Graf, R. Paul Maguire, Rik Vandenberghe, Judit Sovago, Marie Emmanuelle Riviere, Angelika Caputo, Martin R. Farlow, J. Michael Ryan

Publikováno v: Alzheimer's and Dementia: Translational Research and Clinical Interventions, 3(1), 10-22. Elsevier Inc.
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Vandenberghe, R, Riviere, M-E, Caputo, A, Sovago, J, Maguire, R P, Farlow, M, Marotta, G, Sanchez-Valle, R, Scheltens, P, Ryan, J M & Graf, A 2017, ' Active Aβ immunotherapy CAD106 in Alzheimer's disease : A phase 2b study ', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 3, no. 1, pp. 10-22 . https://doi.org/10.1016/j.trci.2016.12.003

INTRODUCTION: This randomized, double-blind, placebo-controlled, 90-week study assessed safety, tolerability, and immunogenicity of CAD106 with/without adjuvant in patients with mild Alzheimer's disease.METHODS: One hundred twenty-one patients receiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d279ff8b2d972c071c22f7818e64b8
https://doi.org/10.1016/j.trci.2016.12.003

Assessment of Cognitive Outcome Measures in Teenagers with 15q13.3 Microdeletion Syndrome

Autor: John Harrison, Christian P. Schaaf, Baltazar Gomez-Mancilla, May Ali, Judit Sovago, Emeline Crutcher

Publikováno v: Crutcher, E, Ali, M, Harrison, J, Sovago, J, Gomez-Mancilla, B & Schaaf, C P 2016, ' Assessment of Cognitive Outcome Measures in Teenagers with 15q13.3 Microdeletion Syndrome ', Journal of Autism and Developmental Disorders, vol. 46, no. 4, pp. 1455-1463 . https://doi.org/10.1007/s10803-015-2694-0
Journal of Autism and Developmental Disorders, 46(4), 1455-1463. Springer New York

15q13.3 microdeletion syndrome causes a spectrum of cognitive disorders, including intellectual disability and autism. We aimed to determine if any or all of three cognitive testing systems (the KiTAP, CogState, and Stanford–Binet) are suitable for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::941ed074d1cb2b4d50c775166d8c41dd
https://doi.org/10.1007/s10803-015-2694-0

Increased Metabotropic Glutamate Receptor Subtype 5 Availability in Human Brain After One Night Without Sleep

Autor: Valérie Bachmann, Judit Sovago, Katharina Hefti, Baltazar Gomez-Mancilla, Milan Scheidegger, Erich Seifritz, Sebastian C. Holst, Simon M. Ametamey, Thomas Berthold, Hans-Peter Landolt, Alfred Buck

Publikováno v: BIOLOGICAL PSYCHIATRY

Sleep deprivation (wake therapy) provides rapid clinical relief in many patients with major depressive disorder (MDD). Changes in glutamatergic neurotransmission may contribute to the antidepressant response, yet the exact underlying mechanisms are u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce86fff9e59f17031954a68d3c8256f2
https://doi.org/10.1016/j.biopsych.2012.07.030

Reduced Metabotropic Glutamate Receptor 5 Density in Major Depression Determined by [11C]ABP688 PET and Postmortem Study

Autor: Craig A. Stockmeier, Alfred Buck, Anteneh M. Feyissa, Judit Sovago, Simon M. Ametamey, Alexandra Deschwanden, Gregor Hasler, Yves Auberson, Anass Johayem, Valerie Treyer, Cyrill Burger, Beata Karolewicz

Publikováno v: American Journal of Psychiatry. 168:727-734

Objective:Clinical and preclinical evidence suggests a hyperactive glutamatergic system in clinical depression. Recently, the metabotropic glutamate receptor 5 (mGluR5) has been proposed as an attractive target for novel therapeutic approaches to dep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0852bb7f7c0bb49d7c2e824c26dbb33f
https://doi.org/10.1176/appi.ajp.2011.09111607

Synthesis and Positron Emission Tomography Evaluation of Three Norepinephrine Transporter Radioligands: [C-11]Desipramine, [C-11]Talopram and [C-11]Talsupram

Autor: Balázs Gulyás, Magnus Schou, Christer Halldin, Judit Sovago, Klaus Peter Bogeso, Lars Farde, Victor W. Pike

Publikováno v: Molecular Imaging and Biology. 8:1-8

Desipramine (DMI), talopram and talsupram, three of the most potent norepinephrine transporter (NET) inhibitors reported to date, were radiolabeled in high yields and at high specific radioactivity (58-75 GBq/micromol) by the methylation of nor-precu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be6fbfd0c8ed89b380a2dc51fc815ed
https://doi.org/10.1007/s11307-005-0027-y