Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Juan P. Couso"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Translation of 100 to 300 micropeptides from small ORFs within lncRNA was detected by Ribosomal Profiling in Drosophila embryos. These translated small ORFs showed natural selection conserving micropeptide sequence and function.
Externí odkaz:
https://doaj.org/article/5a40e3f904794cdcad53ae9b2f86edeb
Autor:
Emile G. Magny, Ana Isabel Platero, Sarah A. Bishop, Jose I. Pueyo, Daniel Aguilar-Hidalgo, Juan Pablo Couso
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Short open reading frames (smORFs) of less than 100 codons exist in the thousands in metazoan genomes, mostly with yet unknown functions. Here the authors show how a smORF conserved from flies to vertebrates produces a secreted peptide that enhances
Externí odkaz:
https://doaj.org/article/7f17f13f747943899fbf04ba7e53500e
Autor:
Pedro Patraquim, Muhammad Ali Shahzad Mumtaz, José Ignacio Pueyo, Julie Louise Aspden, Juan-Pablo Couso
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-26 (2020)
Abstract Background Ribosomal profiling has revealed the translation of thousands of sequences outside annotated protein-coding genes, including small open reading frames of less than 100 codons, and the translational regulation of many genes. Here w
Externí odkaz:
https://doaj.org/article/4e9cdfd9db1a49e39c612e4d5de59c68
Autor:
Sebastian Kittelmann, Alexandra D Buffry, Franziska A Franke, Isabel Almudi, Marianne Yoth, Gonzalo Sabaris, Juan Pablo Couso, Maria D S Nunes, Nicolás Frankel, José Luis Gómez-Skarmeta, Jose Pueyo-Marques, Saad Arif, Alistair P McGregor
Publikováno v:
PLoS Genetics, Vol 14, Iss 5, p e1007375 (2018)
Convergent phenotypic evolution is often caused by recurrent changes at particular nodes in the underlying gene regulatory networks (GRNs). The genes at such evolutionary 'hotspots' are thought to maximally affect the phenotype with minimal pleiotrop
Externí odkaz:
https://doaj.org/article/1d2d9b4398814abc9a4ff215c13fb8f9
Autor:
Mouli Chakraborty, Estela Selma-Soriano, Emile Magny, Juan Pablo Couso, Manuel Pérez-Alonso, Nicolas Charlet-Berguerand, Ruben Artero, Beatriz Llamusi
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 12, Pp 1569-1578 (2015)
Up to 80% of individuals with myotonic dystrophy type 1 (DM1) will develop cardiac abnormalities at some point during the progression of their disease, the most common of which is heart blockage of varying degrees. Such blockage is characterized by c
Externí odkaz:
https://doaj.org/article/2fb806979e5b4416b927f1c2c3017756
Publikováno v:
Biology Open, Vol 2, Iss 12, Pp 1412-1420 (2013)
Summary Drosophila hemocytes compose the cellular arm of the fly's innate immune system. Plasmatocytes, putative homologues to mammalian macrophages, represent ∼95% of the migratory hemocyte population in circulation and are responsible for the pha
Externí odkaz:
https://doaj.org/article/3808c0896c3e45b199e6221ad8858238
Autor:
José I Pueyo, Emile G Magny, Christopher J Sampson, Unum Amin, Iwan R Evans, Sarah A Bishop, Juan P Couso
Publikováno v:
PLoS Biology, Vol 14, Iss 3, p e1002395 (2016)
Translation of hundreds of small ORFs (smORFs) of less than 100 amino acids has recently been revealed in vertebrates and Drosophila. Some of these peptides have essential and conserved cellular functions. In Drosophila, we have predicted a particula
Externí odkaz:
https://doaj.org/article/8f8e305b64d54c66965a1343bd052418
Publikováno v:
Biology Open, Vol 2, Iss 2, Pp 227-237 (2012)
Summary Sequential addition of segments in the posteriorly growing end of the embryo is a developmental mechanism common to many bilaterians. However, posterior growth and patterning in most animals also entails the establishment of a ‘posterior or
Externí odkaz:
https://doaj.org/article/15ecf97dec3646ab9e1e165253458711
Autor:
Julie L Aspden, Ying Chen Eyre-Walker, Rose J Phillips, Unum Amin, Muhammad Ali S Mumtaz, Michele Brocard, Juan-Pablo Couso
Publikováno v:
eLife, Vol 3 (2014)
Thousands of small Open Reading Frames (smORFs) with the potential to encode small peptides of fewer than 100 amino acids exist in our genomes. However, the number of smORFs actually translated, and their molecular and functional roles are still uncl
Externí odkaz:
https://doaj.org/article/8a6624102f9d459e8aa21603ccaf979b
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15382 (2010)
The Aryl hydrocarbon receptor (Ahr) is the nuclear receptor mediating the toxicity of dioxins--widespread and persistent pollutants whose toxic effects include tumor promotion, teratogenesis, wasting syndrome and chloracne. Elimination of Ahr in mice
Externí odkaz:
https://doaj.org/article/e273f8eec78a4b109df2f9462a0e0139