Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Juanita M. Smietana"'
Autor:
Jeremy Bradbeer, Margaret E. Sorenson, Jerry L. Adams, Marie Chabot-Fletcher, John J. Breton, Donald E. Griswold, Timothy Francis Gallagher, L. M. Hillegass, Alison M. Badger, Ravi Shanker Garigipati, Juanita M. Smietana, Peter L. Sheldrake, John C. Lee, Jeffrey T. Laydon, Jeffrey C. Boehm
Publikováno v:
Journal of Medicinal Chemistry. 39:3929-3937
A series of 1-alkyl- or -aryl-4-aryl-5-pyridinylimidazoles (A) were prepared and tested for their ability to bind to a recently discovered protein kinase termed CSBP and to inhibit lipopolysaccharide (LPS)-stimulated TNF production in mice. The kinas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7978f78e66ede571626a991f613937da
https://doi.org/10.1021/jm960415o
https://doi.org/10.1021/jm960415o
Autor:
Paul Elliot Bender, Susan M. Fier-Thompson, Timothy Francis Gallagher, Ravi Shanker Garigipati, John J. Breton, Jeffrey T. Laydon, John C. Lee, Don E. Griswold, Juanita M. Smietana, Jerry L. Adams, Marie Chabot-Fletcher, Dennis Lee, Margaret E. Sorenson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:1171-1176
As part of an effort to define the pharmacophore and discover the mechanism by which the antiinflammatory dual cyclooxygenase / 5-lipoxygenase inhibitors SK&F 86002 and SK&F 105809 inhibit IL-1 biosynthesis, a series of substituted 2,4,5-triarylimida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf530aefbba7fd52abcababc28d8a55e
https://doi.org/10.1016/0960-894x(95)00189-z
https://doi.org/10.1016/0960-894x(95)00189-z
Autor:
Nicholas A. Kartsonis, John R. Perfect, Robert J. Lupinacci, Juanita M Smietana, Arnaldo Lopes Colombo, Carole A. Sable, Luis Thompson-Moya, Robert F. Betts, Coleman Rotstein, Jorge Mora-Duarte
Publikováno v:
The New England journal of medicine. 347(25)
Caspofungin is an echinocandin agent with fungicidal activity against candida species. We performed a double-blind trial to compare caspofungin with amphotericin B deoxycholate for the primary treatment of invasive candidiasis.We enrolled patients wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61466906dfaf55189ad4fc283523b9d
https://pubmed.ncbi.nlm.nih.gov/12841719
https://pubmed.ncbi.nlm.nih.gov/12841719
Autor:
Robert J. Lupinacci, L. Miguel Noriega, Nicholas A. Kartsonis, Eduardo G. Arathoon, Eduardo Gotuzzo, Carole A. Sable, Juanita M Smietana, Alvaro Villanueva, Mark J. DiNubile
Publikováno v:
The American journal of medicine. 113(4)
Background Candida esophagitis remains an important cause of morbidity in patients with advanced human immunodeficiency virus (HIV) infection. Fluconazole is widely regarded as the treatment of choice for this condition. Methods The efficacy and safe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c31366597e6bbbaeeac738e9b8b99a
https://pubmed.ncbi.nlm.nih.gov/12361815
https://pubmed.ncbi.nlm.nih.gov/12361815
Autor:
Jeffrey T. Laydon, Glenn A. Hofmann, Jeffrey C. Boehm, Jeffrey W. Abt, Margaret E. Soreson, Susan M. Fier-Thompson, Juanita M. Smietana, Peter R. Young, Timothy Francis Gallagher, John C. Lee, Mary Jane Blumenthal, Arnold J. Krog, Ralph Hall, Dennis Lee, Paul Elliot Bender, Karl F. Erhard, Ravi Shanker Garigipati, Jerry L. Adams, Peter C. McDonnell, George Leslie Seibel, Shouki Kassis, Sanjay Kumar, Peter L. Sheldrake
Publikováno v:
Bioorganicmedicinal chemistry. 5(1)
Members of three classes of pyridinylimidazoles bind with varying affinities to CSBP (p38) kinase which is a member of a stress-induced signal transduction pathway. Based upon SAR and protein homology modeling, the pharmacophore and three potential m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e122df6ffe903523b617fc84550c0c
https://pubmed.ncbi.nlm.nih.gov/9043657
https://pubmed.ncbi.nlm.nih.gov/9043657