Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Juan Marugan"'
Autor:
Ron Benyair, Sai Srinivas Panapakkam Giridharan, Pilar Rivero-Ríos, Junya Hasegawa, Emily Bristow, Eeva-Liisa Eskelinen, Merav D Shmueli, Vered Fishbain-Yoskovitz, Yifat Merbl, Lisa M Sharkey, Henry L. Paulson, Phyllis I Hanson, Samarjit Patnaik, Ismael Al-Ramahi, Juan Botas, Juan Marugan, Lois S. Weisman
Publikováno v:
Autophagy Reports, Vol 2, Iss 1 (2023)
Many neurodegenerative diseases, including Huntington’s disease (HD) and Alzheimer’s disease (AD), occur due to an accumulation of aggregation-prone proteins, which results in neuronal death. Studies in animal and cell models show that reducing t
Externí odkaz:
https://doaj.org/article/025cf5e3def14b5b85e8e1ea105c7f8c
Autor:
Samar Sayedyahossein, Jessica Smith, Elena Barnaeva, Zhigang Li, Jun Choe, Michael Ronzetti, Christopher Dextras, Xin Hu, Juan Marugan, Noel Southall, Bolormaa Baljinnyam, Louise Thines, Andy D. Tran, Marc Ferrer, David B. Sacks
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract The small GTPase Cdc42 is an integral component of the cytoskeleton, and its dysregulation leads to pathophysiological conditions, such as cancer. Binding of Cdc42 to the scaffold protein IQGAP1 stabilizes Cdc42 in its active form. The inter
Externí odkaz:
https://doaj.org/article/1a21390492ac417fa1c9c755b05598aa
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-13 (2021)
Abstract Background Repetitive mild traumatic brain injury (mTBI) can result in chronic visual dysfunction. G-protein receptor 110 (GPR110, ADGRF1) is the target receptor of N-docosahexaenoylethanolamine (synaptamide) mediating the anti-neuroinflamma
Externí odkaz:
https://doaj.org/article/18e3ce6773844654a15a2b3071f2fe61
Autor:
Anju Singh, Myagmarjav Dashynam, Bryan Chim, Thelma M. Escobar, Xiuhuai Liu, Xin Hu, Samarjit Patnaik, Xin Xu, Noel Southall, Juan Marugan, Ajit Jadhav, Vanja Lazarevic, Stefan A. Muljo, Marc Ferrer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract MicroRNA miR-155 is an important regulatory molecule in the immune system and is highly expressed and functional in Th17 cells, a subset of CD4+ T helper cells which are key players in autoimmune diseases. Small molecules that can modulate m
Externí odkaz:
https://doaj.org/article/28cf79f1b82146509af8f9f2b2558447
Autor:
Houda G. Khaled, Hongxuan Feng, Xin Hu, Xin Sun, Wang Zheng, Pan P. Li, Dobrila D. Rudnicki, Wenjuan Ye, Yu-Chi Chen, Noel Southall, Juan Marugan, Christopher A. Ross, Marc Ferrer, Mark J. Henderson, Russell L. Margolis
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in exon 1 of huntingtin (HTT). While there are currently no disease-modifying treatments for HD, recent efforts have focused on the development of n
Externí odkaz:
https://doaj.org/article/e1dbdd8b7e1f49f1934d1a2643d9a73c
Autor:
Heung-Sun Kwon, Karl Kevala, Haohua Qian, Mones Abu-Asab, Samarjit Patnaik, Juan Marugan, Hee-Yong Kim
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5340 (2023)
It is extremely difficult to achieve functional recovery after axonal injury in the adult central nervous system. The activation of G-protein coupled receptor 110 (GPR110, ADGRF1) has been shown to stimulate neurite extension in developing neurons an
Externí odkaz:
https://doaj.org/article/2c41d3789de046fbb0bddb5918d9f0e4
Autor:
Nivedita Sengupta, Marko Jović, Elena Barnaeva, David W. Kim, Xin Hu, Noel Southall, Milan Dejmek, Ivana Mejdrova, Radim Nencka, Adriana Baumlova, Dominika Chalupska, Evzen Boura, Marc Ferrer, Juan Marugan, Tamas Balla
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 3, Pp 683-693 (2019)
The minor phospholipid, phosphatidylinositol 4-phosphate (PI4P), is emerging as a key regulator of lipid transfer in ER-membrane contact sites. Four different phosphatidylinositol 4-kinase (PI4K) enzymes generate PI4P in different membrane compartmen
Externí odkaz:
https://doaj.org/article/140be2b4c8d44d3c8e02d4ac3aa65593
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3386 (2021)
Recovery from axonal injury is extremely difficult, especially for adult neurons. Here, we demonstrate that the activation of G-protein coupled receptor 110 (GPR110, ADGRF1) is a mechanism to stimulate axon growth after injury. N-docosahexaenoylethan
Externí odkaz:
https://doaj.org/article/e92dfe570c5d4f1daead086292b08c39
Autor:
Ji-Won Lee, Bill X. Huang, HeungSun Kwon, Md Abdur Rashid, Giorgi Kharebava, Abhishek Desai, Samarjit Patnaik, Juan Marugan, Hee-Yong Kim
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
N-docosahexaenoylethanolamine (synaptamide) promotes neurogenesis but the molecular mechanism involved is unknown. Here, the authors show that orphan G-protein coupled receptor 110 is the synaptamide receptor, with deletion in mice affecting developm
Externí odkaz:
https://doaj.org/article/eda1618c0c6741bbac8ea7b6da510a61
Autor:
Xiaoli Zhang, Xiping Cheng, Lu Yu, Junsheng Yang, Raul Calvo, Samarjit Patnaik, Xin Hu, Qiong Gao, Meimei Yang, Maria Lawas, Markus Delling, Juan Marugan, Marc Ferrer, Haoxing Xu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Reactive oxygen species (ROS) damage cell components, necessitating their clearance through autophagy. Here, the authors show that ROS can induce autophagy by triggering TRPML1 to release Ca2+from the lysosomal lumen, in turn activating the autophagy
Externí odkaz:
https://doaj.org/article/5ea7884007644b998455beef98724838