Abrogation of stemness in osteosarcoma by the mithramycin analog EC-8042 is mediated by its ability to inhibit NOTCH-1 signaling

Autor: Óscar Estupiñán, Verónica Rey, Juan Tornín, Dzohara Murillo, Borja Gallego, Carmen Huergo, Verónica Blanco-Lorenzo, M. Victoria González, Aida Rodríguez, Francisco Moris, Jessica González, Verónica Ayllón, Verónica Ramos-Mejía, Anna Bigas, René Rodríguez

Publikováno v: Biomedicine & Pharmacotherapy, Vol 162, Iss , Pp 114627- (2023)

Osteosarcomas are frequently associated to a poor prognosis and a modest response to current treatments. EC-8042 is a well-tolerated mithramycin analog that has demonstrated an efficient ability to eliminate tumor cells, including cancer stem cell su

Externí odkaz: https://doaj.org/article/492ad1d7684145a88a84802eda9faab7

Proof of concept for the use of trained sniffer dogs to detect osteosarcoma

Autor: Agustín Ortal, Aida Rodríguez, María Pilar Solis-Hernández, Miguel de Prado, Verónica Rey, Juan Tornín, Óscar Estupiñán, Borja Gallego, Dzohara Murillo, Carmen Huergo, Juan Luis García-Llano, Serafín Costilla, René Rodríguez

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)

Abstract Sarcomas are mesenchymal cancers which often show an aggressive behavior and patient survival largely depends on an early detection. In last years, much attention has been given to the fact that cancer patients release specific odorous volat

Externí odkaz: https://doaj.org/article/369cf0eb2bd448c1a0fdf0546c85fa18

Addressing Doxorubicin Resistance in Bone Sarcomas Using Novel Drug-Resistant Models

Autor: Borja Gallego, Dzohara Murillo, Verónica Rey, Carmen Huergo, Óscar Estupiñán, Aida Rodríguez, Juan Tornín, René Rodríguez

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 12, p 6425 (2022)

Bone sarcomas have not shown a significant improvement in survival for decades, due, in part, to the development of resistance to current systemic treatments, such as doxorubicin. To better understand those mechanisms mediating drug-resistance we gen

Externí odkaz: https://doaj.org/article/4f28f4ff1821444796929e1b2fd306fb

Trabectedin and Campthotecin Synergistically Eliminate Cancer Stem Cells in Cell-of-Origin Sarcoma Models

Autor: Lucia Martinez-Cruzado, Juan Tornin, Aida Rodriguez, Laura Santos, Eva Allonca, Maria Teresa Fernandez-Garcia, Aurora Astudillo, Juana Maria Garcia-Pedrero, Rene Rodriguez

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 6, Pp 460-470 (2017)

Trabectedin has been approved for second-line treatment of soft tissue sarcomas. However, its efficacy to target sarcoma initiating cells has not been addressed yet. Here, we used pioneer models of myxoid/round cell liposarcoma (MRCLS) and undifferen

Externí odkaz: https://doaj.org/article/bd15e1b6b66442c8b6da339d6c3a3435

Mithramycin delivery systems to develop effective therapies in sarcomas

Autor: Pilar Clemente-Casares, Francisco Morís, Aitana Vallina-Álvarez, Aida Rodríguez, Verónica Blanco-Lorenzo, Juan Tornin, Oscar Estupiñan, Iván Bravo, Borja Gallego, Carlos Alonso-Moreno, Enrique Niza, M. Victoria Gonzalez, Mar Rodríguez-Santamaría, Daniel Hermida-Merino, Alberto Ocaña, Veronica Rey, Rene Rodriguez

Publikováno v: Journal of Nanobiotechnology
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-21 (2021)
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)

Background Sarcomas comprise a group of aggressive malignancies with very little treatment options beyond standard chemotherapy. Reposition of approved drugs represents an attractive approach to identify effective therapeutic compounds. One example i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b860b74737d16bfeb0ae5b9b435cdb84
http://europepmc.org/articles/PMC8419920