Zobrazeno 1 - 10 of 21 pro vyhledávání: '"Juan-Jesus Vicente"'
1
Akademický článek
The microtubule targeting agent ST-401 triggers cell death in interphase and prevents the formation of polyploid giant cancer cells
Autor: Juan Jesus Vicente, Kainat Khan, Grant Tillinghast, José L. McFaline-Figueroa, Yasemin Sancak, Nephi Stella
Publikováno v: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-20 (2024)
Abstract Microtubule targeting agents (MTAs) are commonly prescribed to treat cancers and predominantly kill cancer cells in mitosis. Significantly, some MTA-treated cancer cells escape death in mitosis, exit mitosis and become malignant polyploid gi
Externí odkaz: https://doaj.org/article/deafb19afc12476097f2997a23be0b83
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2
Akademický článek
A divergent CheW confers plasticity to nucleoid-associated chemosensory arrays.
Autor: Annick Guiseppi, Juan Jesus Vicente, Julien Herrou, Deborah Byrne, Aurelie Barneoud, Audrey Moine, Leon Espinosa, Marie-Jeanne Basse, Virginie Molle, Tâm Mignot, Philippe Roche, Emilia M F Mauriello
Publikováno v: PLoS Genetics, Vol 15, Iss 12, p e1008533 (2019)
Chemosensory systems are highly organized signaling pathways that allow bacteria to adapt to environmental changes. The Frz chemosensory system from M. xanthus possesses two CheW-like proteins, FrzA (the core CheW) and FrzB. We found that FrzB does n
Externí odkaz: https://doaj.org/article/7212312cba80401b9e58be8e974f1e67
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5
Functional characterization of MCAK/Kif2C cancer mutations using high-throughput microscopic analysis
Autor: Linda Wordeman, Sarah Domnitz, Mike Wagenbach, Yulia Ovechkina, Juan Jesus Vicente
Publikováno v: Molecular Biology of the Cell
The microtubule (MT)-depolymerizing activity of MCAK/Kif2C can be quantified by expressing the motor in cultured cells and measuring tubulin fluorescence levels after enough hours have passed to allow tubulin autoregulation to proceed. This method al
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d579c6b213fcff08988e24f258d744
http://europepmc.org/articles/PMC7202071
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6
Microtubule Targeting Agents in Disease: Classic Drugs, Novel Roles
Autor: Linda Wordeman, Juan Jesus Vicente
Publikováno v: Cancers, Vol 13, Iss 5650, p 5650 (2021)
Cancers
Simple Summary Microtubules (MTs) are highly conserved proteins present in all eukaryotic organisms. They form the cell cytoskeleton, and its function is essential for a large number of biological processes. Drugs against MTs (i.e., microtubule-targe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd0328682e85e1a1b476e556ada0c1a
https://www.mdpi.com/2072-6694/13/22/5650
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7
Phosphorylation of NMDA receptors by cyclin B/CDK1 modulates calcium dynamics and mitosis
Autor: Luis Vaca, Arlet Loza-Huerta, Oscar Vivas, Jonathan Pacheco, Claudia M. Moreno, Margarita Jacaranda Rosendo-Pineda, Linda Wordeman, Juan Jesus Vicente, Alicia Sampieri
Publikováno v: Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
N-methyl-D-aspartate receptors (NMDAR) are glutamate-gated calcium channels named after their artificial agonist. NMDAR are implicated in cell proliferation under normal and pathophysiological conditions. However, the role of NMDAR during mitosis has
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892d7b1aab0d475daddb831df359640c
http://europepmc.org/articles/PMC7665045
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8
A divergent CheW confers plasticity to nucleoid-associated chemosensory arrays
Autor: Leon Espinosa, Aurelie Barneoud, Deborah Byrne, Emilia M. F. Mauriello, Virginie Molle, Julien Herrou, Tâm Mignot, Philippe Roche, Marie-Jeanne Basse, Annick Guiseppi, Juan Jesus Vicente, Audrey Moine
Publikováno v: PLoS Genetics
PLoS Genetics, 2019, 15 (12), pp.e1008533. ⟨10.1371/journal.pgen.1008533⟩
PLoS Genetics, Public Library of Science, 2019, 15 (12), pp.e1008533. ⟨10.1371/journal.pgen.1008533⟩
PLoS Genetics, Vol 15, Iss 12, p e1008533 (2019)
Chemosensory systems are highly organized signaling pathways that allow bacteria to adapt to environmental changes. The Frz chemosensory system from M. xanthus possesses two CheW-like proteins, FrzA (the core CheW) and FrzB. We found that FrzB does n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fbd0d7350c504cd7c0f0380f0c50c2c
https://amu.hal.science/hal-02423614/document
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9
The quantification and regulation of microtubule dynamics in the mitotic spindle
Autor: Linda Wordeman, Juan Jesus Vicente
Publikováno v: Curr Opin Cell Biol
Microtubules play essential roles in cellular organization, cargo transport and chromosome segregation during cell division. During mitosis microtubules form a macromolecular structure known as the mitotic spindle that is responsible for the accurate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811c229f368f447f57f604f9419e3407
https://europepmc.org/articles/PMC6756986/
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10
GPR124 regulates microtubule assembly, mitotic progression, and glioblastoma cell proliferation
Autor: Nephi Stella, Shao En Ong, Richard S. Morrison, Cong Xu, Juan Jesus Vicente, Linda Wordeman, Allison E. Cherry
Publikováno v: Glia
GPR124 is involved in embryonic development and remains expressed by select organs. The importance of GPR124 during development suggests that its aberrant expression might participate in tumor growth. Here we show that both increases and decreases in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72b9f3716015b20895beae2e51fd14e
https://pubmed.ncbi.nlm.nih.gov/31058365
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