Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Juanita Shaffer"'
Autor:
Megan Sykes, Meredith Chittenden, Akira Shimizu, Yasuhiro Fudaba, Takashi Onoe, Roderick T. Bronson, Juanita Shaffer
Publikováno v:
The Journal of Immunology. 181:7649-7659
Porcine thymus grafts support robust murine and human thymopoiesis, generating a diverse T cell repertoire that is deleted of donor and host-reactive cells, achieving specific xenograft tolerance. Positive selection is mediated exclusively by the xen
Autor:
Bimalangshu R. Dey, Eyal C. Attar, Andrew Yee, Steven L. McAfee, Nancy J. Tarbell, Megan Sykes, David H. Sachs, David T. Ting, Juanita Shaffer, Frederic I. Preffer, Christine Colby, Martin Caron, Thomas R. Spitzer, Susan L. Saidman, Karen K. Ballen, Karen A. Power
Publikováno v:
Bone Marrow Transplantation. 40:19-27
This is the first study to examine the outcomes in 54 patients with hematologic malignancies who received an HLA-matched related donor bone marrow (BM, n = 42) or GCSF-mobilized peripheral blood stem cells (PBSC, n = 12) following identical nonmyeloa
Autor:
Francis L. Delmonico, Megan Sykes, T. Bonnefoix, Juanita Shaffer, David H. Sachs, Thomas R. Spitzer, Bimalangshu R. Dey, Cosimi Ab, Nina Tolkoff-Rubin, Thomas Fehr, Robert B. Colvin, Karen A. Power, Susan L. Saidman, Kristin Kattleman, Yasuhiro Fudaba, Frederic I. Preffer, Tatsuo Kawai, Steven L. McAfee, A. Kraus
Publikováno v:
American Journal of Transplantation. 6:2121-2133
Six patients with renal failure due to multiple myeloma (MM) received simultaneous kidney and bone marrow transplantation (BMT) from HLA-identical sibling donors following nonmyeloablative conditioning, including cyclophosphamide (CP), peritransplant
Publikováno v:
Blood. 103:4336-4343
Anti-CD154 (CD40L) monoclonal antibody (mAb) plus bone marrow transplantation (BMT) in mice receiving CD8 cell-depleting mAb leads to long-term mixed hematopoietic chimerism and systemic donor-specific tolerance through peripheral and central deletio
Publikováno v:
Blood. 103:1949-1954
Long-term multilineage chimerism is achieved in CD45 congenic mice receiving high bone marrow doses with or without mediastinal irradiation (MI). Increased donor chimerism results in MI-treated compared with nonirradiated animals, suggesting that MI
Autor:
Susan L. Saidman, Thomas R. Spitzer, Bimalanghu Dey, Frederic I. Preffer, David Dombkowski, Christian Koenecke, Megan Sykes, Steven L. McAfee, Juanita Shaffer, Stephen I. Alexander
Publikováno v:
Experimental Hematology. 31:911-923
Objective Natural killer (NK) cells kill allogeneic cells that lack a class I MHC ligand for clonally distributed killer inhibitory receptors (KIR). Following HLA-mismatched hematopoietic cell transplantation (HCT), donor NK cells might mediate graft
Autor:
Megan Sykes, Bimalangsu Dey, Han Chong Toh, Thomas R. Spitzer, Robert Sackstein, Annette B. Kraus, Steven L. McAfee, Juanita Shaffer, Richard George, David Dombkowski, Susan L. Saidman, Frederic I. Preffer, Christine Colby
Publikováno v:
Experimental Hematology. 31:609-621
We developed a nonmyeloablative conditioning regimen for allogeneic bone marrow transplantation (BMT) followed by donor lymphocyte infusions (DLI) for treatment of chemotherapy refractory malignancies. Although the majority of patients who receive th
Autor:
Juanita Shaffer, Megan Sykes, David H. Sachs, Steven L. McAfee, Howard Grossberg, Bimalangshu R. Dey, Thomas R. Spitzer, Stephen I. Alexander, J Hope, Christine Colby, Frederic I. Preffer
Publikováno v:
Transplantation. 75:1748-1751
We initiated a clinical trial of nonmyeloablative haploidentical stem-cell transplantation (SCT) using MEDI-507, an immunoglobulin-G1 monoclonal anti-CD2 antibody. The trial was based on a preclinical major histocompatibility complex-mismatched bone
Publikováno v:
American Journal of Transplantation. 1:339-349
We have previously shown that high levels of multiline-age mixed hematopoietic chimerism and systemic T-cell tolerance can be achieved in mice without myeloablation through the use of anti-CD40L and costimulatory blockade alone (plus CTLA4Ig) or with
Publikováno v:
The Journal of Immunology. 166:2970-2981
Costimulatory blockade can be used to promote allogeneic marrow engraftment and tolerance induction, but on its own is not 100% reliable. We sought to determine whether one or the other of the CD4 or CD8 T cell subsets of the recipient was primarily