Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Juan-Lorenzo Catena"'
1
A modular click ligand-directed approach to label endogenous aminergic GPCRs in live cells
Autor: Xavier Gómez-Santacana, Marin Boutonnet, Carles Martínez-Juvés, Juan Lorenzo Catena, Enora Moutin, Thomas Roux, Eric Trinquet, Laurent Lamarque, Julie Perroy, Laurent Prézeau, Jurriaan M. Zwier, Jean-Philippe Pin, Amadeu Llebaria
New technologies based on luminescence have been essential to monitor the organization, signaling, trafficking or ligand binding of G Protein-Coupled Receptors (GPCRs), but they rely on the overexpression of genetically modified receptors. As more an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7846be38ae04e927e80c08d155bca71f
http://hdl.handle.net/10261/304936
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2
Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations
Autor: François Hoh, Julie Kniazeff, Juan Lorenzo Catena, Cyril Goudet, Jean-Philippe Pin, Xavier Gómez-Santacana, Anaëlle Dumazer, Jean-Louis Banères, Ludovic Berto, Fanny Malhaire, Amadeu Llebaria, Robert B. Quast, Alice E. Berizzi, Giuseppe Cannone, Kutti R. Vinothkumar, Chia-Ying Huang, Chady Nasrallah, Guillaume Lebon, Julie Briot, Joan Font-Ingles, Karine Rottier
Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2021, 36 (9), pp.109648. ⟨10.1016/j.celrep.2021.109648⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cell Reports, 2021, 36 (9), pp.109648. ⟨10.1016/j.celrep.2021.109648⟩
Summary Metabotropic glutamate receptors (mGluRs) are dimeric G-protein-coupled receptors activated by the main excitatory neurotransmitter, L-glutamate. mGluR activation by agonists binding in the venus flytrap domain is regulated by positive (PAM)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605603c382f708216045efdd1bc23c48
https://hal.archives-ouvertes.fr/hal-03340751/document
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3
Photoswitchable Antagonists for a Precise Spatiotemporal Control of β2-Adrenoceptors
Autor: Amadeu Llebaria, Juan Lorenzo Catena, Anna Duran-Corbera, Marta Otero-Viñas, Xavier Rovira
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
β2-Adrenoceptors (β2-AR) are prototypical G-protein-coupled receptors and important pharmacological targets with relevant roles in physiological processes and diseases. Herein, we introduce Photoazolol-1–3, a series of photoswitchable azobenzene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd077986ab93f6b73818f1b0b9f8998
http://hdl.handle.net/10261/224632
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4
Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator
Autor: Marc López-Cano, Jean-Philippe Pin, Paola Di Pietro, Giuseppe Battaglia, Francisco Ciruela, Pamela Scarselli, Xavier Rovira, Joan Font, Amadeu Llebaria, Cyril Goudet, Jesús Giraldo, Serena Notartomaso, Víctor Fernández-Dueñas, Roger Bresolí-Obach, Juan Lorenzo Catena, Ferdinando Nicoletti, Fanny Malhaire, Santi Nonell
Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
RECERCAT (Dipòsit de la Recerca de Catalunya)
Recercat. Dipósit de la Recerca de Catalunya
instname
eLife, Vol 6 (2017)
eLife
eLife, 2017, 6, ⟨10.7554/elife.23545.001⟩
ResearcherID
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Digital.CSIC. Repositorio Institucional del CSIC
Light-operated drugs constitute a major target in drug discovery, since they may provide spatiotemporal resolution for the treatment of complex diseases (i.e. chronic pain). JF-NP-26 is an inactive photocaged derivative of the metabotropic glutamate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ae4d20420bd24779bc48f39f7d8109
http://hdl.handle.net/2445/122570
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5
Synthesis and biological evaluation of 1,3,4-triaryl-3-pyrrolin-2-ones, a new class of selective cyclooxygenase-2 inhibitors
Autor: Tomas Roca, Juan-Lorenzo Catena, Joan Bosch, Ignasi Miquel, Oriol Llorens, Ana Fernandez‐Serrat, Juan‐Jesus Perez, A.G. Fernández, Carmen Lagunas, Carles Farrerons
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 10:1745-1748
The synthesis and structure–activity relationships (SAR) of a series of novel selective COX-2 inhibitors are reported. The results show that some of the 1,3,4-triaryl-3-pyrrolin-2-ones 1 are more potent as COX-2 inhibitors than celecoxib, and that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d459ee1b476aef94de369040117f46a2
https://doi.org/10.1016/s0960-894x(00)00329-2
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9
ChemInform Abstract: Synthesis and Biological Evaluation of 1,3,4-Triaryl-3-pyrrolin-2-ones, a New Class of Selective Cyclooxygenase-2 Inhibitors
Autor: Carles Farrerons, Ana Fernandez‐Serrat, Joan Bosch, Juan‐Jesus Perez, Juan-Lorenzo Catena, Ignasi Miquel, Oriol Llorens, A.G. Fernández, Carmen Lagunas, Tomas Roca
Publikováno v: ChemInform. 31
The synthesis and structure–activity relationships (SAR) of a series of novel selective COX-2 inhibitors are reported. The results show that some of the 1,3,4-triaryl-3-pyrrolin-2-ones 1 are more potent as COX-2 inhibitors than celecoxib, and that
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66ee4acd2447a48fb127c2600ed74edf
https://doi.org/10.1002/chin.200044128
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