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Akademický článek

DTL promotes the growth and migration of melanoma cells through the ERK/E2F1/BUB1 axis

Autor: Xiuyun Xuan, Juanmei Cao, Li Chen, Jing Zhang, Yue Qian, Changzheng Huang

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)

Abstract Melanoma is the most dangerous form of skin cancer. Hence, a better understanding of molecular mechanisms in melanoma pathogenesis is urgently needed, which provides a new insight into the therapy of melanoma. DTL gene is screened out in mel

Externí odkaz: https://doaj.org/article/f56dfc8c86f04dc5a0139c4b5d53229f

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Akademický článek

The role of ferroptosis in the treatment and prognosis of malignant melanoma

Autor: Yuqing WANG, Fangqi CHEN, Juanmei CAO, Ting WU, Yan LIANG, Yifan JIN, Jinshan ZHAN, Changzheng HUANG

Publikováno v: Pifu-xingbing zhenliaoxue zazhi, Vol 30, Iss 3, Pp 279-283 (2023)

Malignant melanoma (MM) is a highly malignant tumor of melanocytes, with increasing mortality rate and incidence rate in recent years. Although the treatments with targeted therapies and immune checkpoint inhibitors have significantly improved surviv

Externí odkaz: https://doaj.org/article/c2d4549f4dbc4def93487f595e1876a7

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Akademický článek

Identification and characterization of bone/cartilage-associated signatures in common fibrotic skin diseases

Autor: Ting Wu, Yifan Jin, Fangqi Chen, Xiuyun Xuan, Juanmei Cao, Yan Liang, Yuqing Wang, Jinshan Zhan, Mengjie Zhao, Changzheng Huang

Publikováno v: Frontiers in Genetics, Vol 14 (2023)

Background: Fibrotic skin diseases are characterized by excessive accumulation of the extracellular matrix (ECM) and activation of fibroblasts, leading to a global healthcare burden. However, effective treatments of fibrotic skin diseases remain limi

Externí odkaz: https://doaj.org/article/1f60eeaf204a47b0a0b65559cce72195

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Akademický článek

Interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy

Autor: Xiuyun Xuan, Lin Zhang, Chunxia Tian, Ting Wu, Haihua Ye, Juanmei Cao, Fangqi Chen, Yan Liang, Huilan Yang, Changzheng Huang

Publikováno v: Cell & Bioscience, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Interleukin-22 (IL-22), a member of the IL-10 family of cytokines, is produced by a number of immune cells involved in the immune microenvironment of the body. IL-22 plays its pivotal roles by binding to the IL-22 receptor complex (IL-22R) a

Externí odkaz: https://doaj.org/article/c50debe344004d12b2a1a7e969a3f94e

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