Whole-body PET imaging in humans shows that 11C-PS13 is selective for cyclooxygenase-1 and can measure the in vivo potency of nonsteroidal anti-inflammatory drugs.

Autor: Min-Jeong Kim, Juarez Anaya, Fernanda, Manly, Lester S., Jae-Hoon Lee, Jinsoo Hong, Shrestha, Stal, Telu, Sanjay, Henry, Katharine, Montero Santamaria, Jose A., Liow, Jeih-San, Zanotti-Fregonara, Paolo, Shetty, H. Umesha, Zoghbi, Sami S., Pike, Victor W., Innis, Robert B.

Publikováno v: Journal of Nuclear Medicine; Sep2022, Vol. 63 Issue 9, p1-26, 44p

First-in-human evaluation of [ ¹¹ C]PS13, a novel PET radioligand, to quantify cyclooxygenase-1 in the brain.

Autor: Kim MJ; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA. min-jeong.kim@nih.gov., Lee JH; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA.; Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea., Juarez Anaya F; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Hong J; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Miller W; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Telu S; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Singh P; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Cortes MY; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Henry K; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Tye GL; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Frankland MP; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Montero Santamaria JA; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Liow JS; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Zoghbi SS; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Fujita M; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Pike VW; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA., Innis RB; Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Bldg. 10, Rm B1D43, Bethesda, MD, 20892-1026, USA.

Publikováno v: European journal of nuclear medicine and molecular imaging [Eur J Nucl Med Mol Imaging] 2020 Dec; Vol. 47 (13), pp. 3143-3151. Date of Electronic Publication: 2020 May 12.