Zobrazeno 1 - 10
of 1 018
pro vyhledávání: '"Juan-Carlos Izpisua Belmonte"'
Autor:
Fumiyuki Hatanaka, Keiichiro Suzuki, Kensaku Shojima, Jingting Yu, Yuta Takahashi, Akihisa Sakamoto, Javier Prieto, Maxim Shokhirev, Estrella Nuñez Delicado, Concepcion Rodriguez Esteban, Juan Carlos Izpisua Belmonte
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Defect in the SMN1 gene causes spinal muscular atrophy (SMA), which shows loss of motor neurons, muscle weakness and atrophy. While current treatment strategies, including small molecules or viral vectors, have shown promise in improving mot
Externí odkaz:
https://doaj.org/article/10b9828b196546fa8165e5097af9a12a
Autor:
Yanjiao Shao, Canzhao Liu, Hsin-Kai Liao, Ran Zhang, Baolei Yuan, Hanyan Yang, Ronghui Li, Siting Zhu, Xi Fang, Concepcion Rodriguez Esteban, Ju Chen, Juan Carlos Izpisua Belmonte
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Background Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure. Multiple identified mutations in nexilin (NEXN) have been suggested to be linked with severe DCM. However, the exact association between multiple muta
Externí odkaz:
https://doaj.org/article/11999baaed2c4ab9b5d8511020581917
Autor:
Baolei Yuan, Chongwei Bi, Yeteng Tian, Jincheng Wang, Yiqing Jin, Khaled Alsayegh, Muhammad Tehseen, Gang Yi, Xuan Zhou, Yanjiao Shao, Fernanda Vargas Romero, Wolfgang Fischle, Juan Carlos Izpisua Belmonte, Samir Hamdan, Yanyi Huang, Mo Li
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background CRISPR-Cas9 genome editing often induces unintended, large genomic rearrangements, posing potential safety risks. However, there are no methods for mitigating these risks. Results Using long-read individual-molecule sequencing (ID
Externí odkaz:
https://doaj.org/article/d1681b87d8e041b8a7a543e11f0f1746
Akademický článek
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Autor:
Kaowen Yan, Qianzhao Ji, Dongxin Zhao, Mingheng Li, Xiaoyan Sun, Zehua Wang, Xiaoqian Liu, Zunpeng Liu, Hongyu Li, Yingjie Ding, Si Wang, Juan Carlos Izpisua Belmonte, Jing Qu, Weiqi Zhang, Guang-Hui Liu
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-21 (2023)
Abstract Phase separation, a biophysical segregation of subcellular milieus referred as condensates, is known to regulate transcription, but its impacts on physiological processes are less clear. Here, we demonstrate the formation of liquid-like nucl
Externí odkaz:
https://doaj.org/article/3528fb18768a4b2aa78ac014d4b239b4
Autor:
Marian León, Javier Prieto, María Micaela Molina-Navarro, Francisco García-García, Manuela Barneo-Muñoz, Xavier Ponsoda, Rosana Sáez, Francesc Palau, Joaquín Dopazo, Juan Carlos Izpisua Belmonte, Josema Torres
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Charcot-Marie-Tooth disease is a chronic hereditary motor and sensory polyneuropathy targeting Schwann cells and/or motor neurons. Its multifactorial and polygenic origin portrays a complex clinical phenotype of the disease with a wide range
Externí odkaz:
https://doaj.org/article/446c0345c22f4d3c9e1eea799b58997b
Autor:
Kaowen Yan, Qianzhao Ji, Dongxin Zhao, Mingheng Li, Xiaoyan Sun, Zehua Wang, Xiaoqian Liu, Zunpeng Liu, Hongyu Li, Yingjie Ding, Si Wang, Juan Carlos Izpisua Belmonte, Jing Qu, Weiqi Zhang, Guang-Hui Liu
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/79bd4c34e5924d8fba75585d73d30a09
Autor:
Hui Zhang, Jiaming Li, Yang Yu, Jie Ren, Qiang Liu, Zhaoshi Bao, Shuhui Sun, Xiaoqian Liu, Shuai Ma, Zunpeng Liu, Kaowen Yan, Zeming Wu, Yanling Fan, Xiaoyan Sun, Yixin Zhang, Qianzhao Ji, Fang Cheng, Peng-Hu Wei, Xibo Ma, Shiqiang Zhang, Zhengwei Xie, Yuyu Niu, Yan-Jiang Wang, Jing-Dong J. Han, Tao Jiang, Guoguang Zhao, Weizhi Ji, Juan Carlos Izpisua Belmonte, Si Wang, Jing Qu, Weiqi Zhang, Guang-Hui Liu
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113396- (2023)
Externí odkaz:
https://doaj.org/article/3e6630844d194e75b7324d8432efa3a6
Autor:
Shogo Sato, Tomoaki Hishida, Kenichiro Kinouchi, Fumiaki Hatanaka, Yumei Li, Quy Nguyen, Yumay Chen, Ping H. Wang, Kai Kessenbrock, Wei Li, Juan Carlos Izpisua Belmonte, Paolo Sassone-Corsi
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112590- (2023)
Summary: Distinct metabolic conditions rewire circadian-clock-controlled signaling pathways leading to the de novo construction of signal transduction networks. However, it remains unclear whether metabolic hallmarks unique to pluripotent stem cells
Externí odkaz:
https://doaj.org/article/635f84e16f77448088b48fad1fd43bac
Autor:
Baolei Yuan, Xuan Zhou, Keiichiro Suzuki, Gerardo Ramos-Mandujano, Mengge Wang, Muhammad Tehseen, Lorena V. Cortés-Medina, James J. Moresco, Sarah Dunn, Reyna Hernandez-Benitez, Tomoaki Hishida, Na Young Kim, Manal M. Andijani, Chongwei Bi, Manching Ku, Yuta Takahashi, Jinna Xu, Jinsong Qiu, Ling Huang, Christopher Benner, Emi Aizawa, Jing Qu, Guang-Hui Liu, Zhongwei Li, Fei Yi, Yanal Ghosheh, Changwei Shao, Maxim Shokhirev, Patrizia Comoli, Francesco Frassoni, John R. Yates, Xiang-Dong Fu, Concepcion Rodriguez Esteban, Samir Hamdan, Mo Li, Juan Carlos Izpisua Belmonte
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Wiskott-Aldrich syndrome is caused by mutations in WASP, but the underlying mechanisms remain to be explored. Here the authors reveal that WASP deficiency results in aberrant RNA splicing, and that WASP regulates the transcription of splicing factor
Externí odkaz:
https://doaj.org/article/42d4032a62a14197874f6f1fa9c583d6