Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Judeth J. Klansek"'
Autor:
Judeth J. Klansek, Laura Liscum
Publikováno v:
Current Opinion in Lipidology. 9:131-135
Niemann-Pick type C (NPC) is an autosomal recessive lysosomal storage disease. Fibroblasts from individuals with Niemann-Pick type C exhibit defective intracellular cholesterol transport. Linkage analysis has led to the recent cloning of the NPC1 gen
Publikováno v:
Journal of Biological Chemistry. 271:4923-4929
Using the Chinese hamster ovary cell line, 25-RA, we have demonstrated that lipoprotein-derived cholesterol and endogenously synthesized cholesterol are selectively differentiated with respect to their cellular locations. These cells lack sterol-medi