Výsledky vyhledávání - "Juan Pablo Salica"

Alpha-1-antitrypsin ameliorates inflammation and neurodegeneration in the diabetic mouse retina

Autor: Constanza Potilinski, Mariano Fernández Acquier, Emiliano López, Eduardo Chuluyan, Gustavo Ortiz, Juan Pablo Salica, Juan E Gallo

Publikováno v: Experimental Eye Research. 174:29-39

Diabetic retinopathy (DR) is the most common cause of blindness in the working age population. Early events of DR are accompanied by neurodegeneration of the inner retina resulting in ganglion cell loss. These findings together with reduced retinal t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b64f5981587710760644756865ef94
https://doi.org/10.1016/j.exer.2018.05.013

Zobrazit plný text záznamu

Elucidating the mechanism of action of alpha-1-antitrypsin using retinal pigment epithelium cells exposed to high glucose. Potential use in diabetic retinopathy

Autor: Emiliano López, Juan Pablo Salica, María Constanza Potilinski, Juan E Gallo, Gustavo Ortiz, Mariano Fernández Acquier, Eduardo Chuluyan

Publikováno v: PLoS ONE
PLoS ONE, Vol 15, Iss 2, p e0228895 (2020)

Background Alpha-1-antitrypsin is a protein involved in avoidance of different processes that are seen in diabetic retinopathy pathogenesis. These processes include apoptosis, extracellular matrix remodeling and damage of vessel walls and capillaries

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbdc02a1d536982e6b0b60957d5f552a
https://doi.org/10.1371/journal.pone.0228895

Zobrazit plný text záznamu

Possible neuroprotective role of P2X2 in the retina of diabetic rats

Autor: Emiliano López, Constanza Potilinstki, J. Oscar Croxatto, Jorge Mancini, Gustavo Ortiz, Juan E Gallo, Juan Pablo Salica

Publikováno v: Diabetology & Metabolic Syndrome, Vol 10, Iss 1, Pp 1-12 (2018)
Diabetology & Metabolic Syndrome
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Background: Purinergic receptors are expressed in different tissues including the retina. These receptors are involved in processes like cell growth, proliferation, activation and survival. ATP is the major activator of P2 receptors. In diabetes, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eeeda3e4290972753b278e9ef9566c4
https://dmsjournal.biomedcentral.com/articles/10.1186/s13098-018-0332-7

Zobrazit plný text záznamu

Diabetic retinopathy: could the alpha-1 antitrypsin be a therapeutic option?

Autor: Juan Pablo Salica, Eduardo Chuluyan, Juan E Gallo, Gustavo Ortiz

Publikováno v: Biological Research, Vol 47, Iss 0, Pp 1-9 (2014)
Biological Research v.47 2014
SciELO Chile
CONICYT Chile
instacron:CONICYT
Biological Research
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Biological Research, Volume: 47, Pages: 1-9, Published: 2014

Diabetic retinopathy is one of the most important causes of blindness. The underlying mechanisms of this disease include inflammatory changes and remodeling processes of the extracellular-matrix (ECM) leading to pericyte and vascular endothelial cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2e7d7193bc76372d95321f997630df6
https://biolres.biomedcentral.com/articles/10.1186/0717-6287-47-58

Zobrazit plný text záznamu

Transglutaminase binding fusion protein linked to SLPI reduced corneal inflammation and neovascularization

Autor: Juan Pablo Salica, Diego Guerrieri, H. Eduardo Chuluyan, Paulo Cesar Maffia, Juan E Gallo, J. O. Croxatto

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
BMC Ophthalmology

Background: To study the effect of topical administration of a fusion protein (PF-MC) made up of N-terminal portion of the protease inhibitor Trappin-2 (which is a substrate of transglutaminasa-2) and SLPI (protein with anti-inflammatory, anti-bacter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a79f5f403bf230518bb2c3cee8bbb598

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání