Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Judicael Fazavana"'
Autor:
Clive Drakeford, Sonia Aguila, Fiona Roche, Karsten Hokamp, Judicael Fazavana, Mariana P. Cervantes, Annie M. Curtis, Heike C. Hawerkamp, Sukhraj Pal Singh Dhami, Hugo Charles-Messance, Emer E. Hackett, Alain Chion, Soracha Ward, Azaz Ahmad, Ingmar Schoen, Eamon Breen, Joe Keane, Ross Murphy, Roger J. S. Preston, Jamie M. O’Sullivan, Frederick J. Sheedy, Padraic Fallon, James S. O’Donnell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
von Willebrand factor (VWF) plays a critical role in primary hemostasis following vascular injury by tethering platelets to exposed collagen. Here, VWF binding to macrophages is shown to trigger NF-κB activation and induce pro-inflammatory responses
Externí odkaz:
https://doaj.org/article/0abf998c232d43bcab767dde021ae471
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 1, Pp n/a-n/a (2022)
Abstract Cerebral malaria (CM) continues to be associated with major morbidity and mortality, particularly in children aged
Externí odkaz:
https://doaj.org/article/6dd837955b124447ade3e9b00f0b8eb5
Autor:
Soracha E. Ward, Jamie M. O’Sullivan, Alan B. Moran, Daniel I. R. Spencer, Richard A. Gardner, Jyotika Sharma, Judicael Fazavana, Marco Monopoli, Thomas A.J. McKinnon, Alain Chion, Sandra Haberichter, James S. O’Donnell
Publikováno v:
Haematologica, Vol 107, Iss 3 (2021)
Terminal sialylation determines the plasma half-life of von Willebrand factor (VWF). A role for macrophage galactose lectin (MGL) in regulating hyposialylated VWF clearance has recently been proposed. In this study, we showed that MGL influences phys
Externí odkaz:
https://doaj.org/article/df84523d82df4f9a98f0024a5a9002a7
Autor:
Einas Elsheikh, Michelle Lavin, Lilian Antunes Heck, Niamh Larkin, Brendan Mullaney, Dearbhla Doherty, Megan Kennedy, Catriona Keenan, Thomas Guest, Brian O'Mahony, Judicael Fazavana, Padraic G. Fallon, Roger J.S. Preston, John Gormley, Kevin Ryan, Niamh M. O'Connell, Evelyn Singleton, Mary Byrne, Mark McGowan, Sheila Roche, Mairead Doyle, Maeve P. Crowley, Susan I. O'Shea, Birgit M. Reipert, Jill M. Johnsen, Steven W. Pipe, Jorge Di Paola, Peter L. Turecek, James S. O'Donnell
Publikováno v:
Journal of Thrombosis and Haemostasis. 21:1123-1134
Autor:
Helen Fogarty, Soracha E. Ward, Liam Townsend, Ellie Karampini, Stephanie Elliott, Niall Conlon, Jean Dunne, Rachel Kiersey, Aifric Naughton, Mary Gardiner, Mary Byrne, Colm Bergin, Jamie M. O'Sullivan, Ignacio Martin-Loeches, Parthiban Nadarajan, Ciaran Bannan, Patrick W. Mallon, Gerard F. Curley, Roger J.S. Preston, Aisling M. Rehill, Ross I. Baker, Cliona Ni Cheallaigh, James S. O'Donnell, Niamh O’Connell, Kevin Ryan, Dermot Kenny, Judicael Fazavana
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:2429-2438
Prolonged recovery is common after acute SARS-CoV-2 infection; however, the pathophysiological mechanisms underpinning Long COVID syndrome remain unknown. VWF/ADAMTS-13 imbalance, dysregulated angiogenesis, and immunothrombosis are hallmarks of acute
Autor:
Helen Fogarty, Liam Townsend, Hannah Morrin, Azaz Ahmad, Claire Comerford, Ellie Karampini, Hanna Englert, Mary Byrne, Colm Bergin, Jamie M. O’Sullivan, Ignacio Martin‐Loeches, Parthiban Nadarajan, Ciaran Bannan, Patrick W. Mallon, Gerard F. Curley, Roger J.S. Preston, Aisling M. Rehill, Dennis McGonagle, Cliona Ni Cheallaigh, Ross I. Baker, Thomas Renné, Soracha E. Ward, James S. O’Donnell, Niamh O’Connell, Kevin Ryan, Dermot Kenny, Judicael Fazavana
Publikováno v:
Journal of Thrombosis and Haemostasis
Background Persistent symptoms including breathlessness, fatigue, and decreased exercise tolerance have been reported in patients after acute SARS-CoV-2 infection. The biological mechanisms underlying this “long COVID” syndrome remain unknown. Ho
Autor:
Marco P. Monopoli, Sandra L. Haberichter, Alan B. Moran, Thomas A. J. McKinnon, Richard A. Gardner, Daniel I. R. Spencer, Judicael Fazavana, Jyotika Sharma, Jamie M. O’Sullivan, Soracha E. Ward, Alain Chion, James S. O’Donnell
Terminal sialylation determines the plasma half-life of von Willebrand factor (VWF). A role for macrophage galactose lectin (MGL) in regulating hyposialylated VWF clearance has recently been proposed. In this study, we showed that MGL influences phys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a6c4cc6b366b91dd9071cc283fcf688
http://hdl.handle.net/10044/1/96696
http://hdl.handle.net/10044/1/96696
Autor:
Clive Drakeford, Sonia Aguila, Fiona Roche, Karsten Hokamp, Judicael Fazavana, Mariana P. Cervantes, Annie M. Curtis, Heike C. Hawerkamp, Sukhraj Pal Singh Dhami, Hugo Charles-Messance, Emer E. Hackett, Alain Chion, Soracha Ward, Azaz Ahmad, Ingmar Schoen, Eamon Breen, Joe Keane, Ross Murphy, Roger J. S. Preston, Jamie M. O’Sullivan, Frederick J. Sheedy, Padraic Fallon, James S. O’Donnell
Publikováno v:
Nature communications. 13(1)
The plasma multimeric glycoprotein von Willebrand factor (VWF) plays a critical role in primary hemostasis by tethering platelets to exposed collagen at sites of vascular injury. Recent studies have identified additional biological roles for VWF, and
Autor:
Chuenlei Parng, James S. O’Donnell, Matthew Allister Lambert, Orla Cunningham, Judicael Fazavana, Teresa M. Brophy, Justin Cohen, Alain Chion, Niamh M. Cooke, Jamie M. O’Sullivan, Virginie Terraube, Debra D. Pittman
Publikováno v:
J Thromb Haemost
Background Previous studies have demonstrated that the A1A2A3 domains of von Willebrand factor (VWF) play a key role in regulating macrophage-mediated clearance in vivo. In particular, the A1-domain has been shown to modulate interaction with macroph
Autor:
François Saller, Yasmine Bourti, Elsa P. Bianchini, Judicael Fazavana, Delphine Borgel, Dominique Lasne, Marine Armand
Publikováno v:
Thrombosis and Haemostasis. 116:452-460
SummaryIn the absence of specific antidote to fondaparinux, two modified forms of antithrombin (AT), one recombinant inactive (ri-AT) and the other chemically inactivated (chi-AT), were designed to antagonise AT-mediated anticoagulants, e. g. heparin