Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Juan P. Fernandez de Castro"'
Publikováno v:
Taiwan Journal of Ophthalmology. 2:41-44
Retinitis pigmentosa (RP) is the leading cause of hereditary blindness, and there is currently no available treatment that can either significantly slow the progression of this disease or restore lost vision. Amphibians and birds exhibit different st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858cd53ea2c319fec784db2ef2f0cb6f
https://doi.org/10.1016/j.tjo.2012.03.003
https://doi.org/10.1016/j.tjo.2012.03.003
Autor:
Julie H. Sandell, Xiaoyan Peng, Maureen A. McCall, Henry J. Kaplan, Juan P. Fernandez de Castro, Patrick A. Scott, Paul J. DeMarco, Wei Wang, L. M. Franco, Eric V. Vukmanic, Jennifer M. Noel
Publikováno v:
Experimental Eye Research. 97:137-147
Our purpose was to find a method to create a large animal model of inducible photoreceptor damage. To this end, we tested in domestic swine the efficacy of two chemical toxins, known to create photoreceptor damage in other species: Iodoacetic Acid (I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9308169658a77d2046f39589c692454
https://doi.org/10.1016/j.exer.2011.12.018
https://doi.org/10.1016/j.exer.2011.12.018
Autor:
Daniel Palanker, Henry J. Kaplan, Adewumi N. Adekunle, Machelle T. Pardue, Maureen A. McCall, Alice Adkins, Sang Joon Lee, Wei Wang, Juan P. Fernandez de Castro, Philip Huie
Purpose To investigate the integration of subretinal implants containing full-depth perforations of various widths with rat and pig retina across weeks of implantation. Methods In transgenic P23H rhodopsin line 1 (TgP23H-1) rats and wild-type (WT) pi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8513a9956b23663ff854dc58320311f3
https://europepmc.org/articles/PMC4539203/
https://europepmc.org/articles/PMC4539203/
Autor:
Josephat G. Njoka, Randall S. Prather, Juan P. Fernandez de Castro, Eric M. Walters, Paul J. DeMarco, Maureen A. McCall, Jason W. Ross, Henry J. Kaplan, Patrick A. Scott
Publikováno v:
Translational Vision Science & Technology
Purpose We characterize the progression of retinopathy in Filial 1 (F1) progeny of a transgenic (Tg) founder miniswine exhibiting severe Pro23His (P23H) retinopathy. Methods The F1 TgP23H miniswine progeny were created by crossing TgP23H founder mini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e74d521e26dcd869f276e12b70984e
https://doi.org/10.1167/tvst.6.2.4
https://doi.org/10.1167/tvst.6.2.4
Autor:
James Demas, Juan P. Fernandez de Castro, Maureen A. McCall, Patrick A. Scott, Henry J. Kaplan, Paul J. DeMarco, James W Fransen
Publikováno v:
Investigative ophthalmologyvisual science. 55(4)
Purpose Human and swine retinas have morphological and functional similarities. In the absence of primate models, the swine is an attractive model to study retinal function and disease, with its cone-rich visual streak, our ability to manipulate thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afff01aa756b4f3166fdb7806a6eb488
https://pubmed.ncbi.nlm.nih.gov/24618325
https://pubmed.ncbi.nlm.nih.gov/24618325
Autor:
Rintaro Tsukahara, LanHsin Liu, Henry J. Kaplan, Kazuhiko Umazume, Kevin McDonald, Juan P. Fernandez de Castro, Shigeo Tamiya
Publikováno v:
The American journal of pathology. 184(5)
Proliferative vitreoretinopathy is caused by the contraction of fibrotic membranes on the epiretinal surface of the neurosensory retina, resulting in a traction retinal detachment and loss of visual acuity. Retinal pigment epithelial (RPE) cells play
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693fcb8afde936e89c86d6ab96e7add7
https://pubmed.ncbi.nlm.nih.gov/24656918
https://pubmed.ncbi.nlm.nih.gov/24656918
Autor:
Wei Wang, Henry J. Kaplan, Liang Zhou, Eric V. Vukmanic, Douglas Emery, Juan P. Fernandez de Castro, Paul J. DeMarco, Douglas C. Dean
Publikováno v:
Investigative ophthalmologyvisual science. 52(11)
Retinitis pigmentosa (RP) and age-related macular degeneration (AMD) represent two major retinal degenerative diseases that lead progressively to blindness. Both RP and AMD target photoreceptors constituting the outer retina. Unlike lower vertebrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf06f293aaaf210ca4aac193055bab5
https://pubmed.ncbi.nlm.nih.gov/21896868
https://pubmed.ncbi.nlm.nih.gov/21896868
Publikováno v:
Investigative Opthalmology & Visual Science. 55:2452
Purpose Functional studies have detected deficits in retinal signaling in asymptomatic children from families with inherited autosomal dominant retinitis pigmentosa (RP). Whether retinal abnormalities are present earlier during gestation or shortly a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae18b7a651a9608f0a3fd6ba9d0e4732
https://doi.org/10.1167/iovs.13-13723
https://doi.org/10.1167/iovs.13-13723
Autor:
Eric V. Vukmanic, Sang Joon Lee, Henry J. Kaplan, Douglas Emery, Juan P. Fernandez de Castro, Wei Wang, Liang Zhou, Douglas C. Dean, Yongqing Liu
Publikováno v:
Investigative Opthalmology & Visual Science. 55:301
We followed cone and rod development in the pig and we correlated development with the potential for cone and rod precursor integration and differentiation following subretinal transplantation.Rod and cone precursors were identified during developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915ac44cf339debce13a93ab66c4ad71
https://doi.org/10.1167/iovs.13-12600
https://doi.org/10.1167/iovs.13-12600
Autor:
Shigeo Tamiya, Henry J. Kaplan, LanHsin Liu, Kevin McDonald, Juan P. Fernandez de Castro, Kazuhiko Umazume, Patrick A. Scott
Publikováno v:
Investigative Opthalmology & Visual Science. 54:1150
PURPOSE. We tested the efficacy of dasatinib, a Food and Drug Administration (FDA)-approved tyrosine kinase inhibitor, to prevent proliferative vitreoretinopathy (PVR). METHODS. The effect of dasatinib on RPE sheet growth was determined by measuring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c826add85fbab21f9996545dcda2f33e
https://doi.org/10.1167/iovs.12-10418
https://doi.org/10.1167/iovs.12-10418