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of 5
pro vyhledávání: '"Juan R. Perea"'
Autor:
Juan R. Perea, Esther García, Laura Vallés-Saiz, Raquel Cuadros, Félix Hernández, Marta Bolós, Jesús Avila
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Tauopathies are a group of neurodegenerative diseases characterized by the accumulation of hyperphosphorylated tau protein in the brain. Many of these pathologies also present an inflammatory component determined by the activation of microgl
Externí odkaz:
https://doaj.org/article/9799048a1e7449c4a843344f9a985dc8
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the presence of neurofibrillary tangles, constituted by tau protein, and plaques formed by amyloid-beta protein. The disease courses with high neural damage, which leads to me
Externí odkaz:
https://doaj.org/article/a8a04a2682f24f0c844632f641315e6a
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Tauopathies are neurodegenerative diseases which course with the accumulation of Tau, mainly in neurons. In addition, Tau accumulates in a hyperphosphorylated and aggregated form. This protein is released into the extracellular space and spreads foll
Externí odkaz:
https://doaj.org/article/65d130ddeb19485a874d627528cfff23
Autor:
Jesús Avila, María Llorens-Martín, Noemí Pallas-Bazarra, Marta Bolós, Juan R. Perea, Alberto Rodríguez-Matellán, Félix Hernández
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
Molecular changes associated with neuronal aging lead to a decrease in cognitive capacity. Here we discuss these alterations at the level of brain regions, brain cells, and brain membrane and cytoskeletal proteins with an special focus in NMDA molecu
Externí odkaz:
https://doaj.org/article/63b9d0017b8d41898f75dd5918b3edac
Autor:
Juan R. Perea, Marta Bolós, Raquel Cuadros, Esther García, Vega García-Escudero, Félix Hernández, Róisín M. McManus, Michael T. Heneka, Jesús Avila
Publikováno v:
Molecular neurobiology 59(3), 1632-1648 (2022). doi:10.1007/s12035-021-02715-0
Alzheimer’s disease (AD) and other tauopathies are histopathologically characterized by tau aggregation, along with a chronic inflammatory response driven by microglia. Over the past few years, the role of microglia in AD has been studied mainly in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea3c4c4c2a156c1ca73f265132f7c83
https://pubmed.ncbi.nlm.nih.gov/35006531
https://pubmed.ncbi.nlm.nih.gov/35006531