The treatment effect of novel hGHRH homodimer to male infertility hamster

Autor: Yu-Xia Dong, Song-Shan Tang, Tang Jingxuan, Xiao-Yuan Guo, Tao Liu, Juan-Hui Zhang, Lin-Na Yue, Zhang Xudong

Publikováno v: The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology

Extra-hypothalamic growth hormone-releasing hormone (GHRH) plays an important role in reproduction. To study the treatment effect of Grin (a novel hGHRH homodimer), the infertility models of 85 male Chinese hamsters were established by intraperitonea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc23e053703aa50d3cbdac8c4e56bb3
http://europepmc.org/articles/PMC6205937

Synthesis and biological evaluation of novel structure-related hGHRH agonistic analogs

Autor: Tao Liu, Wen-Feng Wu, You Juan, Dong Zhou, Zhang Xudong, Juan-Hui Zhang, Song-Shan Tang, Hong-Zhi Li, Li Qiuying, Yun-Ke Wang

Publikováno v: Growth Factors. 33:160-168

Activity and half-life play key roles in the application of GHRH analogues. The GHRH monomers produced in a solid synthesizer were incubated, respectively, in NH4OH solution and lyophilized to obtain their dimers. The activities, specificities, and r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb87d9369fa3e0d5e42765b27ada1e5d
https://doi.org/10.3109/08977194.2015.1010644

PC2/CPE-mediated pro-protein processing in tumor cells and its differentiated cells or tissues

Autor: Hong-Zhi Li, Song-Shan Tang, Huan-Xin Liu, Juan-Hui Zhang

Publikováno v: Molecular and Cellular Endocrinology

Pro-protein convertase-2 (PC2) and carboxypeptidase-E (CPE) proteins are two major members of the pro-protein convertases that involve in the maturation of protein precursor. By using PC2 activity, immunocytochemistry (ICC) and Western blot method, P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0bac45d3036f31d632dfc85d8543399
https://doi.org/10.1016/j.mce.2009.01.020

Study on the constructions and activities of three novel hGHRH analogs with N-terminal prolyl modulation+

Autor: Ming-Hua Du, Jie Wu, Xin Kong, Juan-Hui Zhang, Jing-Jing Liu, Song-Shan Tang, Xiao-Wen Zhang

Publikováno v: Regulatory Peptides. 133:20-26

Growth hormone releasing hormone is one of the hormones secreted by the hypothalamus. Because of its potential applications in agriculture and medicine, its short half-life and its expensive chemical synthesis, an analog with high GHRH activity and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd65ae44d8423025c22cfa791fc305eb
https://doi.org/10.1016/j.regpep.2005.09.014

The treatment effect of novel hGHRH homodimer to male infertility hamster.

Autor: Xu-Dong Zhang, Xiao-Yuan Guo, Jing-Xuan Tang, Lin-Na Yue, Juan-Hui Zhang, Tao Liu, Yu-Xia Dong, Song-Shan Tang

Publikováno v: Korean Journal of Physiology & Pharmacology; Nov2018, Vol. 22 Issue 6, p637-647, 11p