Disentangling the molecular mechanisms underlying the retrieval and extinction of morphine withdrawal-associated memories in the basolateral amygdala and dentate gyrus

Autor: Aurelio Franco-García, Francisco José Fernández-Gómez, Victoria Gómez-Murcia, Juana M. Hidalgo, Cristina Núñez, M. Victoria Milanés

Despite their indisputable efficacy for pain management, opiates prescription remains highly controversial due to their elevated addictive potential. Relapse in drug use is one of the principal problems for addiction treatment, being drug-associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4967ee2efb465cf903eb2f8bdb35e55d
https://doi.org/10.1101/2022.02.05.479241

Distinct Regulation of Dopamine D3 Receptor in the Basolateral Amygdala and Dentate Gyrus during the Reinstatement of Cocaine CPP Induced by Drug Priming and Social Stress

Autor: Rocío Guerrero-Bautista, M. Victoria Milanés, Cristina Núñez, Juana M. Hidalgo, Francisco José Fernández-Gómez, Aurelio Franco-García, Bruno Ribeiro Do Couto

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 6
DIGITUM. Depósito Digital Institucional de la Universidad de Murcia
instname
DIGITUM: Depósito Digital Institucional de la Universidad de Murcia
Universidad de Murcia
International Journal of Molecular Sciences, Vol 22, Iss 3100, p 3100 (2021)

Relapse in the seeking and intake of cocaine is one of the main challenges when treating its addiction. Among the triggering factors for the recurrence of cocaine use are the re-exposure to the drug and stressful events. Cocaine relapse engages the a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85cd66fdb9fb615c17535a5b6e1922dc
https://doi.org/10.3390/ijms22063100

Cardiac adverse effects of naloxone-precipitated morphine withdrawal on right ventricle: Role of corticotropin-releasing factor (CRF) 1 receptor

Autor: Javier Navarro-Zaragoza, Maria Victoria Milanés, L. Mora, María-Luisa Laorden, Elena Martínez-Laorden, Juana M. Hidalgo

Publikováno v: Toxicology and Applied Pharmacology. 275:28-35

Opioid addiction is associated with cardiovascular disease. However, mechanisms linking opioid addiction and cardiovascular disease remain unclear. This study investigated the role of corticotropin-releasing factor (CRF) 1 receptor in mediating somat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef947dd48a4d7a54e54ef2457d903f1
https://doi.org/10.1016/j.taap.2013.12.021

Glucocorticoid receptors participate in the opiate withdrawal-induced stimulation of rats NTS noradrenergic activity and in the somatic signs of morphine withdrawal

Autor: Javier Navarro-Zaragoza, Juana M. Hidalgo, M. Victoria Milanés, M. Luisa Laorden

Publikováno v: British Journal of Pharmacology. 166:2136-2147

BACKGROUND AND PURPOSE Recent evidence suggests that glucocorticoid receptor (GR) is a major molecular substrate of addictive properties of drugs of abuse. Hence, we performed a series of experiments to further characterize the role of GR signalling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6713db6ffc1b06f2bcc8678414529dd9
https://doi.org/10.1111/j.1476-5381.2012.01918.x

Morphine regulates Argonaute 2 and TH expression and activity but not miR-133b in midbrain dopaminergic neurons

Autor: Daniel, García-Pérez, Roger, López-Bellido, Juana M, Hidalgo, Raquel E, Rodríguez, Maria Luisa, Laorden, Cristina, Núñez, Maria Victoria, Milanés

Publikováno v: Addiction biology. 20(1)

Epigenetic changes such as microRNAs (miRs)/Ago2-induced gene silencing represent complex molecular signature that regulate cellular plasticity. Recent studies showed involvement of miRs and Ago2 in drug addiction. In this study, we show that changes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::76257f9c122633081c14718c158f98c9
https://pubmed.ncbi.nlm.nih.gov/23927484