HSP70 and their co-chaperones in the human malaria parasite P. falciparum and their potential as drug targets

Autor: Julian Barth, Tim Schach, Jude M. Przyborski

Publikováno v: Frontiers in Molecular Biosciences, Vol 9 (2022)

As part of their life-cycle, malaria parasites undergo rapid cell multiplication and division, with one parasite giving rise to over 20 new parasites within the course of 48 h. To support this, the parasite has an extremely high metabolic rate and le

Externí odkaz: https://doaj.org/article/037fe3037bb84b988283d8fc2524e96f

Prokaryotic ancestry and gene fusion of a dual localized peroxiredoxin in malaria parasites

Autor: Carine F. Djuika, Jaime Huerta-Cepas, Jude M. Przyborski, Sophia Deil, Cecilia P. Sanchez, Tobias Doerks, Peer Bork, Michael Lanzer, Marcel Deponte

Publikováno v: Microbial Cell, Vol 2, Iss 1, Pp 5-13 (2015)

Horizontal gene transfer has emerged as a crucial driving force for the evolution of eukaryotes. This also includes Plasmodium falciparum and related economically and clinically relevant apicomplexan parasites, whose rather small genomes have been sh

Externí odkaz: https://doaj.org/article/c9bdf538bcf34ecfb4178e6c6e0ae2df

A nuclear protein, PfMORC confers melatonin dependent synchrony of the human malaria parasite P. falciparum in the asexual stage

Autor: Célia R.S. Garcia, Maneesh Kumar Singh, Fahyme Costa, Bárbara K M Dias, Giulliana Tessarin-Almeida, Jude M. Przyborski, Pedro Scarpellli Pereira

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Scientific Reports

The host hormone melatonin is known to modulate the asexual cell-cycle of the human malaria parasite Plasmodium falciparum and the kinase PfPK7 is fundamental in the downstream signaling pathways. The nuclear protein PfMORC displays a histidine kinas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::650d496e15ea8dc00475ee58207d7e4d
https://doaj.org/article/56eac78196474ce4a12acb089a0710f1

Structure and function of redox-sensitive superfolder green fluorescent protein variant

Autor: Kim C. Heimsch, Christoph G.W. Gertzen, Anna Katharina Schuh, Thomas Nietzel, Stefan Rahlfs, Jude M. Przyborski, Holger Gohlke, Markus Schwarzländer, Katja Becker, Karin Fritz-Wolf

Publikováno v: Antioxidants and Redox Signaling
Antioxidants & redox signaling 37(1-3), ars.2021.0234 (2022). doi:10.1089/ars.2021.0234

Aims: Genetically encoded GFP-based redox biosensors are widely used to monitor specific and dynamic redox processes in living cells. Over the last years, various biosensors for a variety of applications were engineered and enhanced to match the orga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf112322073aa6f635a66e87864de2de
https://hdl.handle.net/21.11116/0000-000A-CE00-E21.11116/0000-000A-CE01-D21.11116/0000-000A-CE02-C21.11116/0000-000A-CE03-B21.11116/0000-000A-CE04-A21.11116/0000-000A-2E33-A21.11116/0000-000A-CE05-921.11116/0000-000A-CDFC-421.11116/0000-000A-CDFD-321.11116/0000-000A-CDFE-221.11116/0000-000A-CDFF-1

Characterization of Plasmodium falciparum macrophage migration inhibitory factor homologue and its cysteine deficient mutants

Autor: Susanne Schipper, Jürgen Bernhagen, Jude M. Przyborski, Stefan Rahlfs, Eric Springer, Katja Becker, Julia Hahn, Priscila Bourilhon

Publikováno v: Parasitology international. 87

Plasmodium falciparum macrophage migration inhibitory factor (PfMIF) is a homologue of the multifunctional human host cytokine MIF (HsMIF). Upon schizont rupture it is released into the human blood stream where it acts as a virulence factor, modulati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b54408fa5fe72a1128e94ed173baa23
https://pubmed.ncbi.nlm.nih.gov/34785370