Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Juan Sironi"'
Autor:
Julia S Gelman, Juan Sironi, Iryna Berezniuk, Sayani Dasgupta, Leandro M Castro, Fabio C Gozzo, Emer S Ferro, Lloyd D Fricker
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53263 (2013)
Bortezomib is an antitumor drug that competitively inhibits proteasome beta-1 and beta-5 subunits. While the impact of bortezomib on protein stability is known, the effect of this drug on intracellular peptides has not been previously explored. A qua
Externí odkaz:
https://doaj.org/article/1f7ffa509fdd4f1c90b0b1001dcb0b75
Autor:
Joseph Locker, Steven Keller, Roman Perez-Soler, Jana Sapkar, Jianmin Tian, Dionne Lutz, Juan Sironi, Qiulu Pan, Thomas Harris
CCR Translation for This Article from Both Gene Amplification and Allelic Loss Occur at 14q13.3 in Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b152dc96d16f763e35f2383d52c25c64
https://doi.org/10.1158/1078-0432.22441099
https://doi.org/10.1158/1078-0432.22441099
Publikováno v:
Molecular Pharmacology. 95:127-138
Lysosomes degrade cellular proteins and organelles and regulate cell signaling by providing a surface for the formation of critical protein complexes, notably molecular target of rapamycin (mTOR) complex 1 (mTORC1). Striking differences in the lysoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a559af075e96d4141309bcbb8625ff
https://doi.org/10.1124/mol.118.113118
https://doi.org/10.1124/mol.118.113118
Autor:
Peng Wu, Edward L. Schwartz, Evelyn Aranda, Juan Sironi, Roman Perez-Soler, Jorge Maisonet, Lars Ulrik Nordstrøm
Publikováno v:
ACS Medicinal Chemistry Letters. 6:134-139
The autophagy inhibitors chloroquine (CQ) and hydroxychloroquine (HCQ) have single agent antiproliferative activity against human cancer cell lines; however, low potency may limit their antitumor efficacy clinically. We synthesized a series of chloro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c4169423c4786ae175be855ac00e81
https://doi.org/10.1021/ml500348p
https://doi.org/10.1021/ml500348p
Publikováno v:
Journal of Thoracic Oncology. 8:693-702
Introduction The epidermal growth factor receptor (EGFR) inhibitor erlotinib is much less effective in non–small-cell lung cancer (NSCLC) tumors with wild-type EGFR, than in tumors with activating EGFR mutations. Autophagy is a tightly regulated ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97792a92469645f39218ddc837bd0752
https://doi.org/10.1097/jto.0b013e31828c7210
https://doi.org/10.1097/jto.0b013e31828c7210
Autor:
Juan Sironi, Toru Ouchi
Publikováno v:
Journal of Biological Chemistry. 279:4066-4074
STAT1 (signal transducer and activator of transcription 1) has been implicated as a mediator of a variety of biological responses in response to stimulation by specific growth factors and cytokines. To understand better the role of STAT1 in the inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f154d4027d6c63284d8054a63e4d0b5
https://doi.org/10.1074/jbc.m307774200
https://doi.org/10.1074/jbc.m307774200
Publikováno v:
Cancer Research. 77:3306-3306
Autophagy is an evolutionarily conserved self-defense mechanism that allows tumor cells to overcome stress during oncogenesis and after treatment with chemotherapy. It is the basis of clinical trials using the autophagy inhibitors chloroquine (CQ) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::582c092e3fd3205a2d066f58c6544b6a
https://doi.org/10.1158/1538-7445.am2017-3306
https://doi.org/10.1158/1538-7445.am2017-3306
Autor:
Iryna Berezniuk, Juan Sironi, Ruth Hogue Angeletti, Lloyd D. Fricker, Hui Xiao, Koji Ikegami, Peter J. Lyons, Mitsutoshi Setou
Publikováno v:
The Journal of biological chemistry. 288(42)
Cytosolic carboxypeptidase 5 (CCP5) is a member of a subfamily of enzymes that cleave C-terminal and/or side chain amino acids from tubulin. CCP5 was proposed to selectively cleave the branch point of glutamylated tubulin, based on studies involving
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6096459cbe11346ea999958b0faec8b4
https://pubmed.ncbi.nlm.nih.gov/24022482
https://pubmed.ncbi.nlm.nih.gov/24022482
Autor:
Juan Sironi, Jonathan H. Wardman, Iryna Berezniuk, Bradley K. Yoder, Nicolas F. Berbari, Lloyd D. Fricker, Raymond C. Pasek
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 4, p e60981 (2013)
PLoS ONE, Vol 8, Iss 4, p e60981 (2013)
Cytosolic carboxypeptidase 1 (CCP1) is a metallopeptidase that removes C-terminal and side-chain glutamates from tubulin. The Purkinje cell degeneration (pcd) mouse lacks CCP1 due to a mutation. Previously, elevated levels of peptides derived from cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38743eaa3ece260183572bf34ec0e3e
https://pubmed.ncbi.nlm.nih.gov/23593366
https://pubmed.ncbi.nlm.nih.gov/23593366
Autor:
Lloyd D. Fricker, Hui Xiao, Juan Sironi, Mitsutoshi Setou, Ruth Hogue Angeletti, Koji Ikegami, Berta Burd, Peter J. Lyons, Iryna Berezniuk, Hang T. Vu
The Purkinje cell degeneration (pcd) mouse has a disruption in the gene encoding cytosolic carboxypeptidase 1 (CCP1). This study tested two proposed functions of CCP1: degradation of intracellular peptides and processing of tubulin. Overexpression (2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3adeb8120e826e01e900d5ccf0473ce
https://europepmc.org/articles/PMC3307270/
https://europepmc.org/articles/PMC3307270/