Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Juan Pablo Palavicini"'
Autor:
Yong Ge, Changjun Yang, Mojgan Zadeh, Shane M. Sprague, Yang-Ding Lin, Heetanshi Sanjay Jain, Brenden Fitzgerald Determann, II, William H. Roth, Juan Pablo Palavicini, Jonathan Larochelle, Eduardo Candelario-Jalil, Mansour Mohamadzadeh
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109480- (2024)
Summary: Ischemic stroke is the second leading cause of death and disability worldwide, and efforts to prevent stroke, mitigate secondary neurological damage, and promote neurological recovery remain paramount. Recent findings highlight the critical
Externí odkaz:
https://doaj.org/article/582214adb88045e692a188fba6a6f725
Autor:
Shulan Qiu, Juan Pablo Palavicini, Jianing Wang, Nancy S. Gonzalez, Sijia He, Elizabeth Dustin, Cheng Zou, Lin Ding, Anindita Bhattacharjee, Candice E. Van Skike, Veronica Galvan, Jeffrey L. Dupree, Xianlin Han
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-24 (2021)
Abstract Background Human genetic association studies point to immune response and lipid metabolism, in addition to amyloid-beta (Aβ) and tau, as major pathways in Alzheimer’s disease (AD) etiology. Accumulating evidence suggests that chronic neur
Externí odkaz:
https://doaj.org/article/7968af0cadaf4aba9fed3628e5117c8b
Autor:
Elizabeth Dustin, Edna Suarez-Pozos, Camryn Stotesberry, Shulan Qiu, Juan Pablo Palavicini, Xianlin Han, Jeffrey L. Dupree
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1431 (2023)
3-O-sulfogalactosylceramide, or sulfatide, is a prominent myelin glycosphingolipid reduced in the normal appearing white matter (NAWM) in Multiple Sclerosis (MS), indicating that sulfatide reduction precedes demyelination. Using a mouse model that is
Externí odkaz:
https://doaj.org/article/1d2f112626b94201876886b0f33dc555
Autor:
Chris E. Shannon, Mukundan Ragavan, Juan Pablo Palavicini, Marcel Fourcaudot, Terry M Bakewell, Ivan A. Valdez, Iriscilla Ayala, Eunsook S. Jin, Muniswamy Madesh, Xianlin Han, Matthew E. Merritt, Luke Norton
Publikováno v:
Molecular Metabolism, Vol 45, Iss , Pp 101154- (2021)
Objective: Insulin resistance and altered hepatic mitochondrial function are central features of type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD), but the etiological role of these processes in disease progression remains unclear.
Externí odkaz:
https://doaj.org/article/67c698d87fe047148632cbaa851c76cd
Autor:
Ashish Singha, Juan Pablo Palavicini, Meixia Pan, Scotlynn Farmer, Darleen Sandoval, Xianlin Han, Teppei Fujikawa
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Leptin is a potent endocrine hormone produced by adipose tissue and regulates a broad range of whole-body metabolism such as glucose and lipid metabolism, even without insulin. Central leptin signaling can lower hyperglycemia in insulin-deficient rod
Externí odkaz:
https://doaj.org/article/cfc92c31dbac45a0bbdd6e77bf8cd508
Autor:
Juan Pablo Palavicini, Chunyan Wang, Linyuan Chen, Kristen Hosang, Jianing Wang, Takami Tomiyama, Hiroshi Mori, Xianlin Han
Publikováno v:
Acta Neuropathologica Communications, Vol 5, Iss 1, Pp 1-17 (2017)
Abstract Alzheimer’s disease (AD) is histopathologically characterized by the build-up of fibrillar amyloid beta (Aβ) in the form of amyloid plaques and the development of intraneuronal neurofibrillary tangles consisting of aggregated hyperphospho
Externí odkaz:
https://doaj.org/article/1efde33df074468299e8bb8bb06034a0
Autor:
Ruizhi Wang, Juan Pablo Palavicini, Hongjie Wang, Panchanan Maiti, Elisabetta Bianchi, Shaohua Xu, B.N. Lloyd, Ken Dawson-Scully, David E. Kang, Madepalli K. Lakshmana
Publikováno v:
Neurobiology of Disease, Vol 69, Iss , Pp 169-179 (2014)
We previously demonstrated that RanBP9 overexpression increased Aβ generation and amyloid plaque burden, subsequently leading to robust reductions in the levels of several synaptic proteins as well as deficits in the learning and memory skills in a
Externí odkaz:
https://doaj.org/article/b768ae3adbf34dc39e60b09ac383056f
Autor:
Juan Pablo Palavicini, Brandon Noel Lloyd, Crystal D Hayes, Elisabetta Bianchi, David E Kang, Ken Dawson-Scully, Madepalli K Lakshmana
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66908 (2013)
RanBP9 is known to act as a scaffolding protein bringing together a variety of cell surface receptors and intracellular targets thereby regulating functions as diverse as neurite and axonal outgrowth, cell morphology, cell proliferation, myelination,
Externí odkaz:
https://doaj.org/article/34b58bd3404f42088f05316607744c4c
Autor:
Crystal D Hayes, Debleena Dey, Juan Pablo Palavicini, Hongjie Wang, Wataru Araki, Madepalli K Lakshmana
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e45841 (2012)
The clinical uses of 2-chloro-2'-deoxyadenosine (2-CDA) or cladribine which was initially prescribed to patients with hematological and lymphoid cancers is now extended to treat patients with multiple sclerosis (MS). Previous data has shown that 2-CD
Externí odkaz:
https://doaj.org/article/491487c0b14c44aaac9104b9c2535475
Publikováno v:
PLoS Biology, Vol 8, Iss 11, p e1000540 (2010)
Because firing properties and metabolic rates vary widely, neurons require different transport rates from their Na(+)/K(+) pumps in order to maintain ion homeostasis. In this study we show that Na(+)/K(+) pump activity is tightly regulated by a novel
Externí odkaz:
https://doaj.org/article/1977788058b2453f98f816a9b88510ff