Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Juan P Couso"'
Autor:
José I Pueyo, Emile G Magny, Christopher J Sampson, Unum Amin, Iwan R Evans, Sarah A Bishop, Juan P Couso
Publikováno v:
PLoS Biology, Vol 14, Iss 3, p e1002395 (2016)
Translation of hundreds of small ORFs (smORFs) of less than 100 amino acids has recently been revealed in vertebrates and Drosophila. Some of these peptides have essential and conserved cellular functions. In Drosophila, we have predicted a particula
Externí odkaz:
https://doaj.org/article/8f8e305b64d54c66965a1343bd052418
Autor:
Pedro Patraquim, Muhammad Ali Shahzad Mumtaz, José Ignacio Pueyo, Julie Louise Aspden, Juan-Pablo Couso
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-26 (2020)
Abstract Background Ribosomal profiling has revealed the translation of thousands of sequences outside annotated protein-coding genes, including small open reading frames of less than 100 codons, and the translational regulation of many genes. Here w
Externí odkaz:
https://doaj.org/article/4e9cdfd9db1a49e39c612e4d5de59c68
Autor:
Sebastian Kittelmann, Alexandra D Buffry, Franziska A Franke, Isabel Almudi, Marianne Yoth, Gonzalo Sabaris, Juan Pablo Couso, Maria D S Nunes, Nicolás Frankel, José Luis Gómez-Skarmeta, Jose Pueyo-Marques, Saad Arif, Alistair P McGregor
Publikováno v:
PLoS Genetics, Vol 14, Iss 5, p e1007375 (2018)
Convergent phenotypic evolution is often caused by recurrent changes at particular nodes in the underlying gene regulatory networks (GRNs). The genes at such evolutionary 'hotspots' are thought to maximally affect the phenotype with minimal pleiotrop
Externí odkaz:
https://doaj.org/article/1d2d9b4398814abc9a4ff215c13fb8f9
Autor:
Mouli Chakraborty, Estela Selma-Soriano, Emile Magny, Juan Pablo Couso, Manuel Pérez-Alonso, Nicolas Charlet-Berguerand, Ruben Artero, Beatriz Llamusi
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 12, Pp 1569-1578 (2015)
Up to 80% of individuals with myotonic dystrophy type 1 (DM1) will develop cardiac abnormalities at some point during the progression of their disease, the most common of which is heart blockage of varying degrees. Such blockage is characterized by c
Externí odkaz:
https://doaj.org/article/2fb806979e5b4416b927f1c2c3017756
Autor:
Julie L Aspden, Ying Chen Eyre-Walker, Rose J Phillips, Unum Amin, Muhammad Ali S Mumtaz, Michele Brocard, Juan-Pablo Couso
Publikováno v:
eLife, Vol 3 (2014)
Thousands of small Open Reading Frames (smORFs) with the potential to encode small peptides of fewer than 100 amino acids exist in our genomes. However, the number of smORFs actually translated, and their molecular and functional roles are still uncl
Externí odkaz:
https://doaj.org/article/8a6624102f9d459e8aa21603ccaf979b
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e15382 (2010)
The Aryl hydrocarbon receptor (Ahr) is the nuclear receptor mediating the toxicity of dioxins--widespread and persistent pollutants whose toxic effects include tumor promotion, teratogenesis, wasting syndrome and chloracne. Elimination of Ahr in mice
Externí odkaz:
https://doaj.org/article/e273f8eec78a4b109df2f9462a0e0139
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Next generation sequencing (NGS) has enabled an in-depth look into genes, transcripts and their translation at the genomic scale. The application of NGS sequencing of ribosome footprints (Ribo-Seq) reveals translation with single nucleotide (nt) reso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84da68601869b450d02db2f48e6bed5d
https://doi.org/10.1042/bst20150170
https://doi.org/10.1042/bst20150170
Publikováno v:
Evolution & Development. 10:705-716
Although the expression of the POU homeodomain gene nubbin (nub) has been examined in several arthropod species, its function has been studied only in Drosophila. Here, we provide the first insight into functional roles of this gene in a hemimetabolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ebd1863dc60cefeb580f96454da19db
https://doi.org/10.1111/j.1525-142x.2008.00284.x
https://doi.org/10.1111/j.1525-142x.2008.00284.x
Publikováno v:
Development. 129:1273-1281
The Drosophila rotund gene is required in the wings, antenna, haltere, proboscis and legs. A member of the Rac family of GTPases, denoted the rotund racGAP gene, was previously identified in the rotund region. However, previous studies indicated that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca3aef7d1a5ec8edb0880aaa8ea66d8
https://doi.org/10.1242/dev.129.5.1273
https://doi.org/10.1242/dev.129.5.1273
Autor:
Ying Chen Eyre-Walker, Julie L Aspden, Michele Brocard, Juan P. Couso, Unum Amin, Rose J Phillips
Thousands of small Open Reading Frames (smORFs) encoding small peptides of fewer than 100 amino acids exist in our genomes. Examples of functional smORFs have been characterised in a few species but the actual number of translated smORFs, and their m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::798c95917bcfff6a151a099c024d35d8
https://doi.org/10.1101/002998
https://doi.org/10.1101/002998
