Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Juan Martínez-Oliván"'
Autor:
David Luna-Cerralbo, Irene Blasco-Machín, Susana Adame-Pérez, Verónica Lampaya, Ana Larraga, Teresa Alejo, Juan Martínez-Oliván, Esther Broset, Pierpaolo Bruscolini
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3050-3064 (2024)
The concept of “codon optimisation” involves adjusting the coding sequence of a target protein to account for the inherent codon preferences of a host species and maximise protein expression in that species. However, there is still a lack of cons
Externí odkaz:
https://doaj.org/article/aac216204ea849e7a516a78851084c03
Autor:
Teresa Alejo, Alfonso Toro-Córdova, Laura Fernández, Andrea Rivero, Andrei Mihai Stoian, Luna Pérez, Victor Navarro, Juan Martínez-Oliván, Diego de Miguel
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10603 (2024)
The success of mRNA vaccines against SARS-CoV-2 has prompted interest in mRNA-based pharmaceuticals due to their rapid production, adaptability, and safety. Despite these advantages, the inherent instability of mRNA and its rapid degradation in vivo
Externí odkaz:
https://doaj.org/article/d0dcf3b086b842bd86593f24a3e8073a
Intradomain Confinement of Disulfides in the Folding of Two Consecutive Modules of the LDL Receptor.
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132141 (2015)
The LDL receptor internalizes circulating LDL and VLDL particles for degradation. Its extracellular binding domain contains ten (seven LA and three EGF) cysteine-rich modules, each bearing three disulfide bonds. Despite the enormous number of disulfi
Externí odkaz:
https://doaj.org/article/eef2f2bb5a974165b711c7c984b8366e
Autor:
Juan Martínez-Oliván, Adrián Velázquez-Campoy, Rubén Laplaza, Patricia Ferreira, Raquel Villanueva, Milagros Medina, Javier Sancho, Silvia Romero-Tamayo
Publikováno v:
Antioxidants & Redox Signaling. 30
Aims: The human apoptosis-inducing factor (hAIF) supports OXPHOS biogenesis and programmed cell death, with missense mutations producing neurodegenerative phenotypes. hAIF senses the redox...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a285ea9bf773dbbd2bf77a2be13f803
https://doi.org/10.1089/ars.2018.7658
https://doi.org/10.1089/ars.2018.7658
Autor:
Juan Martínez-Oliván, Vladimir Espinosa Angarica, Zurine Rozado-Aguirre, Adrián Velázquez-Campoy, Javier Sancho, Xabier Arias-Moreno
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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The low-density lipoprotein receptor (LDLR) captures circulating lipoproteins and delivers them in the endosome for degradation. Its function is essential for cholesterol homeostasis, and mutations in the LDLR are the major cause of familiar hypercho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1402dde8aebc12cb39c543f7aef524aa
https://doi.org/10.1111/febs.12811
https://doi.org/10.1111/febs.12811
Autor:
Ramon Hurtado-Guerrero, Alberto Marina, Javier Sancho, Xabier Arias-Moreno, Juan Martínez-Oliván, Laura Miguel-Romero, Pierpaolo Bruscolini, José Alberto Carrodeguas
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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The LDL receptor (LDLR) internalizes LDL and VLDL particles. In the endosomes, it adopts a closed conformation important for recycling, by interaction of two modules of the ligand binding domain (LR4-5) and a β-propeller motif. Here, we investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e8ed73891f5abd2b633c3ab5478a50
http://hdl.handle.net/10261/141988
http://hdl.handle.net/10261/141988
Autor:
Juan Martínez-Oliván, Xabier Arias-Moreno, Oscar Millet, Adrián Velázquez-Campoy, Javier Sancho
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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The molecular mechanism of lipoprotein binding by the low-density lipoprotein (LDL) receptor (LDLR) is poorly understood, one reason being that structures of lipoprotein-receptor complexes are not available. LDLR uses calcium-binding repeats (LRs) to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f923812e625f293458a137ed0f2407d2
https://pubmed.ncbi.nlm.nih.gov/24447298
https://pubmed.ncbi.nlm.nih.gov/24447298