Exposure to endocrine disruptor induces transgenerational epigenetic deregulation of microRNAs in primordial germ cells.

Autor: Miguel A Brieño-Enríquez, Jesús García-López, David B Cárdenas, Sylvain Guibert, Elouan Cleroux, Lukas Děd, Juan de Dios Hourcade, Jana Pěknicová, Michael Weber, Jesús Del Mazo

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0124296 (2015)

In mammals, germ cell differentiation is initiated in the Primordial Germ Cells (PGCs) during fetal development. Prenatal exposure to environmental toxicants such as endocrine disruptors may alter PGC differentiation, development of the male germline

Externí odkaz: https://doaj.org/article/2bb7547eaed24a55b3ce1f855c16ef4d

Long-Term Effects of Mouse Intracytoplasmic Sperm Injection with DNA-Fragmented Sperm on Health and Behavior of Adult Offspring1

Autor: Pablo Bermejo-Alvarez, Ainhoa Bilbao, Miriam Pérez-Crespo, Manuel Sánchez-Martín, Eva Pericuesta, Pedro Moreira, Fernando Rodríguez de Fonseca, Miguel Ángel Ramírez, Juan de Dios Hourcade, Raúl Fernández-González, Alfonso Gutiérrez-Adán

Publikováno v: Biology of Reproduction. 78:761-772

Genetic and environmental factors produce different levels of DNA damage in spermatozoa. Usually, DNA-fragmented spermatozoa (DFS) are used with intracytoplasmic sperm injection (ICSI) treatments in human reproduction, and use of DFS is still a matte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e6fd632ce5bbd21488de57befcc597b
https://doi.org/10.1095/biolreprod.107.065623

Exposure to Endocrine Disruptor Induces Transgenerational Epigenetic Deregulation of MicroRNAs in Primordial Germ Cells

Autor: Jesús García-López, Michael Weber, David B. Cárdenas, Jana Pěknicová, Jesús del Mazo, Elouan Cleroux, Sylvain Guibert, Juan de Dios Hourcade, Miguel A. Brieño-Enríquez, Lukas Děd

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2015, 10 (4), pp.e0124296. ⟨10.1371/journal.pone.0124296⟩
PLoS ONE, Vol 10, Iss 4, p e0124296 (2015)

19 p.-6 fig.
In mammals, germ cell differentiation is initiated in the Primordial Germ Cells (PGCs) during fetal development. Prenatal exposure to environmental toxicants such as endocrine disruptors may alter PGC differentiation, development of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1a6a4eed619b5765f53caff72e708f
https://hal.archives-ouvertes.fr/hal-02997146/document

Reprogramming of microRNAs by adenosine-to-inosine editing and the selective elimination of edited microRNA precursors in mouse oocytes and preimplantation embryos

Autor: Jesús García-López, Jesús del Mazo, Juan de Dios Hourcade

Publikováno v: Nucleic Acids Research
Digital.CSIC. Repositorio Institucional del CSIC
instname

11 p.-5 fig.
Adenosine deaminases-acting-on-RNA (ADAR) proteins induce adenosine-to-inosine editing in double-stranded RNA molecules. This editing generates RNA diversity at the post-transcriptional level, and it has been implicated in the contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a23fdfe55b8fe27aef83cc72246eaff
https://pubmed.ncbi.nlm.nih.gov/23571754

In vitro and in vivo development of mice morulae after storage in non-frozen conditions

Autor: Miriam Pérez-Crespo, Belén Pintado, Alfonso Gutiérrez-Adán, Alfredo Serrano, Juan de Dios Hourcade

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Reproductive Biology and Endocrinology, Vol 10, Iss 1, p 62 (2012)
Reproductive Biology and Endocrinology : RB&E
Repositorio de Resultados de Investigación del INIA
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA
INIA: Repositorio de Resultados de Investigación del INIA

Background Interchange of genetically modified (GM) mice between laboratories using embryos provides several advantages. Not only is transport stress avoided, but also the health status of the recipient colony is not compromised. Embryos do not need

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf9be15c92ebf6dc67ec91b524a4496
https://hdl.handle.net/20.500.12792/2126