Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Juanma Ramírez"'
Autor:
Uxue Balantzategi, Adhara Gaminde-Blasco, Lierni Aizpurua, Juanma Ramírez, Ugo Mayor, Asier Ruiz, Carlos Matute, José Luis Zugaza, Elena Alberdi
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S364- (2023)
Externí odkaz:
https://doaj.org/article/e298065dcca948c5977a904a3edc8d46
Autor:
Luis O. Romero, Rebeca Caires, A. Kaitlyn Victor, Juanma Ramirez, Francisco J. Sierra-Valdez, Patrick Walsh, Vincent Truong, Jungsoo Lee, Ugo Mayor, Lawrence T. Reiter, Valeria Vásquez, Julio F. Cordero-Morales
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Angelman syndrome (AS) is a neurogenetic disorder. Here, the authors found that PIEZO2 activity is reduced in sensory neurons from a mouse model of AS and used a linoleic acid-enriched diet to enhance PIEZO2 function and ameliorate AS-associated gait
Externí odkaz:
https://doaj.org/article/664f09f3735d4266a19b95c85b38e994
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
E3 ubiquitin ligases are the ultimate enzymes involved in the transfer of ubiquitin to substrate proteins, a process that determines the fate of the modified protein. Numerous diseases are caused by defects in the ubiquitin-proteasome machinery, incl
Externí odkaz:
https://doaj.org/article/952b40603ecd4c8d9e0f2d1d39f2b7eb
Autor:
Nora Urraca, Kevin Hope, A. Kaitlyn Victor, T. Grant Belgard, Rawaha Memon, Sarita Goorha, Colleen Valdez, Quynh T. Tran, Silvia Sanchez, Juanma Ramirez, Martin Donaldson, Dave Bridges, Lawrence T. Reiter
Publikováno v:
Molecular Autism, Vol 9, Iss 1, Pp 1-16 (2018)
Abstract Background The inability to analyze gene expression in living neurons from Angelman (AS) and Duplication 15q (Dup15q) syndrome subjects has limited our understanding of these disorders at the molecular level. Method Here, we use dental pulp
Externí odkaz:
https://doaj.org/article/a05b1471620e4455bbdd728d00816017
Autor:
Aitor Martinez, Benoit Lectez, Juanma Ramirez, Oliver Popp, James D. Sutherland, Sylvie Urbé, Gunnar Dittmar, Michael J. Clague, Ugo Mayor
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-19 (2017)
Abstract Background Parkin (PARK2) is an E3 ubiquitin ligase that is commonly mutated in Familial Parkinson’s Disease (PD). In cell culture models, Parkin is recruited to acutely depolarised mitochondria by PINK1. PINK1 activates Parkin activity le
Externí odkaz:
https://doaj.org/article/27faf3193c6f4049a8c444845e938b87
Autor:
Nagore Elu, Nerea Osinalde, Javier Beaskoetxea, Juanma Ramirez, Benoit Lectez, Kerman Aloria, Jose Antonio Rodriguez, Jesus M. Arizmendi, Ugo Mayor
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
The ubiquitin E3 ligase UBE3A has been widely reported to interact with the proteasome, but it is still unclear how this enzyme regulates by ubiquitination the different proteasomal subunits. The proteasome receptor DDI1 has been identified both in D
Externí odkaz:
https://doaj.org/article/283efb25a4ec49ab9039f13971d3323a
Autor:
Juanma Ramirez, Gorka Prieto, Anne Olazabal-Herrero, Eva Borràs, Elvira Fernandez-Vigo, Unai Alduntzin, Nerea Osinalde, Javier Beaskoetxea, Benoit Lectez, Kerman Aloria, Jose Antonio Rodriguez, Alberto Paradela, Eduard Sabidó, Javier Muñoz, Fernando Corrales, Jesus M. Arizmendi, Ugo Mayor
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4851 (2021)
The human genome contains nearly 100 deubiquitinating enzymes (DUBs) responsible for removing ubiquitin moieties from a large variety of substrates. Which DUBs are responsible for targeting which substrates remain mostly unknown. Here we implement th
Externí odkaz:
https://doaj.org/article/044162302ae649c0a1f2aaae54ea49f9
Autor:
Juanma Ramirez, Aitor Martinez, Benoit Lectez, So Young Lee, Maribel Franco, Rosa Barrio, Gunnar Dittmar, Ugo Mayor
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139083 (2015)
Ubiquitination is known to regulate physiological neuronal functions as well as to be involved in a number of neuronal diseases. Several ubiquitin proteomic approaches have been developed during the last decade but, as they have been mostly applied t
Externí odkaz:
https://doaj.org/article/3f2d15f296094b05a6b3380625e2224a