Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Juan Reguera"'
Autor:
Vasiliya Kril, Michael Hons, Celine Amadori, Claire Zimberger, Laurine Couture, Yara Bouery, Julien Burlaud-Gaillard, Andrei Karpov, Denis Ptchelkine, Alexandra L. Thienel, Beate M. Kümmerer, Ambroise Desfosses, Rhian Jones, Philippe Roingeard, Laurent Meertens, Ali Amara, Juan Reguera
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Alphaviruses, such as chikungunya virus (CHIKV), are mosquito-borne viruses that represent a significant threat to human health due to the current context of global warming. Efficient alphavirus infection relies on the activity of the non-st
Externí odkaz:
https://doaj.org/article/392f25030b2e4f8f892df5a32b1b2c86
Autor:
Mikael Feracci, Sergio Hernandez, Laura Garlatti, Clemence Mondielli, Renaud Vincentelli, Bruno Canard, Juan Reguera, François Ferron, Karine Alvarez
Publikováno v:
IUCrJ, Vol 11, Iss 3, Pp 374-383 (2024)
The large Bunyavirales order includes several families of viruses with a segmented ambisense (−) RNA genome and a cytoplasmic life cycle that starts by synthesizing viral mRNA. The initiation of transcription, which is common to all members, relies
Externí odkaz:
https://doaj.org/article/b2e119ae568140c0b04a06af9f5b24e9
Autor:
Quentin Durieux Trouilleton, Sergio Barata-García, Benoît Arragain, Juan Reguera, Hélène Malet
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Hantaviruses are causing life-threatening zoonotic infections in humans. Their tripartite negative-stranded RNA genome is replicated by the multi-functional viral RNA-dependent RNA-polymerase. Here we describe the structure of the Hantaan vi
Externí odkaz:
https://doaj.org/article/cd476297db014ccdaa24dac8c8991fb6
Autor:
Phong Quoc Nguyen, Sonia Huecas, Amna Asif-Laidin, Adrián Plaza-Pegueroles, Beatrice Capuzzi, Noé Palmic, Christine Conesa, Joël Acker, Juan Reguera, Pascale Lesage, Carlos Fernández-Tornero
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Cryo-EM structures of Ty1 integrase-Pol III complexes reveal determinants of Ty1 targeting upstream of Pol III-transcribed genes, and a functional impact of the integrase on Pol III activity that may increase the probability of Ty1 integration.
Externí odkaz:
https://doaj.org/article/ae5e1040373b42eb93f7571525af5479
Autor:
Benoît Arragain, Grégory Effantin, Piotr Gerlach, Juan Reguera, Guy Schoehn, Stephen Cusack, Hélène Malet
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
RNA-dependent RNA polymerases from segmented negative stranded RNA viruses catalyze genome replication and viral transcription. Here, the authors present the cryo-EM structure of full-length La Crosse virus polymerase and structurally characterize th
Externí odkaz:
https://doaj.org/article/5cb62ccd989949bab8fe52127c04e712
Publikováno v:
eLife, Vol 8 (2019)
Negative-strand RNA viruses condense their genome into helical nucleocapsids that constitute essential templates for viral replication and transcription. The intrinsic flexibility of nucleocapsids usually prevents their full-length structural charact
Externí odkaz:
https://doaj.org/article/35d307a2f59e45f69e3760481edac2f3
Autor:
Maria Rosenthal, Nadja Gogrefe, Dominik Vogel, Juan Reguera, Bianka Rauschenberger, Stephen Cusack, Stephan Günther, Sophia Reindl
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006400 (2017)
Cap-snatching was first discovered in influenza virus. Structures of the involved domains of the influenza virus polymerase, namely the endonuclease in the PA subunit and the cap-binding domain in the PB2 subunit, have been solved. Cap-snatching endo
Externí odkaz:
https://doaj.org/article/88e3784547bb46108830eb74a6cc74c5
Autor:
Yaiza Fernández-García, Juan Reguera, Carola Busch, Gregor Witte, Oliberto Sánchez-Ramos, Christian Betzel, Stephen Cusack, Stephan Günther, Sophia Reindl
Publikováno v:
PLoS Pathogens, Vol 12, Iss 6, p e1005635 (2016)
Andes virus (ANDV) is a human-pathogenic hantavirus. Hantaviruses presumably initiate their mRNA synthesis by using cap structures derived from host cell mRNAs, a mechanism called cap-snatching. A signature for a cap-snatching endonuclease is present
Externí odkaz:
https://doaj.org/article/17c13bd61711484db5493f1f68dad5b0
Autor:
Juan Reguera, Piotr Gerlach, Maria Rosenthal, Stephanie Gaudon, Francesca Coscia, Stephan Günther, Stephen Cusack
Publikováno v:
PLoS Pathogens, Vol 12, Iss 6, p e1005636 (2016)
Segmented negative strand RNA viruses of the arena-, bunya- and orthomyxovirus families uniquely carry out viral mRNA transcription by the cap-snatching mechanism. This involves cleavage of host mRNAs close to their capped 5' end by an endonuclease (
Externí odkaz:
https://doaj.org/article/c6fc692a9aa444eab62725017444c33d
Autor:
Juan Reguera, César Santiago, Gaurav Mudgal, Desiderio Ordoño, Luis Enjuanes, José M Casasnovas
Publikováno v:
PLoS Pathogens, Vol 8, Iss 8, p e1002859 (2012)
The coronaviruses (CoVs) are enveloped viruses of animals and humans associated mostly with enteric and respiratory diseases, such as the severe acute respiratory syndrome and 10-20% of all common colds. A subset of CoVs uses the cell surface aminope
Externí odkaz:
https://doaj.org/article/09121afb96c04366991a2c8c63c85b2d