Arginine and lysine transporters are essential for Trypanosoma brucei

Autor: Daniel Hürlimann, Peter Bütikofer, Doris Rentsch, Amaia Gonzalez-Salgado, Corina Wirdnam, Christoph Mathieu, Alexander C. Haindrich, Remo S. Schmidt, Ehud Inbar, Pascal Mäser, Marianne Suter Grotemeyer, Juan Pereira de Macêdo, Dan Zilberstein

Publikováno v: PLoS ONE
Mathieu, Christoph; Pereira de Macêdo, Juan; Hürlimann, Daniel; Wirdnam, Corina; Haindrich, Alexander; Suter, Marianne; González Salgado, Amaia; Schmidt, Remo; Inbar, Ehud; Mäser, Pascal; Bütikofer, Peter; Zilberstein, Dan; Rentsch, Doris (2017). Arginine and Lysine Transporters Are Essential for Trypanosoma brucei. PLoS ONE, 12(1), e0168775. Public Library of Science 10.1371/journal.pone.0168775
PLoS ONE, Vol 12, Iss 1, p e0168775 (2017)

For Trypanosoma brucei arginine and lysine are essential amino acids and therefore have to be imported from the host. Heterologous expression in Saccharomyces cerevisiae mutants identified cationic amino acid transporters among members of the T. bruc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::822826d2c5f1f9a7ae2566bca9058a5f

Identification and characterization of the three members of the CLC family of anion transport proteins in Trypanosoma brucei

Autor: Christina Kunz Renggli, Peter Bütikofer, Doris Rentsch, Michael E. Steinmann, Juan Pereira de Macêdo, Erwin Sigel, Remo S. Schmidt, Pascal Mäser

Publikováno v: PLoS ONE
Steinmann, Michael E.; Schmidt, Remo S.; Pereira de Macêdo, Juan; Kunz Renggli, Christina; Bütikofer, Peter; Rentsch, Doris; Mäser, Pascal; Sigel, Erwin (2017). Identification and characterization of the three members of the CLC family of anion transport proteins in Trypanosoma brucei. PLoS ONE, 12(12), pp. 1-18. Public Library of Science 10.1371/journal.pone.0188219
PLoS ONE, Vol 12, Iss 12, p e0188219 (2017)

CLC type anion transport proteins are homo-dimeric or hetero-dimeric with an integrated transport function in each subunit. We have identified and partially characterized three members of this family named TbVCL1, TbVCL2 and TbVCL3 in Trypanosoma bru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801df6f906ed7764184c5b6454517f23
https://doi.org/10.1371/journal.pone.0188219

NADPH phagocyte oxidase knockout mice control Trypanosoma cruzi proliferation, but develop circulatory collapse and succumb to infection

Autor: Mauro M. Teixeira, Leda Quercia Vieira, Maria José Campagnole-Santos, Fernando Q. Cunha, Claudia Gonzalez Lombana, Wagner Luiz Tafuri, Helton C. Santiago, Rosana O. Alves, Alvaro J. Romanha, José C. Alves-Filho, Rafael Radi, Juan Pereira de Macêdo, L. Utsch

Publikováno v: PLoS Neglected Tropical Diseases
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS Neglected Tropical Diseases, Vol 6, Iss 2, p e1492 (2012)

•NO is considered to be a key macrophage-derived cytotoxic effector during Trypanosoma cruzi infection. On the other hand, the microbicidal properties of reactive oxygen species (ROS) are well recognized, but little importance has been attributed t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1326c9ec0485b9e899057c697b001e38
https://pubmed.ncbi.nlm.nih.gov/22348160

Impact of reactive oxygen species (ROS) on the control of parasite loads and inflammation in Leishmania amazonensis infection

Autor: Leda Quercia Vieira, Daniel Cisalpino, Juan Pereira de Macêdo, Juliana Lauar Gonçalves, Eric Henrique Roma, Waldionê de Castro, Grazielle Ribeiro Goes

Publikováno v: Parasites & Vectors
Roma, Eric Henrique; Pereira de Macêdo, Juan; Goes, Grazielle Ribeiro; Gonçalves, Juliana Lauar; Castro, Waldionê de; Cisalpino, Daniel; Vieira, Leda Quercia (2016). Impact of reactive oxygen species (ROS) on the control of parasite loads and inflammation in Leishmania amazonensis infection. Parasites & Vectors, 9(1), p. 193. BioMed Central 10.1186/s13071-016-1472-y

Background: Reactive oxygen species (ROS) protect the host against a large number of pathogenic microorganisms. ROS have different effects on parasites of the genus Leishmania: some parasites are susceptible to their action, while others seem to be r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e44edfaf49017ea07d1d806ebbeb57fe