Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Juan Mena-Segovia"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
IntroductionThe pedunculopontine nucleus (PPN) plays a role in coordinating complex behaviors and adapting to changing environmental conditions. The specific role of cholinergic neurons in PPN function is not well understood, but their ascending conn
Externí odkaz:
https://doaj.org/article/792051e5110a474690d72ab9ba5c5779
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The cholinergic midbrain is involved in a wide range of motor and cognitive processes. Cholinergic neurons of the pedunculopontine (PPN) and laterodorsal tegmental nucleus (LDT) send long-ranging axonal projections that target sensorimotor a
Externí odkaz:
https://doaj.org/article/8fdc10ed3f17456bb3679e14ce569b00
Autor:
Daniel Dautan, Icnelia Huerta-Ocampo, Nadine K. Gut, Miguel Valencia, Krishnakanth Kondabolu, Yuwoong Kim, Todor V. Gerdjikov, Juan Mena-Segovia
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Acetylcholine (ACh) in the striatum is involved in mediating action flexibility. Here the authors show that midbrain cholinergic nuclei provide a new source of Ach in the striatum, form excitatory synapses with striatal cholinergic interneurons (CIN)
Externí odkaz:
https://doaj.org/article/d9ef9606aeda407eb4073590fbf4e724
Autor:
Daniel Dautan, Adrienn Kovács, Tsogbadrakh Bayasgalan, Miguel A. Diaz-Acevedo, Balazs Pal, Juan Mena-Segovia
Publikováno v:
Cell Reports, Vol 36, Iss 8, Pp 109594- (2021)
Summary: The mesencephalic locomotor region (MLR) serves as an interface between higher-order motor systems and lower motor neurons. The excitatory module of the MLR is composed of the pedunculopontine nucleus (PPN) and the cuneiform nucleus (CnF), a
Externí odkaz:
https://doaj.org/article/ebafdd0812d0450e8052327325c040dc
Autor:
Nadine K. Gut, Juan Mena-Segovia
Publikováno v:
Neurobiology of Disease, Vol 128, Iss , Pp 59-66 (2019)
Cholinergic neurons of the pedunculopontine nucleus (PPN) are interconnected with all the basal ganglia structures, as well as with motor centers in the brainstem and medulla. Recent theories put into question whether PPN cholinergic neurons form par
Externí odkaz:
https://doaj.org/article/c2b0953e07454a5da4ba188ece948792
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e67540 (2013)
Slow oscillations are a hallmark of slow wave sleep. They provide a temporal framework for a variety of phasic events to occur and interact during sleep, including the expression of high-frequency oscillations and the discharge of neurons across the
Externí odkaz:
https://doaj.org/article/e3388cec57b344619b05c877f3f6750c
Dopamine enables purposive behavior and adjusts vigor as a function of the relative value of actions. In Parkinson’s disease, dopamine neurons die and give rise to a series of motor and cognitive changes that interfere with the expression of voliti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::148841e4f7561f00c7bf4d45758a4bab
https://doi.org/10.1101/2022.01.18.476772
https://doi.org/10.1101/2022.01.18.476772
Autor:
Nadine K. Gut, Juan Mena-Segovia
Publikováno v:
Trends Neurosci
Cognitive flexibility enables effective switching between mental processes to generate appropriate responses. Cholinergic neurons (CNs) within the pedunculopontine nucleus (PPN) are associated with many functions, but their contribution to cognitive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de02d79558ebd44652861c857993fe8
https://doi.org/10.1016/j.tins.2022.04.005
https://doi.org/10.1016/j.tins.2022.04.005
Autor:
Juan Mena-Segovia, Nadine K. Gut
Publikováno v:
Neurobiol Dis
Neurobiology of Disease, Vol 128, Iss, Pp 59-66 (2019)
Neurobiology of Disease, Vol 128, Iss, Pp 59-66 (2019)
Cholinergic neurons of the pedunculopontine nucleus (PPN) are interconnected with all the basal ganglia structures, as well as with motor centers in the brainstem and medulla. Recent theories put into question whether PPN cholinergic neurons form par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11da8367c0f3d72ea42614ca81a097b
https://doi.org/10.1016/j.nbd.2018.09.008
https://doi.org/10.1016/j.nbd.2018.09.008
Publikováno v:
The Journal of Neuroscience. 39:4727-4737
The main excitatory inputs to the striatum arising from the cortex and the thalamus innervate both striatal spiny projection neurons and interneurons. These glutamatergic inputs to striatal GABAergic interneurons have been suggested to regulate the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a084bb0d4cfa3720cdb0b9e346ef962
https://doi.org/10.1523/jneurosci.2913-18.2019
https://doi.org/10.1523/jneurosci.2913-18.2019