Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Juan Ramón Martínez-François"'
Publikováno v:
Bio-Protocol, Vol 11, Iss 24 (2021)
Genetically encoded fluorescent biosensors are versatile tools for studying brain metabolism and function in live tissue. The genetic information for these biosensors can be delivered into the brain by stereotaxic injection of engineered adeno-associ
Externí odkaz:
https://doaj.org/article/dbfc8636e11b4e3eb575bb2465eeb04b
Autor:
Carlos Manlio Díaz-García, Dylan J Meyer, Nidhi Nathwani, Mahia Rahman, Juan Ramón Martínez-François, Gary Yellen
Publikováno v:
eLife, Vol 10 (2021)
When neurons engage in intense periods of activity, the consequent increase in energy demand can be met by the coordinated activation of glycolysis, the tricarboxylic acid (TCA) cycle, and oxidative phosphorylation. However, the trigger for glycolyti
Externí odkaz:
https://doaj.org/article/456d1aa9a210401faac59803ea384d11
Autor:
Juan Ramón Martínez-François, María Carmen Fernández-Agüera, Nidhi Nathwani, Carolina Lahmann, Veronica L Burnham, Nika N Danial, Gary Yellen
Publikováno v:
eLife, Vol 7 (2018)
Brain metabolism can profoundly influence neuronal excitability. Mice with genetic deletion or alteration of Bad (BCL-2 agonist of cell death) exhibit altered brain-cell fuel metabolism, accompanied by resistance to acutely induced epileptic seizures
Externí odkaz:
https://doaj.org/article/0354aff8c3874c26813144fda6366778
Autor:
Gary Yellen, Loren L. Looger, Mahia Rahman, Jonathan S. Marvin, Nidhi Nathwani, Binsen Li, Carolina Lahmann, Dorothy Koveal, Juan Ramón Martínez-François, Carlos Manlio Diaz-Garcia, Jacob P. Keller
Publikováno v:
Journal of neuroscience research, vol 97, iss 8
Glucose is an essential source of energy for the brain. Recently, the development of genetically encoded fluorescent biosensors has allowed real time visualization of glucose dynamics from individual neurons and astrocytes. A major difficulty for thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06137069c03fd73ff01e43647d6f498c
https://escholarship.org/uc/item/3v81z81x
https://escholarship.org/uc/item/3v81z81x
Autor:
Juan Ramón Martínez-François, María Carmen Fernández-Agüera, Nidhi Nathwani, Carolina Lahmann, Veronica L Burnham, Nika N Danial, Gary Yellen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::257cff479bf50856a6e8fe18200dd31b
https://doi.org/10.7554/elife.32721.018
https://doi.org/10.7554/elife.32721.018
Autor:
María Carmen Fernández-Agüera, Juan Ramón Martínez-François, Nika N. Danial, Gary Yellen, Carolina Lahmann, Veronica L Burnham, Nidhi Nathwani
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife
Brain metabolism can profoundly influence neuronal excitability. Mice with genetic deletion or alteration of Bad (BCL-2 agonist of cell death) exhibit altered brain-cell fuel metabolism, accompanied by resistance to acutely induced epileptic seizures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5a6608075af8db799179705425a203
https://pubmed.ncbi.nlm.nih.gov/30464738
https://pubmed.ncbi.nlm.nih.gov/30464738
Publikováno v:
Ketogenic Diet and Metabolic Therapies ISBN: 0190497998
Ketogenic Diet and Metabolic Therapies ISBN: 0197501206
Ketogenic Diet and Metabolic Therapies ISBN: 0197501206
Ketogenic diets are a very effective treatment for epilepsy. On a ketogenic diet, ketone bodies provide an alternative brain fuel, replacing much of the glucose ordinarily used by the brain. This change in fuel utilization may alter neuronal excitabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90763de9ad88cca3afb9e251f8507ec5
https://doi.org/10.1093/med/9780190497996.003.0028
https://doi.org/10.1093/med/9780190497996.003.0028
Autor:
Gary Yellen, Jill K. Fisher, Jessica Wiwczar, Alfredo Giménez-Cassina, Benjamin Szlyk, Andrew Lutas, Klaudia Polak, Geoffrey R. Tanner, Nika N. Danial, Juan Ramón Martínez-François
Publikováno v:
Neuron. 74:719-730
SummaryNeuronal excitation can be substantially modulated by alterations in metabolism, as evident from the anticonvulsant effect of diets that reduce glucose utilization and promote ketone body metabolism. We provide genetic evidence that BAD, a pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8857a3d769ad5ceb300c33e16da5aea8
https://doi.org/10.1016/j.neuron.2012.03.032
https://doi.org/10.1016/j.neuron.2012.03.032
Autor:
Juan Ramón Martínez-François, Zhe Lu
Publikováno v:
The Journal of General Physiology
Many physiological and synthetic agents act by occluding the ion conduction pore of ion channels. A hallmark of charged blockers is that their apparent affinity for the pore usually varies with membrane voltage. Two models have been proposed to expla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ca0d665d25c9ae75948d01b0079e10
https://doi.org/10.1085/jgp.200910324
https://doi.org/10.1085/jgp.200910324