Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Juan Mangas Sanchez"'
Publikováno v:
Angewandte Chemie International Edition. 61
The combination of small-molecule catalysis and enzyme catalysis represents an underexploited area of research with huge potential in asymmetric synthetic chemistry due to both compatibility of reaction conditions and complementary reactivity. Herein
Publikováno v:
Methodologies in Amine Synthesis
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Zaguán. Repositorio Digital de la Universidad de Zaragoza
Organic chemistry provides society with fundamental products we use daily. Concerns about the impact that the chemical industry has over the environment is propelling major changes in the way we manufacture chemicals. Biocatalysis offers an alternati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53a37288cf68890d585a39e7d4db477
http://hdl.handle.net/10261/272073
http://hdl.handle.net/10261/272073
Publikováno v:
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
instname
Inspired by nature, synthetic chemists try to mimic the efficient metabolic networks in living organisms to build complex molecules by combining different types of catalysts in the same reaction vessel. These multistep cascade processes provide many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a38f7d52ede7be12ef43247efd3262
http://zaguan.unizar.es/record/118273
http://zaguan.unizar.es/record/118273
Autor:
Jouni Ruupunen, Mehmet Mervan Çakar, Barış Binay, Nicholas J. Turner, Jarkko Valjakka, Juan Mangas-Sanchez, Deniz Yildirim, William R. Birmingham, Ossi Turunen
Publikováno v:
Biotechnology Letters. 42:2251-2262
Formate dehydrogenases (FDHs) are NAD(P)H-dependent enzymes that catalyse the reversible oxidation of formate to CO2. The main goal was to use directed evolution to obtain variants of the FDH from Chaetomium thermophilum (CtFDH) with enhanced reducti
Autor:
Jeremy I. Ramsden, Juan Mangas-Sanchez, Sarah L. Montgomery, Sasha R. Derrington, Rachel S. Heath, Nicholas J. Turner, Keith R. Mulholland
Publikováno v:
Journal of the American Chemical Society
Ramsden, J I, Heath, R S, Derrington, S R, Montgomery, S L, Mangas-Sanchez, J, Mulholland, K R & Turner, N J 2019, ' Biocatalytic N-Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades ', Journal of the American Chemical Society . https://doi.org/10.1021/jacs.8b11561
Ramsden, J I, Heath, R S, Derrington, S R, Montgomery, S L, Mangas-Sanchez, J, Mulholland, K R & Turner, N J 2019, ' Biocatalytic N-Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades ', Journal of the American Chemical Society . https://doi.org/10.1021/jacs.8b11561
The alkylation of amines with either alcohols or carboxylic acids represents a mild and safe alternative to the use of genotoxic alkyl halides and sulfonate esters. Here we report two complementary one-pot systems in which the reductive aminase (RedA
Application of engineered biocatalysts for the synthesis of active pharmaceutical ingredients (APIs)
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Protein Engineering
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Protein Engineering
Genetic engineering of enzymes has played a significant role in multiple pharmaceutical synthetic processes. The need for selective, robust catalysts that can operate under process chemistry conditions has driven the need for mutagenesis approaches,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f0aaf0a8b217077a206f786b9e890c
http://hdl.handle.net/10261/270557
http://hdl.handle.net/10261/270557
Publikováno v:
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Tetrahedron
Turner, N, Marshall, J & Mangas-Sanchez, J 2021, ' Expanding the synthetic scope of biocatalysis by enzyme discovery and protein engineering ', Tetrahedron, vol. 82, 131926 . https://doi.org/10.1016/j.tet.2021.131926
Digital.CSIC. Repositorio Institucional del CSIC
instname
Tetrahedron
Turner, N, Marshall, J & Mangas-Sanchez, J 2021, ' Expanding the synthetic scope of biocatalysis by enzyme discovery and protein engineering ', Tetrahedron, vol. 82, 131926 . https://doi.org/10.1016/j.tet.2021.131926
Digital.CSIC. Repositorio Institucional del CSIC
This paper is dedicated to the memory of Jon Williams who was a pioneer of chemo-enzymatic catalysis, a field which has grown significantly thanks to his vision and ideas.
Despite the growing impact of enzyme catalysis in industrial chemistry, t
Despite the growing impact of enzyme catalysis in industrial chemistry, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed45b1a3a4db4813586eaae92e188a0
http://zaguan.unizar.es/record/109457
http://zaguan.unizar.es/record/109457
Autor:
Gideon Grogan, Thomas W. Thorpe, Nicholas J. Turner, Ryan B. Palmer, Jeremy I. Ramsden, Sebastian C. Cosgrove, Juan Mangas-Sanchez, James R. Marshall, Mahima Sharma
Publikováno v:
Chemical Science
Mangas-Sanchez, J, Sharma, M, Cosgrove, S C, Ramsden, J I, Marshall, J R, Thorpe, T W, Palmer, R B, Grogan, G & Turner, N J 2020, ' Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases ', Chemical Science, vol. 11 . https://doi.org/10.1039/D0SC02253E
Mangas-Sanchez, J, Sharma, M, Cosgrove, S C, Ramsden, J I, Marshall, J R, Thorpe, T W, Palmer, R B, Grogan, G & Turner, N J 2020, ' Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases ', Chemical Science, vol. 11 . https://doi.org/10.1039/D0SC02253E
Chiral primary amines are important intermediates in the synthesis of pharmaceutical compounds. Fungal reductive aminases (RedAms) are NADPH-dependent dehydrogenases that catalyse reductive amination of a range of ketones with short-chain primary ami
Autor:
Jeremy I. Ramsden, David Woodlock, Nicholas J. Turner, Juan Mangas-Sanchez, Rachel S. Heath, Christopher J. Taylor, Ahir Pushpanath, Beatriz Dominguez, Sarah L. Montgomery, Serena Bisagni, James L. Galman, James R. Marshall, Ulrike Klemstein
Publikováno v:
Science Advances
Turner, N, Montgomery, S, Pushpanath, A, Heath, R, Marshall, J, Klemstein, U, Galman, J, Woodlock, D, Bisagni, S, Taylor, C, Mangas-Sanchez, J, Ramsden, J & Dominguez, B 2020, ' Characterization of imine reductases in reductive amination for the exploration of structure-activity relationships ', Science Advances, vol. 6, no. 21, pp. eaay9320 . https://doi.org/10.1126/sciadv.aay9320
Turner, N, Montgomery, S, Pushpanath, A, Heath, R, Marshall, J, Klemstein, U, Galman, J, Woodlock, D, Bisagni, S, Taylor, C, Mangas-Sanchez, J, Ramsden, J & Dominguez, B 2020, ' Characterization of imine reductases in reductive amination for the exploration of structure-activity relationships ', Science Advances, vol. 6, no. 21, pp. eaay9320 . https://doi.org/10.1126/sciadv.aay9320
Sequence function relationships help to understand how imine reductase enzymes perform reductive amination in water.
Imine reductases (IREDs) have shown great potential as catalysts for the asymmetric synthesis of industrially relevant chiral am
Imine reductases (IREDs) have shown great potential as catalysts for the asymmetric synthesis of industrially relevant chiral am