Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Juan P. Fusco"'
Autor:
Ana Patiño-García, Elizabeth Guruceaga, Maria Pilar Andueza, Marimar Ocón, Jafait Junior Fodop Sokoudjou, Nicolás de Villalonga Zornoza, Gorka Alkorta-Aranburu, Ibon Tamayo Uria, Alfonso Gurpide, Carlos Camps, Eloísa Jantus-Lewintre, Maria Navamuel-Andueza, Miguel F. Sanmamed, Ignacio Melero, Mohamed Elgendy, Juan Pablo Fusco, Javier J. Zulueta, Juan P. de-Torres, Gorka Bastarrika, Luis Seijo, Ruben Pio, Luis M. Montuenga, Mikel Hernáez, Idoia Ochoa, Jose Luis Perez-Gracia
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105048- (2024)
Summary: Background: Tobacco is the main risk factor for developing lung cancer. Yet, while some heavy smokers develop lung cancer at a young age, other heavy smokers never develop it, even at an advanced age, suggesting a remarkable variability in t
Externí odkaz:
https://doaj.org/article/325b5d8d436b42f0be4be23054440e34
Autor:
Juan Pablo Fusco, Guillermo Pita, María José Pajares, Maria Pilar Andueza, Ana Patiño‐García, Juan P. de‐Torres, Alfonso Gurpide, Javier Zulueta, Rosario Alonso, Nuria Alvarez, Ruben Pio, Ignacio Melero, Miguel F. Sanmamed, Maria Rodriguez Ruiz, Ignacio Gil‐Bazo, Jose María Lopez‐Picazo, Ciro Casanova, Rebeca Baz Davila, Antonio Agudo, Maria Dolores Lozano, Alvaro Gonzalez, Nuria Sala, Eva Ardanaz, Javier Benitez, Luis Montuenga, Anna Gonzalez‐Neira, Jose Luis Perez‐Gracia
Publikováno v:
Cancer Medicine, Vol 7, Iss 7, Pp 3474-3483 (2018)
Abstract Single nucleotide polymorphisms (SNPs) may modulate individual susceptibility to carcinogens. We designed a genome‐wide association study to characterize individuals presenting extreme phenotypes of high and low risk to develop tobacco‐i
Externí odkaz:
https://doaj.org/article/c3b285810a764be5ae798d81e210d99b
Autor:
Ignacio Melero, Jose L. Perez-Gracia, Pedro Berraondo, Jose Medina-Echeverz, Marcello Allegretti, Maria De Pizzol, Susana Inogés, Angela Aznar, Juan P. Fusco, Saray Garasa, Alfonso Rodriguez-Paulete, Arantza Azpilikueta, Sara Labiano, Diego Alignani, Maria Pilar Andueza, Miguel F. Sanmamed, Guiomar Pérez, Carmen Oñate, Alvaro Teijeira, Carlos Alfaro
Supplementary figure 1. Comparative spleen size in tumor-free mice and mice engrafted with CT26-GMCSF tumors for 21 days. Photographs taken in parallel upon necropsy of the indicated group of mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891f7f025645c69507d44b8bb9e35a69
https://doi.org/10.1158/1078-0432.22457465
https://doi.org/10.1158/1078-0432.22457465
Autor:
Ignacio Melero, Jose L. Perez-Gracia, Pedro Berraondo, Jose Medina-Echeverz, Marcello Allegretti, Maria De Pizzol, Susana Inogés, Angela Aznar, Juan P. Fusco, Saray Garasa, Alfonso Rodriguez-Paulete, Arantza Azpilikueta, Sara Labiano, Diego Alignani, Maria Pilar Andueza, Miguel F. Sanmamed, Guiomar Pérez, Carmen Oñate, Alvaro Teijeira, Carlos Alfaro
Supplementary figure 2. IL-8 hydrodynamic gene transfer effects on tumor free mice. Hydrodynamic gene transfer experiments as in figure 2 but performed in tumor-free mice. Results show the content of the indicated cell subsets in the liver and spleen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349fba7d55691597e508d69c76ee567f
https://doi.org/10.1158/1078-0432.22457462
https://doi.org/10.1158/1078-0432.22457462
Autor:
Ignacio Melero, Jose L. Perez-Gracia, Pedro Berraondo, Jose Medina-Echeverz, Marcello Allegretti, Maria De Pizzol, Susana Inogés, Angela Aznar, Juan P. Fusco, Saray Garasa, Alfonso Rodriguez-Paulete, Arantza Azpilikueta, Sara Labiano, Diego Alignani, Maria Pilar Andueza, Miguel F. Sanmamed, Guiomar Pérez, Carmen Oñate, Alvaro Teijeira, Carlos Alfaro
Supplementary figure 3. Number of MDSC in peripheral blood of patients using osmotic lysis of erythrocytes instead of samples from ficoll-gradient centrifugation. Experiments as those shown in figure 3B representing the percentage of positively stain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a53993cedcd96a0b68650d98045d85
https://doi.org/10.1158/1078-0432.22457459
https://doi.org/10.1158/1078-0432.22457459
Autor:
Ignacio Melero, Jose L. Perez-Gracia, Pedro Berraondo, Jose Medina-Echeverz, Marcello Allegretti, Maria De Pizzol, Susana Inogés, Angela Aznar, Juan P. Fusco, Saray Garasa, Alfonso Rodriguez-Paulete, Arantza Azpilikueta, Sara Labiano, Diego Alignani, Maria Pilar Andueza, Miguel F. Sanmamed, Guiomar Pérez, Carmen Oñate, Alvaro Teijeira, Carlos Alfaro
Supplementary video 2. IL-8 induces NET extrusion of GrMDSCs to entrap or adhere HT29 tumor cells. GrMDSCs nuclei were pre-stained with DRAQ5, (cyan), HT29 cells with PKH26 cell membrane dye (Red seen intracellular vesicles) and treated or not with I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e16ecec529efcb192b4f1669466bd9
https://doi.org/10.1158/1078-0432.22457447.v1
https://doi.org/10.1158/1078-0432.22457447.v1
Autor:
Ignacio Melero, Jose L. Perez-Gracia, Pedro Berraondo, Jose Medina-Echeverz, Marcello Allegretti, Maria De Pizzol, Susana Inogés, Angela Aznar, Juan P. Fusco, Saray Garasa, Alfonso Rodriguez-Paulete, Arantza Azpilikueta, Sara Labiano, Diego Alignani, Maria Pilar Andueza, Miguel F. Sanmamed, Guiomar Pérez, Carmen Oñate, Alvaro Teijeira, Carlos Alfaro
Supplementary video 1. IL-8 induces NET extrusion of GrMDSCs using time-lapse in vivo confocal fluorescence microsocopy. GrMDSCs nuclei were pre-stained with DRAQ5 (Red) and treated with IL-8. The non-cell permeant green DNA probe (SYTOXgreen) is pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1e8f2456484c2e7a190bc14379052d
https://doi.org/10.1158/1078-0432.22457468
https://doi.org/10.1158/1078-0432.22457468
Autor:
Ignacio Melero, Jose L. Perez-Gracia, Pedro Berraondo, Jose Medina-Echeverz, Marcello Allegretti, Maria De Pizzol, Susana Inogés, Angela Aznar, Juan P. Fusco, Saray Garasa, Alfonso Rodriguez-Paulete, Arantza Azpilikueta, Sara Labiano, Diego Alignani, Maria Pilar Andueza, Miguel F. Sanmamed, Guiomar Pérez, Carmen Oñate, Alvaro Teijeira, Carlos Alfaro
Supplementary figure 6. IL-8 induction of NETs on GrMDSC is dose dependent, similar in intensity to that induced by LPS and can be blocked by IL-8 neutralizing antibodies. (A and B) Experiments as those in figure 6 showing the indicated conditions NE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a996df5d348d92040116d1beb09dd94b
https://doi.org/10.1158/1078-0432.22457450
https://doi.org/10.1158/1078-0432.22457450
Autor:
Ignacio Melero, Jose L. Perez-Gracia, Pedro Berraondo, Jose Medina-Echeverz, Marcello Allegretti, Maria De Pizzol, Susana Inogés, Angela Aznar, Juan P. Fusco, Saray Garasa, Alfonso Rodriguez-Paulete, Arantza Azpilikueta, Sara Labiano, Diego Alignani, Maria Pilar Andueza, Miguel F. Sanmamed, Guiomar Pérez, Carmen Oñate, Alvaro Teijeira, Carlos Alfaro
Purpose: Myeloid-derived suppressor cells (MDSC) are considered an important T-cell immunosuppressive component in cancer-bearing hosts. The factors that attract these cells to the tumor microenvironment are poorly understood. IL8 (CXCL8) is a potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864ce283901aa0d5261bc24d322dec01
https://doi.org/10.1158/1078-0432.c.6523583
https://doi.org/10.1158/1078-0432.c.6523583
Autor:
Ignacio Melero, Jose L. Perez-Gracia, Pedro Berraondo, Jose Medina-Echeverz, Marcello Allegretti, Maria De Pizzol, Susana Inogés, Angela Aznar, Juan P. Fusco, Saray Garasa, Alfonso Rodriguez-Paulete, Arantza Azpilikueta, Sara Labiano, Diego Alignani, Maria Pilar Andueza, Miguel F. Sanmamed, Guiomar Pérez, Carmen Oñate, Alvaro Teijeira, Carlos Alfaro
Supplementary figure 5. Suppressive activity of MoMDSC on autologous purified CD4 and CD8 T cells. Experiments as in figure 5 but in this case immunomagnetically purified T cells by negative selection were CFSE-labeled co-cultured as indicated. T lym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a06710cc724798a0a41b7944c89ff330
https://doi.org/10.1158/1078-0432.22457453.v1
https://doi.org/10.1158/1078-0432.22457453.v1